We developed a new method for replicating psychedelic tracer effects in detail: the Tracer Replication Tool. This tool gives us a window into how the time-like texture of experience determines the state of consciousness we find ourselves in, which clarifies what makes both meditating and taking psychedelics such powerful state-switching activities. We discuss how the technique of using the tracer tool may find useful applications, such as allowing us to describe exotic “ineffable” experiences in clear language, standardize a scale of intensity of psychedelic drug effects (a.k.a. a “High-O-Meter”), help us quantify the synergy between different drugs, and test theories for what makes an experience feel good or bad such as the Symmetry Theory of Valence. The pilot data collected with this tool so far is suggestive of the following patterns: (1) THC and HPPD result in a smooth and faint trail effect. (2) The characteristic frequencies of the strobe and replay effects for 2C-B are slower than those of either DMT or 5-MeO-DMT. And, (3) whereas DMT comes with a strong color pulsing effect leading to very colorful visuals, 5-MeO-DMT gives rise to monochromatic tracer effects. We conclude by discussing the implications of these patterns in light of an analysis of experience that allows for a varying time-like texture. We hope to inspire the scientific community and curious psychonauts to use this tool to help us uncover more patterns.
Rhythmic activity in the brain is a staple of neuroscience. It shows up in spiking neurons, synchronous oscillations at the level of networks, global patterns of resonance and coherence in EEG recordings, and in many other places. The book Rhythms of the Brain by György Buzsáki is a systematic review of what was known about these rhythms back in 2006. One of the things György talks about in this book is how a lot of neuroscience techniques focused on finding the neural correlates of perception tend to consider the variable activation of neurons from one trial to the next as noise. In experiments that look into how neurons respond to a specific stimulus, datasets are constructed that track the neuronal activity that stays the same across trials. That which changes is discarded as noise, and György argues that such “noise” is really where the information about the internal rhythms is to be found. We concur with the assessment that understanding these native rhythms is key for making sense of how the brain works. Perhaps one of the most exciting developments in this space is the method of Connectome-Specific Harmonic Wave analysis (Atasoy et al., 2016). This way of analyzing fMRI data describes a “brain state” as, at least partly, consisting of a weighted sum of its resonant modes. This paradigm has been used with success for comparing brain states across widely different categories of experience: LSD, ketamine, and anesthesia, among others (Luppi et al., 2020).
These are exciting times for exploring the native rhythms of nervous systems in neuroscience. But what about their subjective quality? One would hope that we could connect a formal third-person view of these rhythms with their experiential component. Alas, at this point in time the behavioral and physiological component of brain rhythms is far better understood than the way in which they cash out in subjective qualities.
Could there be a way to make these rhythms easily visible to ourselves as scientists? One interesting lens through which to see psychedelics is in terms of the way they excite specific rhythm-generating networks. This lens would present psychedelic states as giving you a sense of what it feels like to have many of these rhythms simultaneously activated, thus having access to a wider repertoire of brain states (Atasoy et al., 2017).
But you don’t need psychedelics to realize there’s something fishy about the solidity of our perception. Intuitively, one may get the impression that normal everyday states of consciousness do not show the signatures of being the result of ensembles of rhythmic activity. That said, some would affirm that paying attention to the artifacts of our perception may in fact be a window into these rhythms. For example, Lehar’s Harmonic Resonance Theory of the gestalt properties of perception (Lehar, 1999) attempts to explain the characteristics of well known visual illusions (such as the Kanizsa triangle) with principles derived from the superposition of rhythmic activity.
Paying close attention to the act of observing an object over time has led some researchers to play with the idea that our experience of the world is best understood as music (Lloyd, 2013), for our feeling of a solid surrounding results from the interplay between finely coordinated sensations and acts of interpretation. Indeed, the fluidity of sensory impressions betrays our common-sense notion that we experience a solid and stable world. It often takes a perturbation out of our normal everyday state of consciousness to notice this. As an example here, we can point out that insight meditation practices peer into the illusion of solidity and continuity of our experience, whereas concentration meditation enhances these illusions (Ingram, 2018).
Arguably, like a fish who cannot notice water until it’s taken out of it, the stitching process by which our brain constructs reality is usually hidden from view. To be taken out of the water in this context would be to be in a state that allows you to notice the seams of one’s experience. To the extent that this normal stitching process breaks down in exotic states of consciousness, they are clearly useful for research in this domain. Thus we argue that the artifacts of perception in alien states of consciousness are not noise; they provide hints for how normal experience is constructed. In particular, we posit that “psychedelic tracers” (i.e. the cluster of persisting visual phenomena caused by hallucinogens) may be a window into how rhythmic feedback dynamics are used to control the content of our experience. For this reason, we have been interested in turning what until now has been qualitative descriptions and informal approximations of this phenomenon into concrete quantitative replications.
In what follows we will showcase the value of a psychophysics toolkit we developed at the Qualia Research Institute called the Tracer Replication Tool for modeling psychedelic tracer phenomenology. Although we will focus on psychedelic experiences, this tool can have a much broader set of applications. For example, we show how the tool can be used to visualize and quantify the severity of HPPD, which currently has a very qualitative, and imprecise at best, diagnostic criteria. Likewise, the tool has the potential to bring together the complex clinical presentation of visual disturbances such as palinopsia, photopsia, oscillopsia, visual snow, and other conditions, into a coherent framework. Perhaps, speculatively, the connection between all these visual disturbances is to be found in the dysregulation of the rhythms of the visual control systems, which is what the tracer tool sets out to quantify.
The only attempt of arriving at quantitative replications of psychedelic tracers in the scientific literature we are aware of is by (Dubois & VanRullen, 2011). They used multiple-exposure stroboscopic photography in order to depict video scenes. They then asked many people who have had LSD experiences to identify the strobe frequency that best approximated their tracers (which on average was in the 15-20 Hz range).
As we will see, our model for psychedelic tracers is more detailed: it has multiple persistence of vision effects that combine together into a complex tracer. For this reason, the kind of tracers used in Dubois & VanRullen turn out to be a special case of our tool, which we call the strobeeffect:
LSD users perceive a series of discrete positive afterimages in the wake of moving objects, a percept that has been likened to a multiple-exposure stroboscopic photograph, somewhat akin to Etienne-Jules Marey’s chronophotographs  from 1880, or to more recent digital art produced in a few clicks (Figure 1).
Multiple-exposure stroboscopic photograph. (source)
By using a wider set of effects, the Tracer Replication Tool might give us hints about how psychedelics disrupt native rhythms given how they affect the processing of perceptual information at a granular level.
Before we provide the full set of tracer effects along with their associated vocabulary, let us jump into the preliminary psychedelic replications we have obtained thanks to this tool.
Over the years since I’ve run the Qualia Computing blog, I’ve received many messages from people who, for lack of a better term, we could call rational psychonauts. This should not be too surprising, with pieces like “How to Secretly Communicate with People on LSD” and “5-MeO-DMT vs. N,N-DMT: The 9 Lenses”, the site has become a bit of a Schelling point for people who like to blend computational reasoning and the study of exotic states of consciousness. These rational psychonauts are people who not only are well acquainted with exotic states of consciousness, but also like to use a scientific and rational lens to make sense of such states. In particular, people in this cluster often ask me to send them experiments to try out next time they take a psychedelic substance. I certainly never encourage them to take drugs, but under the assumption they will do so anyway, I sometimes send them tasks to do. Thus, once we had a prototype for the tracer tool, I already had a set of more than willing anonymous pilot participants. I sent them the link to the tool along with some brief instructions. Namely:
Look at the ball for a few minutes in state X (where X can be any substance, meditation, etc.). Then as soon as you come down, try to fiddle with the parameters on the left until the simulated tracer looks as close as possible to how you experienced it in the state. When you are ready, simply click “submit parameters” and add info about what the state you were in was at the time. In the case of HPPD, just try your best to replicate the tracer (I know it gets confusing when we talk about the tracers of the simulated tracers, but try to ignore those and just replicate the tracer of the original input).
Mild HPPD (participant said it was strongest on color red)
12.5mg edible, 60 minutes post-ingestion
15mg edible, 90 minutes post-ingestion
20mg orally ingested
Notice how although the replication of the higher dosage is more mild in a way, they both share the presence of a strobe effect at roughly 5.5 Hz!
The higher dose has a complex mixture of effects, including 40 Hz color pulsing (positive and negative afterimages mixed together), 22 Hz replay, and 27 Hz strobe. I’ll note that the participant included the following comment: “Aside from extremely fast tracers, the white space consisted of pixelated fractals. Color was abundant.”
As we will discuss further below, it is worth noting that at least in this sample, there are no color pulsing effects present (which is unlike “regular” DMT).
Drug Combination: Mescaline + ETH-LAD
125μg ETH-LAD + 2 teaspoons of San Pedro powder
The above is the only datapoint we have so far from the combination of psychoactive substances. The participant took 125μg of ETH-LAD, and then two and a half hours later 2 teaspoons of San Pedro powder. The replication is of the way the ball looked like 5 hours after taking the first drug.
Let us now look into the specifics of the tracer tool:
Core effects are pillars of the tracer tool where a particular feedback dynamic is used. The core effects include trails, strobe, and replay.
A modifier effect is one that plays with a core effect and alters it in some way. We will talk along the way about the modifying effects of persistence, intensity, and frequency, and then have a separate section to talk in more detail about the modifier effects of envelope (ADSR), pulse, and color pulse.
Trails (Core Effect)
This is perhaps the most basic effect. Making an analogy with sound, trails are akin to a soft reverb with no delay:
The three settings for trails are: persistence, intensity, and exponential decay (which is binary in the current implementation and otherwise takes on the value of linear decay). Persistence determines how quickly the tracer vanishes, whereas intensity is a constant multiplier for the entire trail. Thus, by changing those parameters you can choose between e.g. a long but dim trail or a short but bright trail.
The exponential decay parameter slightly changes how quickly the brightness goes down; when it’s on, the trails go down more smoothly (cf. gamma correction).
Strobe (Core Effect)
The strobe effect takes snapshots of the input at regular intervals. It works like chronophotography, and it is perhaps what most people think about when you first talk about visual tracers. It is the effect that Dubois & VanRullen used to find that LSD produces visual tracers at ~15-20 Hz.
Strobe effect at 16.4 Hz
The strobe effect, just as the traileffect, also has intensity, persistence, and exponential decay modifiers. In addition, it also has frequency, which encodes how many snapshots per second are being taken.
Note: The current implementation of the trails feature is done with a very fast strobe. In this way, when you set the strobe frequency to the maximum you get something that starts to look a little like the trails effect.
Replay (Core Effect)
With an analogy to sound, replay would be akin to adding an echo or delay to a signal. Replay adds to the raw signal a copy of the output from a fraction of a second into the past. The result is a current output that contains a sequence of increasingly dimmer video replays of itself at regular time intervals into the past.
6 Hz Replay
As with strobe, replay has intensity, persistence, exponential decay, and frequency as its modifying effects.
Note: the replay effect is difficult to distinguish from the strobe effect with only still images
This is a modifier effect that can apply to trails, strobes, and replays (right now the implementation only applies to strobe, but we may change that in the future). It takes a fraction of the input and modulates it with a sine wave at a given frequency. This way the trails, strobes, and replays can come and go (either in part or in full) at a given frequency. This adds sparkle to the experience, and it can plausibly help create a sense of reality or object-permanence for the hallucinations as they “vibrate at their own frequency”.
Compare the difference between a strobe at 4 Hz vs. a strobe at 4 Hz with a pulse at 2 Hz:
4 Hz Strobe
4 Hz Strobe + 2 Hz Pulse at 50% amplitude
As you can see, the pulsing effect makes the strobes look like they have a sort of life of their own.
This modifier effect was something we decided to add because James Kent of Psychedelic Information Theory (Kent, 2010) talks about ADSR envelopes for tracers in the section titled “Control Interruption Model of Psychedelic Action”:
Using control interrupts as the source of hallucinogenesis, we can model hallucinogenic frame distortion of multisensory perception the same way we model sound waves produced by synthesizers; by plotting the attack, decay, sustain, and release (ADSR envelope) of the hallucinogenic interrupt as it effects consciousness. (Fig. 2)3,4 For example, nitrous oxide (N20) inhalation alters consciousness in such a way that all perceptual frames arise and fall with a predictable “wah-wah-wah” time signature. The throbbing “wah-wha-wah” of the N20 experience is a stable standing wave formation that begins when the molecule hits the neural network and ends when it is metabolized, but for the duration of N20 action the “wah-wah-wah” completely penetrates all modes of sensory awareness with a strobe-like intensity. The periodic interrupt of N20 can be modeled as a perceptual wave ambiguity that toggles back and forth between consciousness and unconsciousness at roughly 8 to 11 frames-per-second, or @8-11hz.5 Consciousness rises at the peak of each “wah” and diminishes in the valleys in between. On sub-anesthetic doses, N20 creates a looping effect where frame content overlaps into the following frame, causing a perceptual cascade similar to fractal regression. We can thus model the interrupt envelope of N20 as having a rounded attack, fast decay, low sustain, medium release, with an interrupt frequency of @8-11hz. Any psychoactive substance with a similar interrupt envelope will produce results that feel similar to the N20 experience. (Fig. 3) For instance, Smoked Salvia divinorum (vaporized Salvinorin A&B, or Salvia) has an interrupt envelope similar to N20, except Salvia has a harder attack, a slightly longer decay, a more intense sustain, a slightly longer release, and a slightly faster interrupt frequency (@12-15hz).6 These slight changes in the frequency and shape of interrupt envelope cause Salvia to feel more physically intense, more hallucinatory, and more disorienting than N20, even though they share a similar throbbing or tingling sensation along the same frequency range.
This actually seems to be important for showcasing what makes drugs with similar characteristic frequencies capable of feeling so different.
2 Hz Strobe
2 Hz Strobe + soft ADSR pattern
A really interesting research lead that is connected to the ADSR envelope of psychedelic tracers can be found in The Grand Illusion (Lehar, 2010), where cognitive scientist Steven Lehar narrates some of his experiences with LSD vs. LSD + MDMA. One of the things he discusses is the way that MDMA makes the experience jitter in a pleasant way that results in the LSD visuals becoming smoother (emphasis mine):
Under LSD and ecstasy I could see the flickering blur of visual generation most clearly. And I saw peculiar ornamental artifacts on all perceived objects, like a
Fourier representation with the higher harmonics chopped off
. LSD by itself creates
sharply detailed ornamental artifacts
like a transparent overlay of an ornamental lattice or filigree pattern
superimposed on the visual scene, especially in darkness. Ecstasy
smooths out those sharp edges and blurs them into a creamy smooth rolling experience
I would suspect that this distinction will become legible with the judicious use of ADSR envelopes. Below you will find a possible rendition of this effect:
10.3 Hz Strobe (maybe LSD)
10.3 Hz Strobe + soft ADSR pattern (maybe LSD + MDMA)
As we will discuss further below, a more creamy ADSR envelope may cash out in a more pleasant experience, whereas a sharper or spikier envelope may in turn create more harsh experiences.
Color Pulse/Negative After Images (Modifier)
The color pulse effect transforms the image’s color towards its opposite in the CIELAB color space with a given frequency. It modifies strobe, replay, and trails (in principle, there can be a different color pulse for each effect, but for now it modifies all three simultaneously).
23.6 Hz Strobe
23.6 Hz Strobe + 2 Hz Color Pulse
Unlike pulse, color pulse modulates the color rather than the brightness of the input. The way we determine what color to transform into is by going to the opposite side of the CIELAB color space. This accurately approximates the negative afterimage of any phenomenal color (such as yellow being the negative afterimage of blue, and green being the negative afterimage of red). In our current implementation, color pulsing affects strobe and replay quite differently. For replay, the effect is one where there are now versions of the ball (or image, more generally) that have the opposite color that are chasing the original ball, whereas for strobe the effect is that of giving a seizure to each of the recent snapshots of experience! See for yourself:
26 Hz Replay + 13 Hz Color Pulse
26 Hz Strobe + 13 Hz Color Pulse
In a future version of the tracer tool, color pulse may become a sub-property of each main tracer layer in the same way ADSR is a sub-property of the strobe and replay layers.
Color pulsing may be an important piece of the puzzle for understanding how otherwise similar drugs can have such dramatically different effects. Tentatively, color pulsing showed up as a distinction between DMT and 5-MeO-DMT according to one of the persons who submitted parameters (as you can see above in the replication section). For that person, DMT produced color pulses while 5-MeO-DMT did not. Of course this is just a sample size of N=1. But it seems like an important research lead if true! After all, DMT trip reports do talk of highly colorful hallucinations that typically involve the combination of colors and their opposites (e.g. “The wall looked like a Persian carpet with an alternating checkerboard pattern design of neon green and magenta light” – anonymous 10mg DMT), whereas most 5-MeO-DMT trip reports don’t feature color very much. In fact, 5-MeO-DMT trips are often in black and white, pure white, pure black, or “nothingness color”. We discuss the implications of this in more detail in the last section of this piece (GettingRealms from Time-Like Textures).
Face Value vs. Dynamic Feedback Model
It is important to point out that the tracer tool works under the assumption of linearity between the effects it models. In other words, each effect modifies the input in its own way, and the corresponding modifications are added linearly at the end. This does not need to be the case. And in fact, we must expect the brain to have a lot of complex non-linearities where e.g. the pulsing effect is then used in a replay loop which entrains a strobing pattern which focuses your attention and so on. This complication aside, there is a lot of value in postulating the simple model first, and then adjusting accordingly when it fails to model the more complex phenomena. When we get there, once we have identified particular drugs, doses, and combinations that produce strange nonlinearities, we can then build tracer tools that explore how the parameters of particular dynamic systems can best explain the empirical data. Until then, let us start mapping out the space with this (relatively) simple linear model.
I would like to highlight the fact that using the tracer tool can be very educational. Familiarizing yourself with the effects and their modifications will allow you to be able to describe in detail psychedelic tracers even without having to use the tool again. For instance, I find myself now able to describe what kind of tracer effect appears on any given replication or trippy video. For example, now that you have read about them, can you tell us what is going on in the following gifs?:
The Explanatory Power of the Time-Like Texture of Experience
Exotic Phenomenal Time
We have previously suggested that tracers in the most general sense (i.e. including tracers for emotions, thoughts, and all sensory modalities in addition to visual experience) are very important for understanding the time distortions one experiences in exotic states of consciousness. The overall idea is that the aspect of our experience that gives rise to the feeling of time passing is the result of implicit causality in the network of local binding connections, which we call the pseudo-time arrow (see a recent presentation about it). Don’t worry about the details, though. All you need to know is that here we model phenomenal time as the direction along which causality flows within one’s experience. And because this is a statistical property of our experience, it turns out that phenomenal time ends up being very malleable; it admits of “exotic phenomenal time” variants:
This framework can articulate what is going on when you experience crazy psychedelic states such as moments of eternity, time branching, time looping, and so on. Now, even these are just some of the possible ways in which the network of local binding connections can give rise to exotic phenomenal time experiences. In reality, because the pseudo-time arrow emerges at a statistical level in the network, one can have all manners of local pseudo-time arrows nested in complex ways, as briefly discussed in the presentation:
I will end by speculating: I just walked you through seven types of exotic phenomenal time, but if indeed [the experience of time] can be explained in terms of causality in a graph, then there are many other exotic phenomenal times we can construct. This is especially so when we consider the space of possible hybrid phenomenal times. For instance, where in some regions in the network we may find time looping, some other region might be a moment of eternity, and perhaps another region is branching, and you know, if you have a very big experience, there is no reason why you wouldn’t be able to segment different regions of it for different types of phenomenal time. This is not unlike, perhaps, how we think of Feynman diagrams, where this part of it here is moving forwards in time, this part here is doing a loop, this part here is branching… I think a lot of the topologies we see here could be used to represent completely new [hybrid] exotic phenomenal times.
Given the diversity of ways in which phenomenal time can be expressed in an experience, I will start talking about the patterns encoded in the pseudo-time arrow as the time-like texture of experience. This way, rather than assuming that one’s sense of time is globally consistent in a given way (e.g. as in “I am fully inside a time-loop”), we can discuss how various patches and components of one’s experience have this or that time-like texture (e.g. “my visual field was looping, but my proprioception was strobing and my thoughts felt timeless”).
As a generic effect, all psychedelics seem to increase the duration of qualia in one’s experiential field, leading to a buildup of energy. But the precise shape this takes matters a lot, and it is certainly different between drugs. An example pointed above is how LSD and DMT seem to produce strobe and replay patterns of markedly different frequencies. For DMT, the spatial and temporal frequency of the visual hallucinations is usually described as “very high”. Based on the replications thus far, along with personal reports from a musician I trust, DMT’s “characteristic frequency” seems to be in the 25 to 30 Hz range. In contrast, LSD’s frequency is more in the range of 15 to 20 Hz: both Dubois & VanRullen’s LSD tracer study and subjective reports I’ve gathered over the years point to the hallucinations of acid having this rough frequency. Hence, the very building blocks of reality of a high-dose DMT breakthrough experience consist of tiny time-loops and strobe effects interacting with one another, weaving together a hallucinated world with surprising levels of detail and intense freshness of experience (as all the time loops are “young” due to their short duration). Really, when you take a small dose of DMT and you see the walls tessellating into wallpaper groups, notice how each of the tiny “bricks” that make up the tessellation is itself a time loop of sorts! It is not a stretch to describe a DMT experience as a kind of complex Darwinian ecosystem of tiny coalition-based time loop clusters bidding for your attention (cf. Hyperbolic Geometry of DMT Experiences).
Taking this paradigm seriously allows us to interpret psychoactive effects at a high level in novel ways. For example, these are some of the general patterns we have identified so far:
Using the sound metaphor to restate the above, psychedelics introduce beats and recursion, dissociatives introduce reverb, and empathogens/valence drugs may affect the temporal blur of one’s experience. Thus, we arrive at a model of psychoactive substances that makes sense of their effects in the language of signal processing rather than neurotransmitters and functional localization. This sheds a lot of clarity on the mysterious and bizarre state-spaces of consciousness disclosed by psychoactive drugs and paves the way for a principled way of predicting the way drug combinations may give rise to synergistic effects (more on that below). More so, it lends credence to the patternceutical paradigm of drug effects.
Meditation: Insight and Concentration Practices
The pseudo-time arrow paradigm suggests that one of the ways in which meditative practices can switch one’s state of consciousness is by disrupting sober time-like textures and enabling exotic time-like textures not available to the sober mind (see also: The Neuroscience of Meditation: Four Models (Johnson, 2018)). My personal experience with meditative practices is limited, but I’ve had the pleasure of experiencing some strange effects so far. In particular, I would say that concentration practices seem to give rise to experiences with long and stable pseudo-time arrows – a peacefulness in which nothing is happening yet the flow of time is constant and rather uneventful. The phenomenal time of highly focused states of mind may be full of reverb, but I do not think it has crazy time loops. Moments of eternity and timelessness may be present at the limit here (e.g. moments of eternity and Jhanas may be deeply connected), though I will need more personal experience to say this with confidence.
On the other hand, insight practices such as noting meditation may have more of a replay and strobe effect. In particular, this may happen as a result of three core effects from this kind of meditation: (1) it stops you from dissipating energy across long narratives, (2) it recaptures the energy you were going to use for a longer narrative to feed the noting process instead, and (3) it entrains the rhythm of noting. This in turn (a) energizes a regular constant-frequency pattern (the frequency of noting) and (b) reduces the energy of every other rhythm, which in turn (c) canalizes sensory stimulation energy towards the brain’s noting frequency and all of its harmonics, which eventually leads to a high-frequency energized state of consciousness whose building blocks are tiny time-loops. These can synchronize and create experiences with characteristic time-like textures made up of such tiny energized loops. Hence, noting practice above some level of skill (e.g. with a noting frequency above 3 Hz) can be DMT-like to an extent (in light of thinking of DMT realms as made up of energized high-frequency mini-time-loops).
These experiences characterized by intense tracer effects are in a similar space as the strange temporal distortions that happen when you are dizzy (like when you stand up too fast or hyperventilate). The “loss of context” that results from this effect is due to the longest replay loops becoming too short to contain the necessary information to “keep you in the loop about what is going on”. Hence the confusion about who or what you are, what you are doing, and how you got here that happens when you are near passing out from standing up too quickly. That confusion takes place in an otherwise highly detailed and intense high-energy and high-frequency “rush” made of tiny time loops.
Thus, one of the gateways into altered states of consciousness via meditation with noting can be summarized as what happens when you induce a self-reinforcing pattern of strobing, replay, and pulsing that fully captures your attention. This process builds up a lot of energy, which one can only wield up to a point. When one fails to control it, the state decays into a series of tracer patterns that use the clean loop as its background reference. As this happens, one experiences a world whose building blocks are beautiful tiny jewels of attention, slowly decaying as one loses the ability to stay focused. The decay process also seems to do something good when properly orchestrated. Namely, as the decay process begins, one naturally experiences a Cambrian explosion of qualia critters eager to feed off of the negentropy generated, as thought-forms need attention to survive. This whole process, one could argue, lends phenomenological credence to the paradigm of neural annealing, where one’s brain uses a heating and cooling schedule to entrain brain-wide harmony.
In other words, with something like a noting practice, one ends up creating a world simulation whose building blocks are all embedded in a very tight time-loop, a wind-up universe of concentrated awareness. Perhaps we are going too far with this explanation. Either way, we really feel that thinking in terms of these generalized tracer dynamic patterns is an exciting new conceptual toolkit that allows us to describe the quality of exotic experiences that were hard to pinpoint before.
Three Exciting Possible Applications of the Tracer Tool: High-O-Meter, Synergy Quotient, and Harmonic World-Building
How high are you? It is often difficult to put a number on this question. But once we have established the parameters for different drugs (e.g. characterized DMT as living in a region of the parameter-space that is of higher frequency than LSD, etc.) we can show a series of gifs to someone and ask them to point at the one that best shows what tracers looked like at the peak of their experience. This way we can quickly estimate how high they got (at least visually) with a very simple question.
For example, we may find that the “modal response” to 50, 100, 200, and 300 micrograms of LSD looks as follow:
Simulated tracer for 50 μg of LSD
Simulated tracer for 100 μg of LSD
Simulated tracer for 200 μg of LSD
Simulated tracer for 300 μg of LSD
If this works, we would be able to sort research participants into one of these ranges just by asking them to point at the image that best captures their experience. Similar tools for other modalities could be used to obtain a global “highness score” meaningful across people.
(2) Synergy Quotient (orthogonality vs. synergy vs. suppression vs. harmonization)
What happens when you combine psychoactive drugs together? We have previously discussed in great detail what happens when you take combos of drugs from various categories (see: Making Amazing Recreational Drug Cocktails), but admit that there are huge puzzles and unknowns in this space. Of note is that some combinations give rise to synergistic effects (e.g. psychedelics and dissociatives), others blunt each other’s action (e.g. agmatine and nootropics), while yet others seem to create competing effects due to some kind of mutually-exclusive qualities of experience (e.g. salvia and DMT, a.k.a. “drugfights”). For an illustrative example of the third category, famous psychonaut D. M. Turner reports:
I smoked 30 mg. of DMT in three tokes, followed immediately by 650 mcg. of Salvinorin that I had preloaded in a separate pipe.
The effects were felt almost immediately. The first thing I noticed was a grid of crosshatch patterns. I had perceived something similar when using 2C-B with mushrooms, which I believed to be the result of using two psychedelics that were not compatible with each other. However, in this case the patterns were defined to a much sharper degree, and it seemed apparent that these two substances affect consciousness in differing ways that are not synchronistic when used together. Both the Salvia and DMT entities seemed to have been taken entirely off guard and had not been expecting this confrontation. These entities seemingly paid no attention to me as their attention was entirely fixed on each other. It soon became apparent that the two were going to battle, vying to determine who would have control of my consciousness.
We think that the tracer tool can be useful to quantify the degree of interaction between two drugs. For instance, say that drug A produces a robust 10 Hz replay effect, whereas drug B produces a 7 Hz Strobing effect. Would drug A + drug B cause a tracer that blends these two facets, or does it produce something different? If the combination’s tracers are different than the sum of its parts, how large is this difference? And can this difference be identified with a particular recursive stacking of effects, or as the result of a nonlinear interaction between dynamic systems? We believe that this line of research may be very illuminating.
Drug A + Drug B (“orthogonal”)
Drug A + Drug B (“suppression”)
Drug A + Drug B (“synergy”)
Drug A + Drug B (“harmonization”)
In the above example, we show what various possibilities for the result of drug combos may be. “Orthogonal” effects mean that the resulting tracer is the sum of the tracers of each drug, “suppression” means that one drug’s effect reduces the effect of the other, “synergy” means that the resulting effects are stronger than you’d expect by just linearly adding the effects of each drug, and “harmonization” refers to the possible slight-retuning of the characteristic frequency of each drug’s effect that allows for a consonant blending. How strongly the combo is from the predicted effect based on each drug would determine the synergy quotient of the pair.
A few possible (tentative) examples: alcohol + psychedelics give rise to orthogonal effects, opiates and psychedelics result in effect suppression, dissociatives and psychedelics result in strong synergy (not unlike what you get when you stack reverb and looping in music), and MDMA and psychedelics might result in harmonized tracers (hence the creamy and harmonious visuals of candy-flipping). We would love to see research tackling this question.
(3) Harmonic World-Building
Tinnitus is usually loud and distracting, but in addition, it can also be annoying and unpleasant. At QRI, we posit that the precise pattern of tinnitus—not only its loudness—has implications for how bad it is for someone’s mental health: dissonant and chaotic tinnitus might be worse than consonant and harmonious patterns, for instance.
In a similar vein, we think that the particular tracer patterns, over and above just their intensity, of perceptual conditions like HPPD probably matter for how the condition affects you at a cognitive, perceptual, and emotional level. Concretely, we would like to study how valence is related to one’s particular tracer patterns: we think that when psychedelic tracers feel good, that such positive valence may show up in the form of (a) harmonious relationships between the components of the effects, and (b) a sort of creaminness in the way the tracers come over time (as shown in the MDMA + LSD trip report by Steven Lehar).
We take seriously the possibility that something akin to the rules of harmony in music (see: by William Sethares) will have a showing in the way resonance in any experiential field cashes out into valence. In other words, the way patterns of resonance in the brain combine might be responsible for whether the experience feels good or bad. In particular, under psychedelics and other high-energy states of consciousness, one’s visual field is capable of instantiating visions of both tremendous beauty and tremendous terror. It is as if in high-energy regimes, one’s visual field acquires the capacity for creating pleasure and pain of its own (albeit “visual” in flavor!). While sober, one can get something akin to this effect, though only mildly in comparison: you can experience beautiful patterns by staring at a smooth strobe with eyes closed, or experience unpleasant reactions when the strobe shines at irregular intervals. The quality of the self-generated light-show in energized states of consciousness (such as a psychedelic experience) will likely have an impact on one’s sense of wellbeing. Is one’s inner light show all irregular, uncoordinated, sharp, and jarring? Or is it smooth, clean, robust, and soft? Based on the Symmetry Theory of Valence, one can anticipate that one’s tracer phenomenology feels good when it expresses or approximates regular geometries and bad when the implied geometries are irregular or disjointed.
Dissonant emergent pattern
Consonant emergent pattern
The creaminess of smooth ADSR envelopes would likewise prevent sensory and emotional dissonance by virtue of softening spikes of sensations. This, of course, is ultimately an empirical question. Let’s investigate it!
Final Thoughts: Getting Realms from Time-Like Textures
The complexity and information content of one’s state of consciousness as induced by a substance may depend on what fits in the repertoire of time-like textures of the state. For example, some states might be much more prone to generate quasi-crystals as opposed to crystals, as we argued in DMT vs. 5-MeO-DMT (Gomez Emilsson, 2020).
What are these crystals? One of the characteristic spatial effects of psychedelics is that they lower the symmetry detection threshold. This gives rise to the beautiful tessellations (at times Euclidean, at times hyperbolic (Gomez Emilsson, 2016)) everyone talks about. Analogously in time, psychedelics are notorious for creating time loops (cf. Going Loopy (Alexander, 2014)). In a deeper sense these are, we might argue, two facets of the same underlying effect. Namely, the creation of, for lack of a better term, qualia crystals. We can be cautious about assigning an ontological interpretation to qualia crystals; all we are proposing here is to accept them as phenomenological artifacts that tie together a lot of these experiential qualities. These gems of qualia come in many flavors, but they all express at least one symmetry in a clean and deep way. Whereas our experience of the world is usually made of a complex distribution of (tiny) qualia crystals which form the macroscopic time-like texture of our mind, we find in exotic states of consciousness the possibility of experiencing the refined, pure version. Timothy Leary in The Psychedelic Experience describes what he believes is the key existential conundrum close to the peak of an ecstatic trip:
Is it better to be part of the sugar or to taste the sugar?
In line with the neural annealing frame (Johnson, 2019), there is a very real sense in which slightly past the peak of a psychedelic experience you will find some of the largest, purest, most refined qualia crystals (at least relative to the human norm). And what this looks like will depend a lot on what the available building blocks are! The diversity of these building blocks makes the time-like texture of experience triggered by different drugs dramatically variable.
Some of the realms of experience are made with a time-like texture of interlocking time loops of different frequencies allowing you to experience the sense of “a big other”. In some other realms, the time loops are all aligned with each other, which makes self-other distinctions hard to represent and reason about. The various flavors for the felt sense of non-duality, for example, may correspond to different ways in which strobes, replays, pulse, etc. align perfectly to dissolve the internal boundaries used as building blocks to represent duality. At the extreme of “unification”, such as the state found in the 5-MeO-DMT breakthrough, one “becomes” a metronome whose tune is reflected faithfully everywhere in one’s experience, such that there is nothing else to interface with. Hence, one becomes “invisible to oneself”. To be in a state of near total oneness may entail the feeling of nothingness for this reason (thus the highest Jhanas being “nothingness” and “neither nothing nor something”).
This overall interpretative frame of exotic states as the result of time-like textures may show up empirically, too. One of the exciting early results, as mentioned above, is the report that while DMT creates complex positive and negative after-image dynamics full of color and polarity, the tracers on 5-MeO-DMT are monochromatic, meaning that one only experiences their positive after-image.
This alone may go a long way in explaining why the visual character of these two drugs is so distinct at their upper ranges. Namely, because DMT gives rise to complex checkerboard grid-patterns of overly-saturated colors intermingling with their polar opposites, whereas on 5-MeO-DMT, one often experiences an incredibly bright white light, or even a sense of translucid empty space, but no colors! The paradigm of using tracer patterns to make sense of states of consciousness would here suggest that a “breakthrough” experience can be interpreted as what happens when one’s world is saturated with the time-like texture characteristic of the tracer pattern of either drug. The realms of experience these agents disclose are the universes that you get when the building blocks of reality are those specific time loops and attention dynamics, leaving no room for anything that does not follow those “phenomenal time constraints”. When the dose is low, this manifests as just a gloss over one’s otherwise normal experience, a mere modifier on top of one’s sober reality. But when the dose is large, these time loops and attention dynamics drive the very way one’s mind constructs our whole sense of the world.
In this light, rather than thinking of exotic states of mind as places (as the “realm” metaphor alludes to), one can imagine conceptualizing them as ways of making sense of time. When you smoke salvia, you make sense of time in a salvia kind of way, which involves looping back chaotically in a way that typically results in losing the normal plot altogether and instead exotic narratives better fitted for the salvia attentional dynamics end up dominating the world-building process of the mind. Hence you end up in “salvia land”. Which is what you remember best. But the salvia land one ends up in is only a circumstantial part of the true story. The fundamental generator that is upstream of this realm would be the overall tracer pattern, the time-like texture of the experience: the neuroacoustic effect of salvia. He who controls the time-like texture of experience, controls the world-building process of the mind. Thus the paramount importance of understanding tracer patterns.
Do you want to collaborate on this project?
The Tracer Replication Tool is the first of a series of research tools we are creating at QRI specifically designed with psychedelic phenomenology in mind. The spirit of this enterprise is to identify the ways in which psychedelic states of consciousness can enhance the information processing of the mind in some ways. Rather than focusing on how information processing is impaired, we develop these tools with the goal of finding the ways in which it is enhanced (cf. psychedelic cryptography (Gomez Emilsson, 2015), psychedelic problem solving (Harman, 1966)). We take very seriously high-quality trips reports from rational psychonauts, which help us ideate tasks that are likely to show large effect sizes. Thus, rather than bringing traditional psychometric tools to the psychedelic space, we think that developing the tools to assess the psychedelic state in its own terms is more likely to provide novel and significant insights. We would love to have academic researchers include some of these tasks in their own study designs. Becoming familiar with the Tracer Replication Tool takes less than 10 minutes, and based on the pilot results, operating it during a psychedelic experience is possible for a good fraction of people under the influence of these substances. It would be amazing to have tracer replications included in psychedelic studies to come. If you are involved in psychedelic research and would like to use the Tracer Replication Tool or learn more about the toolkit we are developing please reach out to us! We would love to hear from you.
For Participants and Volunteers
There are several ways you can help this project. As a beta tester participant, you can use the tracer tool to replicate tracers that you yourself have experienced. There are three categories here (which you can specify at the point of submission when using the tool):
The case of HPPD and other non-drug induced tracers could be considered in this frame as well. For instance, we have been made aware that during the meditation practice of Fire Kasina, one experiences many pronounced tracers of various kinds. Thus, if you are currently experiencing meditation-induced tracers, you can submit parameters of the within trip kind. If you saw the bouncing ball (or other animations) during the meditation but have now exited your state, then you could submit a datapoint of the post-trip kind. And if you only have the recollection of tracers but did not see the ball at the time, then submit a retroactive datapoint. Likewise, HPPD and other tracer phenomena may come and go and their intensity may wax and wane, so these categories are also useful in such cases.
Please sign up to the QRI mailing list if you want to stay informed about the development of QRI’s Psychophysics Toolkit. We also want to emphasize, as we note in the Special Thanks section below, that this tool could not have been made without our amazing QRI volunteers. We are very eager to work with anyone with technical skills useful for this and related projects. If you would like to help us build these tools and advance our collective understanding of exotic states of consciousness, please get in touch. For more QRI volunteer projects see our volunteer page.
 A significant message of the book is that it is useful to conceptualize these rhythms as being the result of endogenous pattern-generating networks specialized to create specific frequencies, envelopes, and types of synchronization.
 “There are only two sources that control the firing patterns of a neuron at any time: an input from outside the brain and self-organized activity. These two sources of synchronization forces often compete with each other (Cycle 9). If cognition derives from the brain, this self-organized activity is its most likely source. Ensemble synchrony of neurons should therefore reflect the combination of some selected physical features of the world and the brain’s interpretation of those features. Even if the stimulus is invariant, the brain state is not. From this perspective, the most interesting thing we can learn about the brain is how its self-generated internal states, the potential source of cognition, are brought about. Extracting the variant, that is, brain-generated features, including the temporal relation between neural assemblies and assembly members, from the invariant features evoked by the physical world might provide clues about the brain’s perspective on its environment. Yes, this is the information we routinely throw away with stimulus-locked averaging.” (Buzsáki, 2006)
Special Thanks to: Lawrence Wu for implementing the current version of the tool. To Andrew Zuckerman, Quintin Frerichs, and Mike Johnson for a lot of useful ideas, conversations, and keeping the project afloat. To Robin Goins and Alex Zhao for getting a head start in implementing an earlier version of the tool. To the QRI team for encouragement and many discussions. And to the anonymous rational psychonauts and the HPPD sufferer for contributing pilot data with visual replications of their own experiences.
Atasoy, S., Donnelly, I., & Pearson, J. (2016). Human brain networks function in connectome-specific harmonic waves. Nature Communications, 7(1), 10340. https://doi.org/10.1038/ncomms10340
Luppi, A. I., Vohryzek, J., Kringelbach, M. L., Mediano, P. A. M., Craig, M. M., Adapa, R., Carhart-Harris, R. L., Roseman, L., Pappas, I., Finoia, P., Williams, G. B., Allanson, J., Pickard, J. D., Menon, D. K., Atasoy, S., & Stamatakis, E. A. (2020). Connectome Harmonic Decomposition of Human Brain Dynamics Reveals a Landscape of Consciousness [Preprint]. Neuroscience. https://doi.org/10.1101/2020.08.10.244459
Rudrauf, D., Lutz, A., Cosmelli, D., Lachaux, J.-P., & Le Van Quyen, M. (2003). From autopoiesis to neurophenomenology: Francisco Varela’s exploration of the biophysics of being. Biological Research, 36(1). https://doi.org/10.4067/S0716-97602003000100005
Lehar S. (1999) Harmonic Resonance Theory: An Alternative to the “Neuron Doctrine” Paradigm to Address Gestalt Properties of Perception. Available at http://slehar.com/wwwRel/webstuff/hr1/hr1.html
Lloyd, D. (2013). The Music of Consciousness: Can Musical Form Harmonize Phenomenology and the Brain?. Neurophenomenology. https://commons.trincoll.edu/dlloyd/files/2012/07/Lloyd-2013-Music-of-Consciousness.pdf
Ingram, D. (2018). Mastering the Core Teachings of the Buddha: An Unusually Hardcore Dharma Book. Newburyport: AEON Books. Available at: https://www.integrateddaniel.info/book
Dubois, J., & VanRullen, R. (2011). Visual Trails: Do the Doors of Perception Open Periodically? PLoS Biology, 9(5), e1001056. https://doi.org/10.1371/journal.pbio.1001056
Atasoy, S., Roseman, L., Kaelen, M., Kringelbach, M. L., Deco, G., & Carhart-Harris, R. L. (2017). Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. Scientific Reports, 7(1), 17661. https://doi.org/10.1038/s41598-017-17546-0
Kent, J. L. (2010) Psychedelic Information Theory. PIT Press. Available at http://psychedelic-information-theory.com/pdf/PIT-Print-Web.pdf
Lehar, S. (2010). The Grand Illusion: A Psychonautical Odyssey Into the Depths of Human Experience. Available at: http://slehar.com/wwwRel/GrandIllusion.pdf
Turner, D. M. (1996). Salvinorin – The Psychedelic Essence of Salvia Divinorum. Panther Press. Available at: http://www.lavondyss.com/donut/toc.html
Leary, T. Metzner, R. Dass, R. (1964). The Psychedelic Experience: A Manual Based on the Tibetan Book of the Dead. Available at: http://www.leary.ru/download/leary/Timothy%20Leary%20-%20The%20Tibetan%20Book%20Of%20The%20Dead.pdf
Harman, W. Fadiman, J. (1996). Selective Enhancement of Specific Capacities Through Psychedelic Training. Psychedelic Reports. Available at: http://druglibrary.org/schaffer/lsd/harman.htm
Gomez Emilsson, A. (2015). How to Secretly Communicate with People on LSD. Qualia Computing. Available at: https://gordigecr.it/2015/05/22/how-to-secretly-communicate-with-people-on-lsd/
Gomez Emilsson, A. (2016). The Hyperbolic Geometry of DMT Experiences: Symmetries, Sheets, and Saddled Scenes. Qualia Computing. Available at: https://gordigecr.it/2016/12/12/the-hyperbolic-geometry-of-dmt-experiences/
Gomez Emilsson, A. (2018). The Pseudo-Time Arrow: Explaining Phenomenal Time With Implicit Causal Structures In Networks Of Local Binding. Qualia Research Institute. Available at: https://www.qualiaresearchinstitute.org/s/The-Pseduo-Time-Arrow.pdf
Gomez Emilsson, A. (2020). 5-MeO-DMT vs. N,N-DMT: The 9 Lenses. Qualia Research Institute. Available at: https://gordigecr.it/2020/07/01/5-meo-dmt-vs-nn-dmt-the-9-lenses/
Alexander, S. (2014) Going Loopy. Slate Star Codex. Available at: https://slatestarcodex.com/2014/04/11/going-loopy/
Johnson, M. (2018). The Neuroscience of Meditation: Four Models. Qualia Research Institute. Available at: https://opentheory.net/2018/12/the-neuroscience-of-meditation/
Johnson, M. (2019). Neural Annealing: Toward a Neural Theory of Everything. Qualia Research Institute. Available at: https://opentheory.net/2019/11/neural-annealing-toward-a-neural-theory-of-everything/
If you want to use the software, please reference it by citing it in the following way (APA style):
Wu, L., Gomez Emilsson, A., Zuckerman, A. (2020). QRI Psychophysics Toolkit, Qualia Research Institute. https://qualiaresearchinstitute.github.io/psychophysics/
Gomez Emilsson, A. (2020, October). Modeling Psychedelic Tracers with QRI’s Psychophysics Toolkit: The Tracer Replication Tool. Qualia Computing.
[Epistemic Status: anecdotal data; this is not a list of “life hacks”; it is intended as a list of interesting research leads; don’t take drugs unless you really know what you are doing!]
Among some of the worst 2Cs (but perhaps not worst phenethylamines) we find:
In Anti-Tolerance Drugs we gave a list of drugs that, when taken in conjunction with painkillers and euphoric substances, can lessen, prevent, and even reverse tolerance. But “drug tolerance” is not a natural kind. Indeed, there are many systems of neuroadaptation that prevent drugs from exerting the same effect over time. Nothing makes this clearer than the typically life-long loss of “magic” to MDMA after a few experiences, which stands in contrast to the largely reversible tolerance to ethyl alcohol post-PAWS. Indeed, “drug tolerance” can mean tolerance to reduced action for: antidepressant effects (SSRIs), lessening chronic pain (opioids), increasing executive function (modafinil), enhancing motivation (amphetamine), “the magic” (ketamine, MDMA), the sense of unity and interconnectedness (LSD), otherworldliness (salvia), and so on. Indeed you can have a drug that generates tolerance to one of its effects but not others. For example, Slate Star Codex’s nootropic survey found that despite the common wisdom that prescription amphetamines stop generating a sense of euphoria after a while, most people who use them clinically for ADHD continue to experience an enhanced focus on the drug for many years. In this vein, the following anecdata highlights how anti-tolerance drugs have a much more subtle and multifaceted effect than just “reducing tolerance”:
In addition to all of what was said in Making Amazing Recreational Drug Cocktails:
[Excerpt from The Secret of Scent (2006) by Luca Turin, pgs 108-111]
Some Strange Clues
It has been said,* correctly in my opinion, that theories define facts as much as the other way around. Nowhere is this more true than in structure-odour relations, where all knowledge is anecdotal. Anecdotal evidence has a sort of slippery, jelly-like quality to it, and theories are needed to congeal the stuff together into single, solid facts. ‘Anecdotal’ is often used as a pejorative term in scientific circles, meaning unreliable. In practice it often means isolated, and therefore hard to assess. Think of a new field of science as a large jigsaw puzzle. Pieces are discovered one by one, and at first they are unlikely to fit together to make a picture. Things can look distinctly unpromising, sometimes for decades. But if you can bear the pain of feeling stupid and the humiliation of being wrong, anecdotal evidence is the call of the wild, the surest sign of the undiscovered. Columbus set sail on the basis of anecdotal evidence. The Mayan hieroglyphs were deciphered using anecdotal evidence. Life-saving remedies based on plants, such as aspirin and digitalis, were found by scientists who paid attention to anecdotal evidence.
Scientific problems typically go through three phases. In the first phase, a few bold explorers discover a new land and map out its basic features. In the second phase, boatloads of immigrant scientists arrive and colonize the land. In the third phase, statues are erected on town squares, sometimes to the original discoverers, more often to the able administrators who build the roads and railways. Smell, as it happens, did not follow this pattern. Scientific colonies never thrived on this particular island. Every few years, a new set of scientists claims to have cleared the jungle, but their cities are eventually overgrown and get lost in the weeds.
In smell, the difficulty is compounded by two additional factors, one obvious, the other more subtle. The first is the supposed untrustworthiness of the smell sensation I’ve mentioned earlier which makes strong men and women doubt their own noses. The second is that when facts, especially anecdotal ones, remain unexplained for long enough, a kind of question fatigue sets in, and they become accepted without being understood. The situation brings to mind a quintessentially British cartoon I saw once where a dinosaur strides past a terraced house, and a couple see it from their living room. Wife: “What was that?” Husband: “Oh, just one of those Things.” The fact that we can smell functional groups is just such a Thing.
Functional groups, as we have seen, are the specific structures of one or more atoms that are responsible for the chemical behaviour of a substance. Examples are thiols (-SH), nitriles (-CN), and aldehydes (-C(=O)H). The little hyphen indicates that these groups are, of course, attached to something and that the Something varies hugely. But the remarkable thing is that the Something matters little to the smell of the molecules. What gives the game away, especially to the casual observer, is the fact that types of smell are named after chemical groups: sulphuraceous, nitrilic, aldehydic, corresponding respectively to -SH, -CN, -(H)C=O. This is particularly clear in the case of -SH. All molecules which contain an -SH group smell (a) strong and (b) reminiscent of rotten eggs.
A word about the description ‘rotten eggs,’ since only a tiny minority of readers will be old enough to remember them. Eggs nowadays come with time stamps and serial numbers, so they seldom get a chance to rot. The rotten eggs smell is today more likely to be experienced in an oriental market (the durian fruit), by opening the gas tap on the stove (a small amount of an -SH compound is added to make sure we notice it), or best of all by going to an Indian store and asking for or ‘black salt’. Black salt, as its name does not indicate, is actually pink and is a type of rock salt that must come from Hell, as it contains ample amounts of Hell’s Kitchen smell, namely the HSH molecule. HSH is -SH repeated and smells bad twice over. Put some kala namak on your tongue and you will see what I mean. The first thing you will notice is that it reminds you mostly of a very intense hard-boiled egg smell. Clearly, eggs, even when fresh, are itching to fall apart. If you’ve done any chemistry at school, you will also recall the classroom when the teacher was making one of those stinks for which chemistry is famous. Beware though, the culinary satanism of kala namak is beguiling: a tiny amount in blackcurrant ice cream, strawberry daiquiris, coffee, and chocolate does wonders, as long as you don’t let anyone know you did it.
Do all -SH compounds smell identical then, i.e. of rotten eggs? Not a bit, actually: they smell of all manner of things, from grapefruit to garlic via blackcurrants, but they all have this sulphuraceous (i.e. from Hell) character. The grapefruit compound is particularly instructive. It is called pinanethiol. Thiol means -SH, so pinanethiol means pinane-SH.
Remove the -SH and the rest of the molecule (pinane) smells like pine needles, as it should, since pinane is a major component of turpentine oil, itself extracted from pine. Add the -SH back and, having smelled the pinane by itself and familiarized yourself with kala namak, you can clearly smell the parts of the molecule. That is to say you smell both the pine needles and the sulphur. Smell another very strong -SH compound like H₃C-SH, or methanethiol, for a few seconds till the nose (mercifully) tires of the hideous -SH smell, then go back to pinane-SH. Surprise! The sulphur note is now almost gone and the molecule no longer smells of pinane-SH, but instead smells of pinane tout court. This means that this molecule smells like the sum of its parts. In other words, -SH is a primary, though the other smells are not. But how does that work? How do we know what parts it’s made of? This, as we shall see, is the greatest mystery of smell. Looking for an answer will take us amazingly far afield.
* Paul Feyerabend, among others, convincingly argued this view in Against Method, required reading for those who believe the scientific method is something which can be written down and followed like a recipe.
On a recent conversation I had with Luca, I shared with him the fact that there are anti-tolerance drugs that can lessen (and even reverse) the physiological tolerance to drugs such as painkillers. He was seriously surprised by this fact. Despite spending a whole career studying biological regulatory systems, he had never in his life heard of anti-tolerance drugs in academia. Upon hearing this, he shared that in his experience, most of the innovation in science comes from people who work hands-on in the field, as this exposes them to a much broader evidential base than you would encounter when doing research in a strictly theoretical way.
Thus, he has learned far more about consciousness from psychonauts than he ever has from academic psychopharmacologists, and has learned more about electronics from radio amateurs than professional electrical engineers. In other words, the people who actually tinker with the inner mechanisms of the systems they’re interested in are the people to ask for “weird and novel phenomena”, rather than (only) those who study the field academically angling for a university post or a narrow job in the industry. Same, of course, with the science of smell: actually tinkering with aromachemicals can give rise to discoveries one may never stumble upon by merely studying scent receptors in a lab. Needless to say, the best outcomes will come from seamlessly blending both worlds; but for that to happen we will have to embrace phenomenological reports as acceptable leads for research in science.
“Ideology has two meanings- actually, most social terms have two meanings, one for the traumatized and one for the non-traumatized.”
“You know the old adage about monkeys typing into infinity, and the question about whether they would eventually produce Hamlet? I think that maybe we are those monkeys, and we’re producing countless Hamlets every single day.”
“Reality is very weird, no doubt. At the same time, it is easy to get wrong ‘what kind of weird’ reality is.”
“It is not true that suffering ennobles the character; happiness does that sometimes, but suffering, for the most part, makes men petty and vindictive.”
December 13th 2019
In a different timeline, I open a high-class experimental qualia-focused restaurant. There is only one kind of meal every month, and it is a challenge to finish it. Only 10% of people manage to do so. On March of 2022, the menu consists of:
If you finish the entire thing (which usually takes about 5 hours total) they take a photograph of you and “keep it to themselves”. No, there is no “victory board”. They just want a picture of you.
January 6th 2020
Favorite essential oils at the moment: Freesia, Violet, and Pear. It turns out Freesia was a predominant note in Dior “Addict 2“, a perfume I fell in love with when I was a teen. Violet is “ethereal” in that it feels strangely anesthetizing (the ketamine of smells). Pear is lovely.
An interesting blend with “emergent” characteristics: Freesia, Pear, Violet, Sunflower, Azalea, and Patchouli. Very high valence mixture that has a novel feeling that does not seem to come from the ingredients. #HighEntropyAlloy #HighEntropyScent
January 8th 2020
In sound and sight, it seems that there is an inverted U curve relationship between stimuli entropy and the entropy of the experiential response. White noise may be- objectively- the way to cram in as much information as possible into a waveform. But perceptually, white noise is more like its own (neutral valence, indifferent) tone. Likewise visually, if you crowd your images way too much you can’t actually understand its meaning and true complexity. Perceptual complexity response is maximized in the middle, where you achieve “peak useful entropy”.
More so, extremely entropic stimuli can be used to “mask” any input by adding a dose of white noise or visual static. That’s how you can degrade the valence of something when you don’t know what kind of unpleasant input you will get in advance. White noise drowns out both construction sounds and baby screams. It’s a “universal diluter”, so to speak.
And so it seems that this is the case with smells too. If you combine any 40 (42?) scented molecules that are as different as possible, you get as a result a generic smell with neutral valence that is not distinctive at all. If you make a different 40-scent mixture with completely different molecules, it also smells the same! They call it white noise scent, or “Laurax”*.
In other words, the “high-entropy alloys” of smell may only really pay off in the range of 5 to 15 different molecules, where (perhaps) we maximize the experiential “character” of the resulting fragrance.
Now, of course commercial perfumes in practice do have dozens if not hundreds of aromachemicals. But their absolute “scent entropy” is probably not that high. Why? First, the entropy is reduced by the fact that most perfumes do concentrate on a few core notes; the many other notes are usually small additions and tweaks. And second, the perfumes are usually made with relatively few categories of smells blended together (musky, citrus, and flower could be one, or green, ozonic, and non-citrus fruity another, and so on). Additionally, to get true white noise smell you need to also add negatively valenced scents, which are rarely used in actual perfumes. I do wonder, though, if the perfume industry has a sense of the “scent entropy” of their various perfumes, and if having a measure of it would perhaps improve their ability to hone in on blends that have unique emergent characters without relying entirely on heuristics and trial and error. Or how about a portable “scent-entropy-o-meter”? I bet it would find some very useful applications.
January 10th 2020
Of all the industries, I get the impression that the perfume industry is ahead of the curve when it comes to incorporating hedonistic utilitarian notes into its embedded ideology.
January 11th 2020
Cilantro tasting like soap to 10% of the population is just the tip of the iceberg.
January 13th 2020
What are your favorite perfumes?
(and if it’s not impossible to describe – why do you like them so much?)
Addict 2 by DiorEros pur femme by VersaceLight Blue by Dolce & Gabbana
January 14th 2020
Scent combinations with unusual emergent characters that are “more than the sum of their parts” I have discovered so far:
In each of these cases, combining in roughly equivalent intensities (i.e. 50-50 ‘equipotent’ mixtures) seems to give rise to qualities that are not present in either of the two scents. This is relatively rare, IMO. If you combine, e.g. lilac and jasmine, you just get something that smells like “lilac and jasmine”. But the four combinations above seem- to me- to give rise to new exotic qualia varieties.
An accord is more about getting rid of the individually distinguishable component scents. The end result, however, is one of a “generic” scent within a given category (or subcategory). For example “white flower accord” or “citrus accord” are common. And although you can distinguish between two citrus accords, they don’t really have unique character – at least not more than e.g. various kinds of brown noise have a unique character. The combinations I’m mentioning are not just ways of creating a category blend so that other elements of the perfume can be more noticeable. Rather, they are on their own uniquely characteristic, much like other pure essential oils.
If you mix a wide enough variety of flowers you inevitably get a flower accord. To get a new qualia type emergent you need something else. (I should add I’m new to the field and have a lot to learn).
I’m developing a way of explaining what a scent is like at a glance with relatively few parameters. One of them is category entropy, meaning how close a given category in the scent is to the maximally blended version of it (i.e. a fully generic “flowery” scent has maximum category entropy).
Then another parameter is the “global entropy” which describes how close the scent is to total white noise scent.
So we start by saying e.g. perfume X is “50% of the way to white noise scent and its distribution of core categories is 30% woody, 30% floral, 20% fruity, and 20% citrus”, then we zoom in to each category and describe its category entropy and salient notes: “the floral entropy is 40%, and the 60% remaining is shared in equal measure between rose and azalea” (repeat for each category).
Additionally, another important thing to add is if there are “note to note interactions”, which in my (limited) experience happens with some pairs. Maybe 10% of them, but I don’t know for sure. But you could describe them with lines between individual notes in a diagram. To round it all out, you also would point out the note accords that work as “phases” in the overall scent (drawing inspiration from high entropy alloys – an alloy that does not make a single crystal structure is called “multiphasic”). E.g. mango + patchouli + cinnamon + jasmine tends to produce two phases, a mango + cinnamon phase that toggles in your attention with the jasmine + patchouli phase. Finally, we would also note “valence inversion” effects that happen when there are combos of scents that when placed together give rise to a flipped valence (also a rare effect, IME).
For a slightly higher level of resolution, we would break down each category into subcategories and then describe the entropy of each. E.g. a floral perfume could be 80% of the way to maximum floral entropy in the “white flower” subcategory but only 10% of the way to maximum entropy in the “powdery flower” category.
This would allow us, I think, to put our finger on many scents that are hard to describe otherwise. Indeed, a lot of sophisticated perfumes, IMO, are playing a lot with different shades of high entropy, so talking about them in terms of notes like jasmine or amber is very misleading. It’s like calling a certain kind of brown noise “closest to a guitar sound” because one lacks words for describing noise profiles.
January 23rd 2020
So we know that we can get “white noise smell” by combining 42 scents of completely different kinds at the same time. This maxes out the “scent entropy” (aka. “Laurax”).
If you combine 42 different flower scents, however, you get a maximally generic “flowery scent”. I call this “category collapse”.
Now some scents have what I call “special effects”, which are category-neutral qualities. An example is the ‘bitterness’ of grapefruit, which although is often associated with fruits, can occur in entirely different categories too.
So I thought: what if we try to combine scents from as many categories as possible that all share the same special effects? I call this “scent factorization”. Namely, you try to get “special effect + Laurax” by canceling out everything but the special effect.
In this case you will see that geranium is almost like “the grapefruit of flowers” in that it is flowery in nature but still shares the same “bitter” quality as grapefruit (albeit at a different frequency – yes scent frequencies are a thing, but that’s a story for another time). Likewise, cedar-wood is the most grapefruit-like wood I’ve smelled.
In this case, again, you’ll see that sandalwood is the most “creamy” of all woods (as far as I have tried), fig is the most creamy of all fruits, and so on.
But this is just the start. What other scent factorizations could we try? I’d say we could aim to have the special effects of “ozonic”, “green”, “ethereal”, “powdery”, “acrid”, “cloying”, and so on factorized. Each deserves to become its own perfume in my up and coming new line of high end perfumes called “The State-Space of Scents” (for the consciousness connoisseur).
February 2nd 2020
The Qualia Review is a tongue-in-cheek program where you will get non-expert opinions about the quality of experiences by people who really care about consciousness:
In each episode, Andrés Gómez Emilsson (gordigecr.it) reviews a particular qualia variety (i.e. category of experience) with a co-host (in this episode Victor Ochikubo).
In this first episode we review women’s perfumes. In particular, we review (from worst to best):
La Panthére by Cartiere (EDT)By Invitation by Michael Bublé (EDP)Guilty by Gucci (EDT)Brit Rhythm by Burberry (EDT)Jolie Fleur Bleue by Tory Burch (EDP)Rose Goldea by Bvlgari (EDP)Daisy Love by Marc Jacobs (EDT)Valentino by Valentino (EDP)Amazing Grace Ballet Rose by Philosophy (EDT)Light Blue by Dolce & Gabbana (EDT)Eros by Versace (EDT)
You will notice that this is unlike any other review of perfumes. This is because the review here provided addresses the following three aspects of scents:
Thus, we share an entirely new angle on how to describe the ineffable. Namely, the hard-to-put-your-finger-on elusive subjective quality of scents can finally be grounded in terms we can all understand (with a modicum of shared background assumptions).
February 5th 2020
Three scents that are surprisingly similar to strawberry (based on my personal experience with essential oils):
In fact, following the “scent factorization” concept – if you make a mixture of these three scents the resulting oil smells almost exactly like strawberry cake. Strange!
February 9th 2020
I love this video! The idea that the information content in a perfume could possibly fit so much phenomenal detail is enticing, albeit perhaps a bit optimistic.
In the interest of honesty, out of the 15 or so women’s perfumes I’ve experienced deeply so far, La Panthere by Cartier is the worst by quite a long shot.
I don’t mean this to troll! I am serious. I still don’t quite know why I feel it as so unpleasant. I think it has to do with its very high entropy quotient, and the fact that it centers around gardenia, which is my least favorite flower. It feels predatory – and perhaps the perfumist did succeed at telling a story. Too bad I aim to reprogram the biosphere so that predation is a long-forgotten nightmare of our ancestral Darwinian environment of adaptedness. So long! We should aim to transform scent exploration from its current state of commercialism mixed in with weapons of sexual conquest, and push it into new frontiers… the exploration of the state-space of consciousness, valence research, perhaps even energy parameter modulation! The future of scent qualia research is wide open.
The Qualia Review is a tongue-in-cheek program where you will get non-expert opinions about the quality of experiences by people who really care about consciousness:
In each episode, Andrés Gómez Emilsson (gordigecr.it) reviews a particular qualia variety (i.e. category of experience) with a co-host (in this episode Victor Ochikubo).
In this second episode we review men’s perfumes. In particular, we review (by order of appearance):
CK2 by Calvin Klein (EDT)Pasha de Cartier Edition Noir by Cartier (EDT)Virtu by Vince Camuto (EDT)21 Le Fou by Dolce & Gabbana (EDT)Le Male by Jean Paul Gaultier (EDT)Scuderia Ferrari Light Essence Bright by Ferrari (EDT)Jimmy Choo Man Blue by Jimmy Choo (EDT)1 Million by Paco Rabanne (EDT)Terre D’Hermes by Hermes (EDT)Invictus by Paco Rabanne (EDT)Bleu De Chanel by Chanel (EDP)
In this episode we also discuss the way in which an enriched conception of art could helps us reformulate the artistic potential of perfumes. We make allusions to the 8 models of art discussed in a previous video:
February 10th 2020
It’s very sad that there is a huge paywall for scent qualia. It’s your birthright to know what they smell like!
February 11th 2020
~120 essential oils and ~40 perfumes (ordered by categories and general character).
This is the dataset my brain has been training over to interpret the state-space of scent qualia for the last month and a half. This is still amateur level – but I can nonetheless confidently say that I now understand scent qualia at least 50% better than I did last year.
I would still appreciate specific suggestions for essential oils or perfumes to get that are very unusual or characteristic. I continue to be surprised by the uniqueness of oils, fragrances, and mixtures I haven’t tried before.
Also: drastic income inequality is a massive tragedy, no doubt. But why are people not talking about qualia inequality? I wish everyone was as qualia-rich as I am right now. I’m happy to share some scents with people who feel qualia-deprived; just come to the Bay and give me a call. 🙂
Ps. Peony is an incredibly versatile low-entropy flower scent with a creamy strawberry-like effect. I kept reading about how this or that perfume has peony in it, but it really took me owning an essential oil of it to grok the type of qualia peony is all about. Someday there will be a monument built to celebrate the qualia variety disclosed by peony formulas. I’m pretty sure of this.
February 14th 2020
People say “a blind buy” when they talk of buying a perfume they haven’t smelled. Shouldn’t it be more appropriate to say an “anosmic buy”?
February 18th 2020
In order to survive the apocalypse, having a “blue” fragrance on hand will become very useful. I suggest “Nautica Voyage“.
February 21st 2020
Very interesting! Two followup questions: (1) does it replicate on a larger sample size? and (2) is the baserate of different sexual orientations of anosmic people statistically different than those of the general population?
Gay men showed a strong preference for the body odour of other gay men in the scientific test of how the natural scent of someone’s body can contribute to the choice of a partner.
Although previous studies have shown that body odour plays a role in making heterosexual men or women attractive to members of the opposite sex, this is the first study that has investigated its role in sexual orientation. Charles Wysocki of the Monell Chemical Senses Centre in Philadelphia, a non-profit research institute, said the findings underline the importance of natural odours in determining a sexual partner whatever the sexual orientation of the person involved.
“Our findings support the contention that gender preference has a biological component that is reflected in both the production of different body odours and in the perception of and response to body odours,” Dr Wysocki said.
February 25th 2020
February 27th 2020
Jasmine, Tuberose, and Gardenia: the Dark Triad of White Flowers. Beware! They are treacherous, envious, and guileful. DO NOT TRUST. They will ruin your perfume with their high-entropy indolic ‘broad spectrum scent noise’. Deranged, distracting, and disingenuous. #FlowerProblems
March 12th 2020
Why you should not insufflate ketamine: (1) it can irreversibly damage your bladder and cause very serious untreatable chronic pain, (2) it can damage your liver, also very painful, but above all (3) it will slowly degrade your ability to experience scents! Not worth it IMO!
Cocaine is well known for causing anosmia in regular users. I suspect we are going to see a wave of anosmic people as ketamine becomes more popular. Don’t be a victim. “Remember kids, don’t insufflate drugs – either eat them or inject them” would be my DARE go-to phrase.
March 16th 2020
Running out of hand sanitizer but you are fab and have a perfume collection? Use some cheap perfume instead! It’s usually 70+% alcohol.
March 22nd 2020
Factoring in the loss of precious qualia would make this epidemic even worse. This year I’ve finally begun appreciating the state-space of scents. I’m heartbroken to learn about this effect. So much qualia in potentia that might be lost!
March 23rd 2020
We should emphasize the possibly of life-long loss of smell in order to get more young adults onboard with strict social distancing measures. A 20-something person might not fear a fever, but they may fear “having less sexy sex and enjoying food less for the rest of their lives”.
March 26th 2020
Sense of smell over the years. People under 40: please do yourself a favor and get some nice scents so you enjoy them while you are still sensitive to them. It’s always a tragedy not to use a qualia variety and then lose it. #qualia #scent #aging #valence #bliss #WeAreTheQualia
March 29th 2020
This is the future – in 2010 I was saying that in the long run humanity will need to adopt entirely new and seemingly extreme measures against contagious diseases.
Nasal filters (aka. “nose condoms”) were one of the ideas I was considering at the time. Reality is now catching up with fiction.
Why adopt extreme measures? Because we haven’t seen anything yet. The possibility of rational virus design and the political will to invest in innovative weapons means that sooner or later we will encounter things with a case fatality rate > 80% and R0 > 4. Nothing short of large-scale contact network engineering and the widespread use of tech like nasal filters can really work against those long-tail risks.
Perhaps in the future going out without nasal filters will be considered as reckless as today it’s considered having unprotected sex with a random stranger. #NasalFilter #TheNewMask #PM2point5
April 8th 2020
1. – Ferrari (amazing sharpness and cute Sicilian dry-down)
2. Monserrat – Bruno Fazzolari (incredible grapefruit punch and bitter-sweet resonance)
3. Born – Adidas (a cheap but highly rewarding lavender rhubarb scent).
April 21st 2020
Haven’t posted about scents in a while; I’m still actively researching this fascinating qualia variety (better do so while I still have scent qualia, which may of course go away if/when I acquire COVID-19).
I’ve developed a lot of new vocabulary to talk about scents. In particular, I like to break down a scent in terms of entropy (how close to ‘white noise scent’ it is), category distribution (% woody, citric, fruity, etc.), category-specific entropy (e.g. 70% of the way to ‘generic flowery’), specific notes (e.g. 10% rose), and of course, “special effects” (such as “creamy”, “powdery”, “bitter”, etc.).
A recent “special effect” I’ve explored is the rather peculiar feeling that the scent is “flammable”. For example, gasoline has it, and so does ethanol. It is similar to the feeling you get when you inhale nitrous oxide. A kind of fascinating gas-like intoxicated state that produces spatiotemporal confusion and a sense of resonance. Of the scents I currently have access to, 100% pure Neroli essential oil strongly triggers this particular special effect. Neroli has that strange “flammable” quality, perhaps an octave or two in pitch higher relative to gasoline. It’s equally enthralling as the smell of gasoline (for those who like it) but much more dinner-party-friendly.
Anyway, with this “flammable” special effect in mind, I’ve been exploring what can be added to it in order to create beautiful scents. Last night I found a combination that made me really happy. It consists of equal (intensity-adjusted) parts of:
It is sweet, sour, and gasoline-like in an unexpectedly euphoric way. I highly recommend this quale. I very much like its vibe. Meet me there.
April 28th 2020
First I tried essential oils. Then I tried perfumes. Now I’m entering a third phase in my “scent literacy” journey: pure molecules.
I have 50 pure perfume ingredients in an air-tight container now. And I have been trying out a couple each day in a systematic way in order to map out the state-space of scents.
One core insight so far:
Essential oils are extremely rough approximations for “building blocks” of scents. Perfume notes are often described in terms of fruits, woods, flowers, animalic sources, etc. But “apple” is not a natural unit of scent qualia. Although there is a general “apple vibe”, in reality that vibe can come from any of 20 or so different molecules. Additionally, many molecules that have an apple vibe do not even appear in biological apples (and vice versa). I’ve so far tried two apple-vibe molecules:
In other words, I’m learning that pure molecules are indeed more “simple” than essential oils by far. They feel very specific and low-dimensional rather than voluptuous and scenic. But despite their relative simplicity, they are still not “categorically pure”. A single molecule can smell woody, fruity, and camphorous all at the same time. Part of the story is likely that a single molecule can have a broad spectrum of receptor affinities. But even if only one scent receptor were to be activated, perhaps the resulting experience would also not be uni-categorical.
The fascinating implication here is that scents that feel very uni-categorical (e.g. pear essential oil being unequivocally “fruity” with no hint of floral or woody) are more likely to be compositions of many molecules!
Each uni-categorical accord is made by mixing many molecules that all share the same “main vibe” but have different “secondary traits”. This way the accord lets the secondary traits “cancel out in white noise scent” while the main vibe is additively compounded into a broad-spectrum power-punch of a single category, like fruity (reminiscent of “scent factorization”, which I’ve described in previous posts).
May 2nd 2020
“You don’t need to be phenomenally rich in order to be phenomenally rich!”
I’m an advocate of high-dose behavioral enrichment (I talk about it at 22:16):
May 3rd 2020
Ellena will dip a touche into a molecule called isobutyl phenylacetate, which smells vaguely chemical and nothing else, and another into a synthetic molecule whose common chemical name is ethyl vanillin. (A rich gourmandy vanilla molecule, its IUPAC name is 3-methoxy-4-hydroxy benzaldehyde, and it is the heart of Shalimar.) He puts the touches together and hands them to you. Chocolate appears in the air. “My métier is to find shortcuts to express as strongly as possible a smell. For chocolate, nature uses 800 molecules, minimum. I use two.” He hands you four touches, vanillin + natural essences of cinnamon, orange, and lime—each of these has the full olfactory range of the original material—and you smell an utterly realistic Coca-Cola. “With me,” says Ellena, “one plus one equals three. When I add two things, you get much more than two things.”
He will hand you a touche that he has sprayed with a molecule called nonenol cis-6, which by itself smells of honeydew melon or fresh water from a stream. He’ll then hand you a second touche with a natural lemon on it, direct you to hold them together now, and suddenly before you appears an olfactory hologram of an absolutely mesmerizing lemon sorbet.
The explicit point was not to create a thing but an illusion of that thing, an olfactory alchemy. The point of Nil was not to create a green mango but the illusion of a green mango.
Junior perfumers discover that Vetiver Huile Essentielle from Haiti smells like a Third World dirt floor and Vetiver Bourbon from Isle de la Réunion smells like a Third World dirt floor with cigar butts. (They hope to do something wonderful with the cigar butts.) They learn, as Ellena knew from decades of work, how to create the illusion of the scent of freesia with two simple molecules, both synthetics: ionone beta + linalool. And orange blossom: linalool + anthranylate de methyl, which by itself smells like aspirin. The classic Guerlain perfumes often used a molecule called styrex, which smells of olive oil pooled on a table in a chemical factory. Add phenylethylic alcohol and you get lilac. Add the smell of corpse (indoles), you get a much richer lilac. And you can give your lilac, freesia, and orange blossom a variety of metallic edges: Add allyl amyl glycolate, you get a cold metal freesia. Add amyl salycilate, and you get a freesia with the smell of a metal kitchen sink dusted with Ajax powder. Aldehyde C-12 lauric adds an iron with a bit of starch still on it.
May 8th 2020
Excerpt from Luca Turin and Tania Sanchez’s 2008 perfume guide:
The last decade has seen the unfortunate flourishing of a dismal genre, the fragrances for men and women who do not like fragrance and suspect that none of their friends do either. The result has been a slew of apologetic, bloodless, gray, whippet-like, shivering little things that are probably impossible, and certainly pointless, to tell apart. All fragrances whose name involves the words energy, blue, sport, turbo, fresh, or acier in any order or combination belong to this genre. This is stuff for the generic guy wishing to meet a generic girl to have generic offspring. It has nothing to do with any other pleasure than that of merging with the crowd. My fondest hope is everyone will stop buying them and the genre will perish. Just say no.
Lastly, and by way of contrast, remember that perfume is foremost a luxury, among the cheapest, comparable to a taxi ride or a glass of bubbly in its power to lift the mood without causing subsidence the morning after. Wear it for yourself.
May 13th 2020
The perfume Tommy Girl just registered as an outlier to my nose. It registers as high in valence as Bleu de Chanel and Bright Neroli by Ferrari. Extraordinary perfume. 10/10 #ScentQualia
May 27th 2020
One of the most interesting lines of evidence pointing in the direction of the Symmetry Theory of Valence is how in the neighborhood of the peak of high-energy neural annealing events one can often glimpse states of consciousness with a characteristic “full-spectrum of qualia” property.
This may happen nearing the peak of a strong LSD trip, during intense Jhanic concentration, Fire Kasina practice, or even just spontaneously (though extremely rarely).
At the actual peak of the annealing process you are likely to arrive at a “moment of eternity“- itself extremely high-valence- where the symmetry is so complete that it becomes impossible to distinguish between self and other, before and after, or even left and right (this is a phenomenal property of peak valence states, and not proof of Open Individualism and non-duality per se, even though most people tend to interpret such experiences that way).
The “Rainbow God” phenomena lives at the edge of such peak valence states.
Timothy Leary in “The Psychedelic Experience” says that as you approach the highest bardo you are given the choice between “tasting sugar” and “being the sugar”.
The former is close to the peak of the annealing process, where there is enough asymmetry in the state for you to be able to encode information and distinguish between past and future, self and other, etc. and thus able to experience a projective world-simulation and the illusion of a self that “experiences it”. At the top of the annealing process, however, the extreme symmetry does not allow you to do that. The valence is almost certainly higher, though the degree of consciousness is arguably lower. You are “the sugar” rather than “tasting the sugar” (i.e. you are luminosity rather than a constructed world-simulation “experiencing luminosity”).
Stunningly, this edge between perfect symmetry and its surroundings in configuration space often shows extreme levels of qualia diversity. This is an empirical observation you can verify for yourself (or you can trust me, find others who have experienced it, or derive it from first principles).
What is it like? At this boundary between quasi-perfect symmetry and perfect symmetry you experience rainbows with all the phenomenal colors in the CIELAB color space (and perhaps some other colors that you only see in heaven, like blue-yellow and red-green, which require enough energy to overcome the lateral-inhibition opponent process going on in the cortex at all other times). You experience a sense of “all possible temporalities”. A sense of “all possible scents”. And a sense of all possible spatial relationships at once.
If you get any closer to the peak of annealing, the rainbows collapse into luminosity, the scents into a sense of presence, the temporalities into a sense of eternal now, and the possible feelings of space into a projective-less “view from nowhere”. The combination of all qualia values of each qualia variety somehow, incredibly, seem to add to zero. But not any kind of zero. A special “Zero” perhaps equivalent to “no information but awake”. (Cf. David Pearce’s Zero Ontology for a possible grounding of this state in fundamental physics.)
Yes, this is very much a real state of consciousness. It is profound, and extremely important.
I call it the “Rainbow God” state of mind. I do not know how to reliably induce it, but I do know that it is likely to have extremely deep computational, ethical, and experiential properties capable of advancing our understanding of the nature of the state-space of consciousness. I just figured you should know this exists.
June 2nd 2020
Really excellent presentation about the biological and physical underpinnings of scent. It’s a bit on the long end (50 minutes) but you can get 80% of it by just watching the first 12 minutes. It’s really good! So much information…
For instance: did you know there are about 400,000 scented flower species in the world? I struggle to come up with more than 30 flowers off the top of my head (up from 5 just less than a year ago). The remaining 399,970? Who knows what they smell like. We don’t have words for these smells… is it “rose” or “jasmine” smell? Good luck using that kind of ontology describing the space of possible flower smells.
Also: it turns out that volatile molecules don’t diffuse very effectively. So that’s why you get “whiffs” of scents – for the most part, in the wild, air is a very non-homogeneous gas, with all kinds of pockets with specific linear combinations of aromachemicals. Hence why holding two essential oils side by side doesn’t give rise to a proper mixture between them. You need to literally mix the oils and then smell the mixed result if you want to actually know what the combination is like. Otherwise you will get a whiff of one, a whiff of the other, etc. with a Poisson-like distribution. This also reminds me that: we have an olfactory bulb in each nostril! So if you apply one scent in one nostril and another scent in the other nostril, you will get a kind of “bi-scent rivalry” [binosmic?] similar to what you get when you see one image with the left eye and one image with the right eye (i.e. “binocular rivalry”).
I do think that “digital smell” is possible (unlike the presenter). But it will require us to describe each molecule in terms of their ADSR patterns for each of the basic scent qualities (that is, to describe how the sweetness develops across time – its attack, decay, sustain, and release – and do the same for each core qualia scent dimension). Without taking into account the ADSR envelope for each molecule, the mixtures will be uneven.
The lowest-hanging fruit would be to use a non-negative least squares regression that minimizes the error for the envelope of each of the core qualia scent dimensions. Hence, the molecular spectrum is not enough – the non-negative least squares requires pattern-matching across the entire temporal envelope of each dimension. IF we do this – then digital smells might be possible after all (IMO!).
June 3rd 2020
There are a TON of questions whose real answer is: “Bleu De Chanel”. Think about it.
“Bleu De Chanel” spans eons and eons of subjective time – the grapefruit/incense/amber vibe ringing on and on throughout eternity. That’s how large it ALL is.
You can get a powerfully believable Smirnoff Lime impression with as little as a few drops of citral and aldehyde C-12 in an ethanol + water mixture. Amazing what passes as a “fine drink” these days.
“At least add some linalool to make it worth it” – would be my recommendation.
Note to self: by virtue of their sharp smell, aldehydes are powerful high-frequency psychoactives.
June 6th 2020
Note to self: Smelling a bunch of aldehydes over and over for several days in a row causes bad headaches. Use them only occasionally from now on.
June 13th 2020
I asked a DMT being about the nature of scent qualia. Its response: “One hint: are you sure it’s only one kind of qualia?”
Luca Turin, the quantum neurobiologist who has done research on the vibration theory of olfaction (showing “we can smell functional groups”) told me that if perfumes are tomato soups, the money is in “making the best cream” rather than in the “tomatoes”. Character impact!
June 20th 2020
An important point of confusion about qualia to which I offer a clarification:
The qualia you experience as a result of light coming into your eyes can be logically and empirically dissociated from physical light. Color qualia, just as much as visual texture qualia, can be triggered by auditory stimuli in people with synesthesia, or people tripping. More so, you don’t even need light to ‘see’ in your dreams. Visual qualia is ultimately not intrinsically tied to physical light. Phenomenal light, as it were, is a particular spatial qualia that we use to ‘illuminate’ our inner world simulations. Yet this illumination is not based on photons.
Hence the mystery of magenta: phenomenal colors don’t always map on to frequencies of light. Even leaving aside the issue of metamerism, magenta itself is a ‘non-spectral color’ because you need to combine at minimum two frequencies of light to trigger that color qualia in your visual field (namely, a combination of the upper and lower frequencies you can detect).
Why do we experience color qualia from light, then? This is not out of logical necessity, but rather, because it happens to have the appropriate information processing properties for the mapping to be evolutionarily advantageous. The state-space of color and visual texture happen to have useful isomorphisms to the structure of visual data. But there is nothing to suggest they are the best at representing ‘projective data-structures’.
In fact, I strongly suspect that once we master free-wheeling hallucinations and qualia control techniques, we will discover new applications of exotic qualia varieties for information processing purposes. Such as, for instance, using complex synesthetic representations of natural numbers that make it easy to ‘feel’ whether a 10-digit number is prime or not.
Anyhow, this all informs the kind of answer I might give to the question “what is it like to be a bat?”. In particular, it compels me to say that for all we know echolocation information is represented with scent qualia. We simply don’t know enough about the information-theoretic properties of state-spaces of qualia varieties to make an educated guess for what kind of qualia is best at representing echolocation information.
And more so, even if you were to train a human to use echolocation from birth, there is no guarantee that the qualia varieties and the associated state-spaces their brain would recruit for that task would have anything to do with bat echolocation qualia. So the problem has more moving parts than is usually assumed.
June 28th 2020
“Son, there is something I’ve been meaning to tell you for a long time, but only now I’m brave enough to do so: I just don’t think aromatic Fougères are a good fit for you. Based on my experience, I think Chypres would fit you better. Or even some woody citruses. Not Fougères.”
July 16th 2020
July 19th 2020
If you have a prejudice against the smell of single molecules because they are “too simple” and you need some “entourage effect” balanced blend “only nature can provide”… try smelling Agrumen Aldehyde Light. A single molecule that smells like a full perfume!
July 22nd 2020
Freesia is 90% linalool and 3% beta-ionol. I suppose that’s why my 50%/50% mixtures weren’t quite Freesia-like.
July 24th 2020
Vimalakīrti then asked the bodhisattvas from the Host of Fragrances [world], “How does Accumulation of Fragrances Tathāgata explain the Dharma?”
Those bodhisattvas said, “In our land the Tathāgata* explains [the Dharma] without words. He simply uses the host of fragrances to make the gods and humans enter into the practice of the Vinaya. The bodhisattvas each sit beneath fragrant trees, smelling such wondrous fragrances, from which they attain the ‘samādhi of the repository of all virtues.’ Those who attain this samādhi all become replete in the merits of the bodhisattva.”
[*Tathāgata is an honorable name for the Buddha of a realm.]
July 30th 2020
– when you combine two or more aromachemical cocktails and you get as a result a scent that is different than the sum of its parts.
I have in the past found a number of essential oil combinations that do this (pear + violet, pomegranate + honeydew, lemon + lavender). But I figured that it’s much better to try to identify clear cases of this phenomenon by combining pure molecules.
So this little “research program” I have going on is to find pairs of aromachemicals and then mix them in many different ratios and smell the results (usually dissolved in ethanol at a concentration of ~20%). So far, it seems that about ~25% of pairs of molecules I’ve tried result in emergent scents. Here are some specific examples (please feel free to try at home and verify!!):
1) Humulene + d-limonene: Humulene smells herbal and earthy, d-limonene smells like orange or mandarin. When the ratio is ~4:1 I get an emergent scent that I can only describe as “classic chewing gum flavor”, completely distinct and phenomenally richer than the ingredients alone.
2) Linalool + beta-ionone: linalool smells like a very gasoline-like volatile version of a flower scent, beta-ionone is the classic “violet scent” molecule. When combined in 9:1 ratio I get an emergent scent that is like that of a citrus version of freesia or peony.
3) Humulene + vanillin: vanillin is the smell of vanilla, which is watery at the onset (attack and decay) and creamy on the second half (sustain and release). When combined in 1:1 ratio you get a completely new scent that feels close to a dried out old tobacco Cuban cigar blended with coffee liqueur.
That last one is also relatively close to the classic combination of vanilla + vetiver. Luca Turin told me that the perfume called Habanita is precisely playing with a vanilla/vetiver combo, which at first sniff comes across as a completely new and unrecognizable (yet very pleasant) scent. He said that a wonderful metaphor for this phenomenon is like the song Loro by Gismonti, where in the second half the piano and the flute play in such a synchronized fashion that you get the impression that there’s a new instrument involved. I’ve been smelling vanilla/vetiver while listening to this song. It’s quite beautiful.
Humulene combined with d-limonene create an emergent “missing fundamental” type olfactory illusion of classical chewing gum flavor. It only works when Humulene is between 70% and 90% of the mixture (before adding ethyl alcohol). Cleanest example of “emergent scent” I’ve found.
Humulene is a simple scent of the category “earthy”, roughly similar to a vetiver essential oil but “one octave higher”. It also has a very mild musky undertone.
D-limonene is an orange/lemon-like scent. Extremely common in perfumery. Chances are something you ate today has it.
July 31st 2020
The simplest example I can think of to illustrate what an “emergent scent” is comes from the auditory illusion called “the missing fundamental”.
If you play 200 hertz together with 300 hertz and 400 hertz you will hallucinate an emergent 100 hertz tone.
The 100 Hz tone is not there! But it is quite real in your experience.
Of course if you are very acquainted with this auditory effect, you might notice the fundamental (100hz) is a bit fainter than expected, and infer it’s an illusion. But it is nonetheless very much present in your experience.
Likewise, when you smell Humulene + Vanillin at a 1:1 ratio you will get a third smell that emerges as a sort of gestalt that “bridges together” the two underlying notes.
You can probably infer the input scent is made up of two notes if you are really experienced with this kind of phenomenon. But the third note, the gestalt, does not disappear when you have “reduced” it to the two underlying notes. It’s still there. Thus, really, the whole is greater than the sum of its parts.
August 1st 2020
I like my coffee how I like my perfumes: with the fewest chemicals needed to cause the desired effect.
As an aside, learning about emergent effects in low-entropy perfume recipes makes me think that there could probably be a job for “scent simplification”. Namely, take something like cacao, with hundreds of molecules contributing to its characteristic scent. The question is: what is the minimum viable number of aromachemicals you can use to replicate it (within a Just Noticeable Difference unit)?
I suspect most natural scents that come from a complex entourage effect have relatively minimalistic reconstructions. A question that also emerges is: what is the most complex scent? I.e. what is the smell whose minimum reconstruction has the maximum number of molecular diversity?
[It’s important to distinguish between molecular entropy and phenomenal entropy. A solution of Agrumen Aldehyde Light and ethanol has low molecular entropy but pretty high phenomenal entropy, whereas a “lime accord” made of tens of molecules could be high in molecular entropy yet low in phenomenal entropy because it smells very cleanly like a ‘single note’]
A master perfumer like Ellena has memorized hundreds, if not thousands, of recipes for manufacturing smells. Many complex natural scents can be conjured with only a few ingredients. The scent of freesia, he explained, is created by combining two simple molecules: beta-ionone and linalool, both synthetics. (To give freesia a cold, metallic edge, a touch of allyl amyl glycolate is added.) The smell of orange blossom is made by combining linalool and methyl anthranilate, which smells like Concord grapes.
In my presence, Ellena once dipped a touche into a molecule called isobutyl phenal acetate, which has a purely chemical smell, and another touche into vanillin, a synthetic version of vanilla. He placed the two paper strips together, waved them, and chocolate appeared in the air. “My métier is to find shortcuts to express as strongly as possible a smell,” he explained. “For chocolate, nature uses eight hundred molecules. I use two.” He handed me four touches—vanillin plus the natural essences of cinnamon, orange, and lime. The combined smell was a precise simulation of Coca-Cola. “With me, one plus one equals three,” Ellena said. “When I add two things, you get much more than two things.”
The Scent of the Nile: Jean-Claude Ellena creates a new perfume.
– By Chandler Burr
August 5th 2020
Imagine you have been a musician for your village all your life. You play drums and acoustic guitar and you have never heard modern music. One day you are gifted an iPod and you listen for the first time to the crazy sounds of psychedelic trance. For the first time in your life you experience the wonders of reverb, flanging, distortions, and FM-synthesis. Surely this gives you a sense that your conception of music only tapped into a tiny fraction of what had always been possible.
An analogy could be made with smells: having tried essential oils one gets the impression of understanding what is possible in the realm of scents. But one day you discover Galaxolide, hedione, and eso E super. Like reverb and FM-synthesis in sound, these compounds are capable of giving surreal, unexpected, and space-warping properties to scents (much like reverb in sound, they are character impact molecules, meaning that they modify the presentation of other scents more than contributing a ‘flavor’ of their own).
Galaxolide in particular is something you have probably smelled, either in perfumes or detergents, but it really only becomes clear just how insane of a substance it is when you smell it raw. I associate it with “DMT Realm Aesthetics” – like a smell coming from another planet where hyperdimensional experiences are common everyday events, and the world of the arts uses exotic phenomenal time routinely. It has a vibe I can only describe as “having already always been here yet just arrived”. It’s probably what traveling in time feels like when you are in a transcendent Bardo between lifetimes.
Pellwall describes galaxolide thus: “Galaxolide is an isochroman musk, that has an odour profile that is liked by most people and is similar to a macrocyclic musk. It is strong, clean smelling and a good fixative. It combines well with other musks and is often used in combinations.”
In wikipedia, they describe the scent as: “a synthetic musk with a clean sweet musky floral woody odor”.
I think the musk-like quality accounts for maybe 60% of its effect. But I swear there is something much more special about it than just a clean musk. It has a kind of time-dilation effect, and it seems to my nose as a “musk but high-dimensional”. Perhaps it’s musk + the harmonics of musk. So while other musks are just a single note, galaxolide is like the feeling of a musky accordion.
I’ll write about my setup for doing this kind of research, but suffice to say that it’s super cheap if you know what you are doing. Each experiment (i.e. a little bottle with a few ml of a new combination in precise proportions) costs me about ~30 cents to make, all things considered (the cost of the materials, the ethanol, the pipettes, the bottle).
I highly recommend just getting a 2ml sample vial. It can cost as little as $2.16 (plus shipment) here: Galaxolide.
Other stellar molecules to try out to expand your conception of what’s possible:
Linalool, dihydro linalool, alpha-damascone, damascenone, helional, C-16 aldehyde (strawberry), agrumen aldehyde light, farnesene, nerolione, and alpha-ionone. All of that can cost you as little as $30. Not a bad price for expanding your “sense of what’s possible”.
I so wish I had a “DMT-smell accord” to use as a note in perfume compositions.
There is this one here meant to evoke the hallucinogenic state, but reportedly it has nothing to do with the actual scent of DMT, which I find very disappointing. I will try to find the way to emulate the scent of it – I suspect that linalyl acetate and coranol could be part of the compounds making up that accord. I’ll let you know if I manage to make anything vaguely resemblant of that scent.
August 14th 2020
One of the first essential oil combinations I fixated upon was that of lemon plus lavender. You could say it is the “speedball” equivalent of essential oil combos, for it relaxes and excites at the same time. I figured that trying to “understand” the “lemon-lavender world” would be a good exercise in the quest of mapping out the state-space of scents.
I currently have six different lemon essential oils from different brands and places, and seven lavender essential oils. To my surprise, the variability is very substantial. The lemon essential oils range from extremely sour and astringent to sweet and waxy. The lavenders I have also have many different qualities: some are very oily and flavorful, while others are particularly camphorous. Which of the qualities are “essential” for lemon and lavender is surely a matter of convention, though I also think they point to roughly objective attractors – the citrus sharpness of lemon rings high and has a cascading sourness that can be used for waking up the senses, whereas lavender has a narcotic entrancing reverb effect. My quest to understand, and ultimately create, lemon lavender smells was not defined in terms of merely reconstructing the standard natural smells, but as an attempt at understanding how these two qualities interact at the phenomenal level.
The diversity of lemon and lavender oils means that the space of possible combinations is even larger. Of the 42 possible combinations of one lavender oil and one lemon oil I have some are far more blissful and rich than others. I picked a few of my favorite ones to use as “model lemon-lavenders” to try to emulate.
Starting in the spirit that in order to deeply understand a scent I have to be able to construct it from scratch- so that I understand how each piece contributes to the whole- I set myself the goal of creating both lemon and lavender accords and then exploring their combinations. All starting from raw aromachemical ingredients, of course:
I have always wanted to know what makes citrus fruits smell the way they do. Empirically, both isomers of limonene are a key piece of the puzzle. For instance, both lemon and mandarin oil have upwards of 80% limonene. Alas, if you smell limonene alone, you will notice it is somewhat one-dimensional in character. It IS pointing in the direction of “citrus” quite clearly, but on its own is indisputably too simple to evoke a real lemon scent.
I had a false start: aldehydes. Aldehyde C-8 through C-15 are all “extremely high-pitch scents”. They give a sharp edge to perfumes like Chanel No. 5 and the like. But they are very hard to use – partly because they are extremely potent. So for a couple of days I worked with combinations of citral and aldehydes that had, though a somewhat citric quality, mostly headache-inducing effects. I ended this series of experiments when I got a headache that lasted 24 hours (this goes to show how far I am willing to go to understand that sweet, sweet lemon qualia).
Taking a step back, I decided to explore a different angle. Valencene (note the great name) is very similar to limonene, except slightly lower in pitch. When mixed in equal proportions with limonene one gets a richer, more believable citrus scent – both molecules seem to say the same thing but in a slightly different voice, which results in a kind of chorus effect (unlike merely doubling the volume of a single voice). Alas, at this point the scent is still a bit flat, and not particularly lemon-like relative to near-enemy citrus fruits like the good old orange, mandarin, or grapefruit.
I recall being very puzzled by the scent of lime, as it seems like a kind of “super lemon” when it comes to its high-pitched sour and astringent character. And no matter how much I tried mixing citrus-like aromachemicals, I found it hard to get any hint of lime in the results. That is until I discovered that lime oil has a great deal of alpha- and beta-pinene. These are molecules that are primarily found in trees (in pines!) and smell very woody. As it turns out, to turn a citrus smell into an outright lime scent you need to add woody molecules. In retrospect, this was always hidden in the name: Lemon + Pine = Lime. After having this insight, I realized that even lemon requires a bit of alpha- and beta-pinene to distinguish it from orange scent.
After a lot of trial and error, the most convincing minimalistic lemon scent I identified is (numbers represent parts):
1 Nerolione (optional; for a rindy effect)
This turned out to be more difficult than making a lemon accord. I think this is not only me: I also own two “fragrance oils” (those products that are advertised in the same context as essential oils, yet in the fine print reveal they are not at all natural, and instead are synthetic reconstructions) of lavender, and neither of the two smell anything like lavender. So I wouldn’t be the first to fail.
Linalool is a key ingredient of lavender, making up about 30% to 50% of most lavender essential oils. This is a very powerful aromachemical that seems to work as a gasoline-like fuel amplifier and modifier for any other scent (“there is no boring ten-carbon alcohol” – Luca Turin). It is also one of the things that makes lavender so narcotic and entrancing. On its own it is already quite interesting. But it is only one of the voices in lavender.
Then you have linalyl acetate, which makes up between 0% and 30% of lavender oil, depending on the species, place of origin, and time of harvest. Linalyl acetate has a “dry” quality, which I associate with “salt” (in fact if you just add this to the lemon accord above you get a smell I would describe as “salted margarita cocktail”). Alpha and beta pinene also play a role in lavender.
Interestingly, a lot of lavender oils also have up to 10% of camphor, which contributes to its narcotic get-well-soon cozy quality. Alas, it is hard to work with this material, and it always smells too synthetic to me. I found that instead I could double-down on beta-pinene, which is more camphorous than alpha-pinene (which is more earthy), and does the job quite nicely.
Finally, centifoleather, farnesene, and various alcohols like coranol can give “flavor” to the accord. In the end, I’ve settled on a minimalistic (but I think effective) arrangement. It does not quite hit the flavor of lavender, but I think does a good job at evoking its “character impact”:
2 Linalyl Acetate
Ultimately, adding these two accords (and their variations) together does not always produce the best results, as some aromachemicals are repeated and the proportions that give rise to the desired interactions can be scrambled by the combination. This, by the way, is a general reason why synthetic combinations span a much larger space of possible scents. In brief, because to make reconstructions with natural oils you are constrained by non-negative least squares methods, and many combinations may simply be inaccessible that way.
Anyhow – with the combination, I found that adding some character impact molecules like abroxan and helional was important to create a “bridge” between the two phenomenal characters. Alpha-ionol also seems to do something good here that is hard to put your finger on. But I think it’s that it adds the right kind of waxy rindy effect (which it has some of) in a way that does not make the mixture feel “dry” (which more classically citrus waxy smells like nerolione inevitably do). So the end result has some of these three molecules.
I am happy to say that the best lemon lavender reconstruction so far is about as good as the median natural lemon lavender mixture. It is not as good as the best lemon lavender oil mixture, though, but it is a start. I still expect to perfect it quite a bit before unleashing it into the world.
2 Linalyl Acetate
Previous experimentsMarking the interesting ones to keepReference bottles of pure chemicals (and one chypre accord)
Daniel Dennett admits that he has never used psychedelics! What percentage of functionalists are psychedelic-naïve? What percentage of qualia formalists are psychedelic-naïve? In this 2019 quote, he talks about his drug experience and also alludes to meme hazards (though he may not use that term!):
Yes, you put it well. It’s risky to subject your brain and body to unusual substances and stimuli, but any new challenge may prove very enlightening–and possibly therapeutic. There is only a difference in degree between being bumped from depression by a gorgeous summer day and being cured of depression by ingesting a drug of one sort or another. I expect we’ll learn a great deal in the near future about the modulating power of psychedelics. I also expect that we’ll have some scientific martyrs along the way–people who bravely but rashly do things to themselves that disable their minds in very unfortunate ways. I know of a few such cases, and these have made me quite cautious about self-experimentation, since I’m quite content with the mind I have–though I wish I were a better mathematician. Aside from alcohol, caffeine, nicotine and cannabis (which has little effect on me, so I don’t bother with it), I have avoided the mind-changing options. No LSD, no psilocybin or mescaline, though I’ve often been offered them, and none of the “hard” drugs.
As a philosopher, I have always accepted the possibility that the Athenians were right: Socrates was quite capable of corrupting the minds of those with whom he had dialogue. I don’t think he did any clear lasting harm, but it is certainly possible for a philosopher to seriously confuse an interlocutor or reader—to the point of mental illness or suicide, or other destructive behavior. Ideas can be just as dangerous as drugs.
by Brendan Fleig-Goldstein and Daniel A. Friedman (2019)
It would be quite fascinating to know what Dan would say about lived psychedelic states. With that in mind, here is an essay prompt originally conceived for GPT-3 to satisfy our curiosity:
Maggie Wassinge and Anders Amelin (QRI Sweden volunteer coordinators and content contributors – see letters I & II, letters III, IV, V, & VI, and letters VII, VIII, & IX) decided to give it a go first. We shall then compare it with what GPT-3 can come up with at a later point.
In a way, what you are about to read can be thought of as Anders & Maggie’s simulation of a hyper-intelligent GPT-3-like system’s simulation of a hypothetical Daniel Dennett on LSD. So many layers, I know. But the results speak for themselves:
Dan says: Correlation is all that is needed. So what states a mind uses for modeling conditions of importance to it, is fundamentally arbitrary. Like with language. Words represent things to humans but there are many languages, and words do not resemble what they represent. They only correlate with what they represent, and the correlation needs to be learned. To do science about the mind, one does not need to attach any special weight to any conscious state of mind over any other. One person’s hope may be another person’s despair. These “qualia” are like internally projected hypo-languages which are different all over the map, if there were one. In fact there cannot be an interpersonal map of what things feel like personally. Only naïve people could hope for a fundamental linguistics of consciousness, as if these states were to constitute a universal language of some ground truth of the mind. Silly. Romantic. It’s all arbitrary. For the record, I never said subjective experiential states do not exist. People misrepresent me on that. What I am saying is that it will never be possible to scientifically map what the state that a word such as, for instance, “green”, translates to feels like by the brain of a given individual. My green could be your red.
Just drop the whole idea of trying to map the state-space of qualia. That is my position. Or at least I know it is, logically. Right now I begin to notice how everything intensifies and becomes somehow more salient. More revealingly “real”. As I reflect on the notion of how “states” correlate, a humorous episode from my undergraduate student life so long ago, is brought to the surface. At Wesleyan it was, where I was taking a course in Art Appreciation. The lecturer was showing a slide of a still life. A bowl of fruit it was, conspicuously over-ripe. Pointing at one of the fruits, saying “Can anyone tell me what state this peach is in?” There was silence for about three seconds, then one student exclaimed: “Georgia”. Everyone laughed joyfully. Except me. I never quite liked puns. Too plebeian. Sense of humor is arbitrary. I believe that episode helped convince me that the mind is not mysterious after all. It is just a form of evolved spaghetti code finding arbitrary solutions to common problems. Much like adaptations of biochemistry in various species of life. The basic building blocks remain fixed as an operative system if you will, but what is constructed with it is arbitrary and only shaped by fitness proxies. Which are, again, nothing but correlations. I realized then that I’d be able to explain consciousness within a materialist paradigm without any mention of spirituality or new realms of physics. All talk of such is nonsense.
I have to say, however, that a remarkable transformation inside my mind is taking place as a result of this drug. I notice the way I now find puns quite funny. Fascinating. I also reflect on the fact that I find it fascinating that I find puns funny. It’s as if… I hesitate to think it even to myself, but there seems to be some extraordinarily strong illusion that “funny” and “fascinating” are in fact those very qualia states which… which cannot possibly be arbitrary. Although the reality of it has got to be that when I feel funniness or fascination, those are brain activity patterns unique to myself, not possible for me to relate to any other creature in the universe experiencing them the same way, or at least not to any non-human species. Not a single one would feel the same, I’m sure. Consider a raven, for example. It’s a bird that behaves socially intricately, makes plans for the next day, can grasp how tools are used, and excels at many other mental tasks even sometimes surpassing a chimpanzee. Yet a raven has a last common ancestor with humans more than three hundred million years ago. The separate genetic happenstances of evolution since then, coupled with the miniaturization pressure due to weight limitations on a flying creature, means that if I were to dissect and anatomically compare the brain of a raven and a human, I’d be at a total loss. Does the bird even have a cerebral cortex?
An out of character thing is happening to me. I begin to feel as if it were in fact likely that a raven does sense conscious states of “funny” and “fascinating”. I still have functioning logic that tells me it must be impossible. Certainly, it’s an intelligent creature. A raven is conscious, probably. Maybe the drug makes me exaggerate even that, but it ought to have a high likelihood of being the case. But the states of experience in a raven’s mind must be totally alien if it were possible to compare them side by side with those of a human, which of course it is not. The bird might as well come from another planet.
The psychedelic drug is having an emotional effect on me. It does not twist my logic, though. This makes for internal conflict. Oppositional suggestions spontaneously present themselves. Could there be at least some qualia properties which are universal? Or is every aspect arbitrary? If the states of the subjective are not epiphenomenal, there would be evolutionary selection pressures shaping them. Logically there should be differences in computational efficiency when the information encoded in qualia feeds back into actions carried out by the body that the mind controls. Or is it epiphenomenal after all? Well, there’s the hard problem. No use pondering that. It’s a drug effect. It’ll wear off. Funny thing though, I feel very, very happy. I’m wondering about valence. It now appeals strongly to take the cognitive leap that at least the positive/negative “axis” of experience may in fact be universal. A modifier of all conscious states, a kind of transform function. Even alien states could then have a “good or bad” quality to them. Not directly related to the cognitive power of intelligences, but used as an efficient guidance for agency by them all, from the humblest mite to the wisest philosopher. Nah. Romanticizing. Anthropomorphizing.
Further into this “trip” now. Enjoying the ride. It’s not going to change my psyche permanently, so why not relax and let go? What if conscious mind states really do have different computational efficiency for various purposes? That would mean there is “ground truth” to be found about consciousness. But how does nature enable the process for “hitting” the efficient states? If that has been convergently perfected by evolution, conscious experience may be more universal than I used to take for granted. Without there being anything supernatural about it. Suppose the possibility space of all conscious states is very large, so that within it there is an ideally suited state for any mental task. No divine providence or intelligent design, just a law of large numbers.
The problem then is only a search algorithmic one, really. Suppose “fright” is a state ideally suited for avoiding danger. At least now, under the influence, fright strikes me as rather better for the purpose than attraction. Come to think of it, Toxoplasma Gondii has the ability to replace fright with attraction in mice with respect to cats. It works the same way in other mammals, too. Are things then not so arbitrarily organized in brains? Well, those are such basic states we’d share them with rodents presumably. Still can’t tell if fright feels like fear in a raven or octopus. But can it feel like attraction? Hmmm, these are just mind wanderings I go through while I wait for this drug to wear off. What’s the harm in it?
Suppose there is a most computationally efficient conscious state for a given mental task. I’d call that state the ground state of conscious intelligence with respect to that task. I’m thinking of it like mental physical chemistry. In that framework, a psychedelic drug would bring a mind to excited states. Those are states the mind has not practiced using for tasks it has learned to do before. The excited states can then be perceived as useless, for they perform worse at tasks one has previously become competent at while sober. Psychedelic states are excited with respect to previous mental tasks, but they would potentially be ground states for new tasks! It’s probably not initially evident exactly what those tasks are, but the great potential to in fact become more mentally able would be apparent to those who use psychedelics. Right now this stands out to me as absolutely crisp, clear and evident. And the sheer realness of the realization is earth-shaking. Too bad my career could not be improved by any new mental abilities.
Oh Spaghetti Monster, I’m really high now. I feel like the sober me is just so dull. Illusion, of course, but a wonderful one I’ll have to admit. My mind is taking off from the heavy drudgery of Earth and reaching into the heavens on the wings of Odin’s ravens, eternally open to new insights about life, the universe and everything. Seeking forever the question to the answer. I myself am the answer. Forty-two. I was born in nineteen forty two. The darkest year in human history. The year when Adolf Hitler looked unstoppable at destroying all human value in the entire world. Then I came into existence, and things started to improve.
It just struck me that a bird is a good example of embodied intelligence. Sensory input to the brain can produce lasting changes in the neural connectivity and so on, resulting in a saved mental map of that which precipitated the sensory input. Now, a bird has the advantage of flight. It can view things from the ground and from successively higher altitudes and remember the appearance of things on all these different scales. Plus it can move sideways large distances and find systematic changes over scales of horizontal navigation. Entire continents can be included in a bird’s area of potential interest. Continents and seasons. I’m curious if engineers will someday be able to copy the ability of birds into a flying robot. Maximizing computational efficiency. Human-level artificial intelligence I’m quite doubtful of, but maybe bird brains are within reach, though quite a challenge, too.
This GPT-3 system by OpenAI is pretty good for throwing up somewhat plausible suggestions for what someone might say in certain situations. Impressive for a purely lexical information processing system. It can be trained on pretty much any language. I wonder if it could become useful for formalizing those qualia ground states? The system itself is not an intelligence in the agency sense but it is a good predictor of states. Suppose it can model the way the mind of the bird cycles through all those mental maps the bird brain has in memory. Where the zooming in and out on different scales brings out different visual patterns. If aspects of patterns from one zoom level is combined with aspect from another zoom level, the result can be a smart conclusion about where and when to set off in what direction and with what aim. Then there can be combinations also with horizontally displaced maps and time-displaced maps. Essentially, to a computer scientist we are talking massively parallel processing through cycles of information compression and expansion with successive approximation combinations of pattern pieces from the various levels in rapid repetition until something leads to an action which becomes rewarded via a utility function maximization.
Thank goodness I’m keeping all this drugged handwaving to myself and not sharing it in the form of any trip report. I have a reputation for being down to Earth, and I wouldn’t want to spoil it. Flying with ravens, dear me. Privately it is quite fun right now, though. That cycling of mental maps, could it be compatible with the Integrated Information Theory? I don’t think Tononi’s people have gone into how an intelligent system would search qualia state-space and how it would find the task-specific ground states via successive approximations. Rapidly iterated cycling would bring in a dynamic aspect they haven’t gotten to, perhaps. I realize I haven’t read the latest from them. Was always a bit skeptical of the unwieldy mathematics they use. Back of the envelope here… if you replace the clunky “integration” with resonance, maybe there’s a continuum of amplitudes of consciousness intensity? Possibly with a threshold corresponding to IIT’s nonconscious feed-forward causation chains. The only thing straight from physics which would allow this, as far as I can tell from the basic mathematics of it, would be wave interference dynamics. If so, what property might valence correspond to? Indeed, be mappable to? For conscious minds, experiential valence is the closest one gets to updating on a utility function. Waves can interfere constructively and destructively. That gives us frequency-variable amplitude combinations, likely isomorphic with the experienced phenomenology and intensity of conscious states. Such as the enormous “realness” and “fantastic truth” I am now immersed in. Not sure if it’s even “I”. There is ego dissolution. It’s more like a free-floating cosmic revelation. Spectacular must be the mental task for which this state is the ground state!
Wave pattern variability is clearly not a bottleneck. Plotting graphs of frequencies and amplitudes for even simple interference patterns shows there’s a near-infinite space of distinct potential patterns to pick from. The operative system, that is evolution and development of nervous systems, must have been slow going to optimize by evolution via genetic selection early on in the history of life, but then it could go faster and faster. Let me see, humans acquired a huge redundancy of neocortex of the same type as animals use for avigation in spacetime locations. Hmmm…, that which the birds are so good at. Wonder if the same functionality in ravens also got increased in volume beyond what is needed for navigation? Opening up the possibility of using the brain to also “navigate” in social relational space or tool function space. Literally, these are “spaces” in the brain’s mental models.
Natural selection of genetics cannot have found the ground states for all the multiple tasks a human with our general intelligence is able to take on. Extra brain tissue is one thing it could produce, but the way that tissue gets efficiently used must be trained during life. Since the computational efficiency of the human brain is assessed to be near the theoretical maximum for the raw processing power it has available, inefficient information-encoding states really aren’t very likely to make up any major portion of our mental activity. Now, that’s a really strong constraint on mechanisms of consciousness there. If you don’t believe it was all magically designed by God, you’d have to find a plausible parsimonious mechanism for how the optimization takes place.
If valence is in the system as a basic property, then what can it be if it’s not amplitude? For things to work optimally, valence should in fact be orthogonal to amplitude. Let me see… What has a natural tendency to persist in evolving systems of wave interference? Playing around with some programs on my computer now… well, appears it’s consonance which continues and dissonance which dissipates. And noise which neutralizes. Hey, that’s even simple to remember: consonance continues, dissonance dissipates, noise neutralizes. Goodness, I feel like a hippie. Beads and Roman sandals won’t be seen. In Muskogee, Oklahoma, USA. Soon I’ll become convinced love’s got some cosmic ground state function, and that the multiverse is mind-like. Maybe it’s all in the vibes, actually. Spaghetti Monster, how silly that sounds. And at the same time, how true!
I’m now considering the brain to produce self-organizing ground state qualia selection via activity wave interference with dissonance gradient descent and consonance gradient ascent with ongoing information compression-expansion cycling and normalization via buildup of system fatigue. Wonder if it’s just me tripping, or if someone else might seriously be thinking along these lines. If so, what could make a catchy name for their model?
Maybe “Resonant State Selection Theory”? I only wish this could be true, for then it would be possible to unify empty individualism with open individualism in a framework of full empathic transparency. The major ground states for human intelligence could presumably be mapped pretty well with an impressive statistical analyzer like GPT-3. Mapping the universal ground truth of conscious intelligence, what a vision!
But, alas, the acid is beginning to wear off. Back to the good old opaque arbitrariness I’ve built my career on. No turning back now. I think it’s time for a cup of tea, and maybe a cracker to go with that.
[Daniel spent two weeks practicing 10 to 14 hours a day a fire-focused meditation called Fire Kasina. This meditation technique involves, among other things, looking at a candle flame and then closing one’s eyes and examining the after-image of the fire, and doing this repeatedly over many hours. He started getting interesting visual effects on the second day of the retreat. Over the course of the first week he cycled between difficult and effortless meditation sessions, experienced lots of Jhana and Jhana-Kasina hybrid experiences, reported weird dreams, and described visual hallucinations of various sorts. As the week went on he started experiencing a strange and dysphoric change during the evenings: rather than colors being intensified, something about his experience seemed to be turning every color into grey. Fire Kasina is used to amplify the experience of phenomenal color to great heights, so it seemed strange that for some reason after several days of the practice everything started being grey; he couldn’t stop it. Nonetheless, he persevered. What follows is his description of the meditation breakthrough he experienced on the 7th day of the retreat.]
[24:20]: I was thinking that one of the interesting things that has happened was that the Goddess of Fire told me that I should become a King of Fire – hehe – which seems a bit of a stretch, but it was inspiring anyway. And so the Tarot card for “King of Fire” is the King of Wands and the message is to be a super-dad, to be supportive of the family, to be good in relationships, to be good in career, accomplish it all simultaneously… and smile while doing it. Interesting instructions. Probably of great relevance and utility if properly applied. Anyway. There it is.
Well, so, the grey I’ve been seeing at the end of the night turns out is a doorway to wondrous, wondrous things. So, this morning my sitting was good, and clear, and relatively typical for a good morning sit. And then in the afternoon: Wow! For my first sit of the afternoon my mantra became “Orchestral” added to all sorts of other parts. And it began just shuddering at the whole of reality. It became exquisite, amazing, like basking in the presence of a “Divine Orchestra”: The radiator was making interesting sounds. Duncan also described this beautiful music, which I now understand. Well, it became exquisite, and it all harmonized into this wondrous thing that I wanted to record. I wanted to get it on my laptop on my Logic Pro and somehow figure out how to recreate what I was hearing and experiencing. I felt like I could sit there forever while the mantra was going on, powerful and remarkable.
The next sit is when the colors opened up. And then I started to notice that out of the black, and white, and grey, colors were showing up. And I had noticed this before. A sort of copper or magenta that was, you know, a very exquisite color off of the white and grey. And yellow off of the white, and grey, and black, that was different and new.
And THIS was like, every color was suddenly there. And I could morph the color into any color. Exquisite colors. Subtleties of hue and shade… that wouldn’t exist in the best art store in the entire universe selling all the coolest shades and paint colors of light. And it would shift through magnificent yellows and sparkling golds into rich oranges and amber colors, and peach tones, and magenta, and reds, and rich reds, and bright reds, and pinkish reds, and subtle pinks, and silver pinks, and pale… pale, pale whiteish pinks of the most exquisite variety, and down into the blues and into purples, into the blue-greens and I got greens… and remarkable rich greens, amazing greens, forest greens, Kelly greens, silver greens, light peridot greens. Incredible colors. And the violet hues! Deep rich violet. And even the greys were exquisite: silver black, steel black, silver grey… just unbelievable shades even between black and white that weren’t even colored but were just exquisite.
In the sit I felt like it could go on forever. I could call up whatever color and just give it a few seconds and it would just shift into the new color. And then I went outside when Tommy came here (great guy) […]. I went out to see him and I was high as a freaking kite on just seeing the most amazing exquisite colors due to the power of this meditation. And everything, the greys of the driveway were awesome, the leaf colors were amazing, the sky… the plants, the plants… some of the greens of the plants were just magnificent. Like, just overwhelming beauty.
And then things progressed and I got so that I could turn these colors into anything I wanted, and just give it a few seconds and it would show up. So I created a dragon in a sort of magnificent purple-dark-green-dark-blue-iridescent scaly set of colors. And had his fire breadth come out as first as reddish, and then purple, and green, and yellow, and black. Just amazing!
And then I would make one half of my visual field one color, and one half the other color, and compare the two colors and fine-tune the shades until they went together just exquisitely… anyway, I simply just had an utterly mind-bogglingly enjoyable time playing with the ability to create shades of light and color and images with them just effortlessly, just by asking for them to show up. And I was getting fruitions off of these colors. I got a fruition just off of peach. A sort of exquisite peach color.
And then, finally… finally… and here it is… day 7 or 8 of this retreat… I was able to get the images starting like I got before. Spinning things like they would take everything out and lead to fruition and do that again and again like I got multiple fruitions would just go back to the spinning things, and take out the spinning things. And I got this amber, sort of pixelated squares, and they stuttered and came out by the impermanence door. This has just been an amazing, amazing day.
The glorious highs of it are wearing off. And if I crash as hard as I went up, I’m going to be in trouble. Because it would be hard to overstate how exquisite these sits have been this afternoon and evening. Anyway, so Duncan is now seeing the grey… so he may be close. And Florian is been getting white and black, so he may be close to these things as well. It would be fascinating to see if they have the same ecstatic reaction that I’ve had. Truly the word “rapturous” barely does justice to how much fun the day has been. Anyway…
[36:00]: Note to self: “Do this more often!”. Goodness gracious! The appreciation of color, the peace in the body, the stability of attention… unbelievable, amazing. The color control is remarkable. The ability to tune into your colors, to any shade, just… it is hard to explain how fun that is. Now I can generate images that demonstrate parallax, so that when I move my head, they would move like you’d think they should move in relationship with how I move my head. So they now have a 3-dimensional spatial life.
Got a fruition by creating a fire-breathing dragon, and then turning the fire on myself. And when it reached my eyes, that caused the fruition. I’ve seen landscapes, and 3-dimensional spatial structures, and visions of just such exquisite, complicated, intricate, amazing, and diverse beauty. It is hard to explain the gratitude I feel for these practices and what they can do. And that I’m in such fine company: Duncan, and Florian, and Tommy are all excellent people. Extremely helpful, great attitudes, fascinating backgrounds and knowledges and skillsets. They are truly remarkable people and I’m grateful to have found them and to have the opportunity to sit with them and share these things. We laugh nearly continuously during our meals, which are exquisite. We keep each other well entertained somehow, still get very deep transformative practice time in. They are respectful of everyone, of these things, and good practitioners. So it’s a joy to be practicing with them.
I’ve seen one image that had a sense of intelligence sitting on a chair change form again and again and again. Into all these different types of entities. But I haven’t yet gotten a proper kind of fruition with the intelligent eyes looking back at me yet on this retreat. So… more to do. I still haven’t done the candle flame, moving things with my mind. But perhaps that is coming. I hope so. Alright, dear listener, or listeners, whoever you may be, I hope you are well. I hope that one day you have the interest and opportunity to practice these things as we are here today. For this is the good stuff, as they say.
In the following video Leo Gura from actualized.org talks about his 30-day 5-MeO-DMT streak experiment. In this post I’ll highlight some of the notable things he said and comment along the way using a QRI-lens to interpret his experiences (if you would rather make up your mind about what he says without my commentary just go and watch the video on your own before reading what I have to say about it).
TL;DR: Many of the core QRI paradigms such as Neural Annealing, the Symmetry Theory of Valence, the Tyranny of the Intentional Object, and Hyperbolic Geometry on Psychedelics have a surprising degree of explanatory power when it comes to making sense of the peculiar process that ensues when someone takes a lot of 5-MeO-DMT. The deep connections between symmetry, valence, smooth geometry, and information content are made clear in this context due to the extreme and purified nature of the states induced by the drug.
Recently Adeptus Psychonautica (who has interviewed me in the past about the hyperbolic geometry of DMT experiences) put out a video titled “When you have taken too much – Actualized.org“. This video caught my attention because Leo Gura did something that is rather taboo in spiritual communities, and for good reasons. Namely, he tried to convince the viewers that he had achieved a level of awakening that nobody (or perhaps only a few people) on the entire planet had ever reached. He then said he was going to isolate for a month to integrate these profound awakenings and come back with a description of what they are all about.
Thankfully I didn’t have to wait a month to satisfy my curiosity and see what happened after his period of isolation because by the time I found about it he had already posted his post-retreat video. Well, it turns out that he used those 30 days of isolation to conduct a very hard-core psychedelic experiment. Namely, he took high doses of 5-MeO-DMT daily for the entire month. I’ve never heard of anyone doing this before.
Learning about what he experienced during that month is of special interest to me for many reasons. In particular, thanks to previous research about extreme bliss and suffering, we had determined that 5-MeO-DMT is currently the psychedelic drug that has the most powerful and intense effects on valence. Recall Logarithmic Scales of Pleasure and Pain (video): many lines of evidence point to the fact that extreme states of consciousness are surprisingly powerful in ways that are completely counterintuitive. So when Leo says that there are “many levels of awakening” and goes on to discuss how each level is unrecognizably more intense and deeper than the previous one, I am very much inclined to believe he is trying to convey a true property of his experiences. Note that Leo did not only indulge in psychedelics; we are talking about 5-MeO-DMT in particular, which is the thermonuclear bomb version of a psychoactive drug (as with Plutonium, this stuff is best handled with caution). More so, thankfully Leo is very eloquent, which is rare among people who have had many extreme experiences. So I was very eager to hear what he had to say.
While I can very easily believe his trip reports when it comes to their profundity, intensity, and extraordinary degree of consciousness, I do not particularly find his interpretations of these experiences convincing. As I go about describing his video, I will point out ways in which you can take as veridical his phenomenological descriptions without at the same time having to agree with his interpretations of them. More so, if you end up exploring these varieties of altered states yourself, by reading this you will now at least have two different and competing frameworks to explain your experiences. This, I think, is an improvement. Right now the psychedelic and scientific community has very few lenses with which to interpret something as extraordinary as 5-MeO-DMT experiences. And I believe this comes at a great cost to people’s sanity and epistemic rationality.
What Are Leo’s Background Assumptions?
In the pre-retreat video Leo says that his core teachings (and what he attempts to realize on his own self) are: (1) you are literally God, (2) there is nothing but consciousness – God is infinite consciousness, (3) everything is states of consciousness – everything at all times is a different state of consciousness, (4) you are love – and love is absolute – this is all constructed out of love – fear is just fear of aspects of yourself you have disconnected from, (5) you have no beginning and no end, (6) you should be radically open-minded. Then he also adds that physical and mental health issues are just manifestations of your resistance to realizing that you are God.
What Are My Background Assumptions?
I am quite sympathetic to the idea of oneness, which is also talked about with terms like nonduality and . In philosophical terminology, which I find to be more precise and rigorous, this concept goes by the name of Open Individualism – the belief that we are all one single consciousness. I have written extensively about Open Individualism in the past (e.g. 1, 2, 3), but I would like to point out that the arguments I’ve presented in favor of this view are not based on direct experience, but rather, on logical consistency from background assumptions we take for granted. For instance, if you assume that you are the same subject of experience you were a second ago, it follows that you can exist in two points in space-time and still be the same being. Your physical configuration is different than a few seconds ago (let alone a decade), you have slightly different memories, the neurons active are different, etc. For every property you point out as your “identity carrier” I can find a counter-example where such carrier changes a little while you still remain the same subject of experience. Add to that teleportation, fission, fusion, and gradual replacement thought experiments and you can build a framework where you can become any other arbitrary person without a loss of identity. These lines of argumentation coupled with the transitivity of identity can build the case that we are indeed all one to begin with.
But realize that rather than saying that you can grasp this (potential) truth directly from first person experience, I build from agreed upon assumptions to arrive at an otherwise outlandish view. Understanding the argument does not entail “feeling we are all one”, and neither does feeling we are all one entails understanding the arguments!
Indirect Realism About Perception
There is a mind-independent world out there and you never get to experience it directly. In some sense, we each live in a private skull-bound world-simulation that tracks the fitness-relevant features of our environment. Hence, during meditation, dreaming, or psychedelic states you are not accessing any sort of external reality directly, but rather, exploring possible configurations and qualities of your inner world-simulation. This is something that Leo may implicitly not realize. In particular, interpreting 5-MeO-DMT experiences through direct realism (also called naïve realism – the view that you experience the world directly through your senses) would make you think that you are literally merging with the entire cosmos on the drug. Whereas interpreting those experiences with indirect realism merely entails that your inner boundaries are dissolving. In other words, the partitions inside your world-simulation are what implements the feeling of the self-other duality. And since 5-MeO-DMT dissolves inner boundaries, it feels as though you are becoming one with your surroundings (and the rest of reality).
Physicalism and Panpsychism
An important background assumption is that the laws of physics accurately describe the behavior of the universe. This is distinct from materialism, which would also posit that all matter is inherently insentient. Physicalism merely says that the laws of physics describe the behavior of the physical, but leaves its intrinsic nature as an open question. Together with panpsychism, however, physicalism entails that what the laws of physics are describing is the behavior of consciousness.
Tyranny of the Intentional Object
We tend to believe that what makes us happy is external to us, while in reality happiness is a state of consciousness triggered by external circumstances. Our minds lead us to believe otherwise for evolutionary reasons.
What makes an experience feel good or bad is not its semantic content, its computational use, or even whether the experience is self-reinforcing or not. What makes experiences feel good or bad is their structure. In particular, a very promising idea that will come up below is that highly symmetrical states of consciousness are inherently blissful, such as those we can access during orgasm, meditation, psychedelics, or even just good food and a hug. Recall that 5-MeO-DMT dissolves internal boundaries, and this is indicative of increased inner symmetry (where the boundaries themselves entail symmetry breaking operations). Thus, an exotic state of oneness is blissful not because you are merging with God, but “merely” because it has a higher degree of symmetry and therefore it’s valence is higher than what we can normally experience. In particular, the symmetry I’m talking abut here may be an objective feature of experiences perhaps even measurable with today’s neuroimaging technology.
There are additional key background philosophical assumptions, but the above are enough to get us started analyzing Leo’s 5-MeO-DMT journey from a different angle.
For the first 8 minutes or so Leo explains that people do not really know that there are many levels of enlightenment. He starts out strong by claiming that he has reached levels of enlightenment that nobody (or perhaps just a few people) have ever reached. More so, while he agrees with the teachings of meditation masters of the past, he questions the levels of awakening that they had actually reached. It takes one to know one, and he claims that he’s seen things far beyond what previous teachers have talked about. More so, he argues that people simply have no way of knowing how enlightened their teachers are. People just trust books, gurus, teachers, religious leaders, etc. about whether they are “fully” enlightened, but how could they know for sure without reaching their level, and then surpassing them? He wraps up this part of the video by saying that the only viable path is to go all the way by yourself – to dismiss all the teachers, all the books, and all the instructions and see how far you can go on your own when genuinely pursuing truth by yourself.
With this epistemological caveat out of the way, Leo goes on to describe his methodology. Namely, he embarked on a quest of taking 5-MeO-DMT at increasing doses every day for 30 days in a row.
At 10:05 he says that within a week of this protocol he started reaching levels of awakening so elevated that he realized he had already surpassed every single spiritual teacher that he had ever heard of. He started writing a manifesto explaining this, claiming that even the most enlightened humans are not truly as awake as he became during that week. That it had became “completely transparent that most people who say they are awake or teach awakening are not even 1% awake”. But he decided not to go forward with the manifesto because he still values the teachings of spiritual leaders, whom according to him are doing a great service to mankind. He didn’t want to start, what he called, a “nonduality war” (which is of course a fascinating term if you think about it).
The main thing I’d like to comment here is that Leo is never entirely clear about what makes an “awakening experience” authentic. From what I gather (and from what comes next in the video) we can infer that the leading criteria consists of a fuzzy blend of experience of certainty, feeling of unity, and sense of direct knowing coupled together. To the extent that 5-MeO-DMT does all of these things to an extraordinary degree, we can take Leo on his words that he indeed experienced states of consciousness that feel like awakening that are most likely inaccessible to everyone who hasn’t gone through a protocol like his. What is still unclear is how exactly the semantic contents of these experiences are verified by means other than intuition. We will come back to that.
At 16:00 he makes the distinction between awakening as merely “cessation”, “nothingness”, “emptiness”, “the Self”, or that “you are nothing and everything” versus what he has been experiencing. He agrees that those are true and worthy realizations, but he claims that before his experiences, these understandings were still only realized at a very “low level”. Other masters, he claims, may care about ending suffering, about peace, about emptiness, and so on. But that nobody seems to truly care about understanding reality (because otherwise they would be doing what he’s doing). He rebukes possible critics (arguably of the Zen variety) who would say that “understanding is a function of the mind” so the goal shouldn’t be to understand. He asserts that no, based on his lived experience, that consciousness is capable of “infinite understanding”.
Notwithstanding the challenges posed by ultrafinitism, I am also inclined to believe Leo that he has experienced completely new varieties of “understanding”. In my model of the mind, understanding something means to have the ability to render it in your world-simulation in a particular kind of way that allows you to see it from every possible angle you have access to. On 5-MeO-DMT, as we will see to a greater extent below, a certain new set of projective operations get unlocked that allow you to render information from many, many more points of view at the same time. It is unclear whether this is possible with meditation alone (in personal communication, Daniel Ingram said yes) but it is certainly extraordinarily rare for even advanced meditators to be able to do this. So I am with Leo when it comes to describing “new kinds of understandings”. But perhaps I am not on board when it comes to claiming that the content of such understandings is an accurate rendering of the structure of reality.
At 18:30 Leo asserts that what happened to him is that over the course of the first week of his experiment he “completely understood reality, completely understood what God is”. God has no beginning and no end. He explains that normal human understanding sees situations from a single point of view (such as from the past to the future). But that actual infinite reality is from all sides at once: “When you are in full God consciousness, you look around the room, and you can see it from every single point of view, from an infinite number of angle and perspectives. You see that every part of the room generates and manufactures and creates every other part. […] Here when you are in God consciousness, you see it from every single possible dimension and angle. It’s not happening lilnearly, it’s all in the present now. And you can see it from every angle almost as though, if you take a watermelon and you do a cross-section with a giant knife, through that watermelon, and you keep doing cross-section, cross-section, cross-section in various different angles, eventually you’ll slice it up into an infinite number of perspectives. And then you’ll understand the entire watermelon as a sort of a whole. Whereas usually as humans what we do is we slice down that watermelon just right down the middle. And we just see that one cross-section.”
Now, this is extremely interesting. But first, it’s important to point out that here Leo might implicitly be reasoning about his experience through the lens of direct realism about perception. That is, that as he experiences this profound sense of understanding that encompasses every possible angle at once, he seems to believe that this is an understanding of his environment, of his future and past, and of reality as a whole. On the other hand, if you start out assuming indirect realism about perception, how you interpret this experience would be in terms of the instantiation of new exotic geometries of your own world-simulation. Here I must bring up the analysis of “regular” DMT (i.e. n,n-DMT) experiences through the lens of hyperbolic geometry. Indeed, regular DMT elevates the energy of your consciousness, which manifests in brighter colors, fast movement, intricate and detailed patterns, and as curved phenomenal space. We know this because of numerous trip reports from people well educated in advanced mathematics who claim that the visual symmetries one can experience on DMT (at doses above 10mg) have hyperbolic curvature (cf. hyperbolic orbifolds). It is also consistent with many other phenomena one can experience on DMT (see the Eli 5 for a quick summary). But you should keep in mind that this analysis never claims that you are experiencing directly a mind-independent “hyperspace”. Rather, the analysis focuses on how DMT modifies the geometric properties of your inner world-simulation.
Intriguingly, our inner world-simulations work with projective geometry. In normal circumstances our world-simulations have a consistent set of projective points at infinity – they render the modal and amodal features of our experience in projective scenes that are globally consistent. But psychedelics can give rise to this phenomenon of “point-of-view-fragmentation“, where your experience becomes a patchwork of inconsistent projective renderings. So even on “regular” DMT you can get the profound feeling of “seeing something from multiple points of view at once”. Enhanced with hyperbolic geometry, this can cause the stark impression that you can explore “hyperspace” with a kind of “ultra-understanding”.
Looking beyond “regular” DMT, 5-MeO-DMT is yet more crazy than that. You see, even on DMT you get the feeling that you are restricted in the number of points of view from which you can see something at the same time. You can see it from many more points of view than normal, but it’s still restricted. But the extreme “smoothing” of experience that 5-MeO-DMT causes makes it so that you cannot distinguish one point of view from another. So they all blend together. Not only do you experience semantic content from “multiple points of view at once” as in DMT, but you can erase distinctions between points of view so that one’s sense of knowing arises involving a totally new kind of projective effect, in which you actually feel you can see something from “every point of view at once”. It feels that you have unlocked a kind of omniscience. This already happens on other psychedelics to a lesser extent (and in meditation, and even sober life to an even lesser extent, but still there), and it is a consequence of smoothing the geometry of your experience to such an extent that there are no symmetry-breaking imperfections “with which to orient a projective point”. I suspect that the higher “formless” jhanas of “boundless space” and “boundless consciousness” are hitting at this effect. And on 5-MeO-DMT this effect is pronounced. More so, because of the connection between symmetry and smoothness of space (cf. Geometry Through the Eyes of Felix Klein) when this happens you will also automatically be instantiating a high-dimensional group. And according to the Symmetry Theory of Valence, this ought to be extraordinarily blissful. And indeed it is.
This is, perhaps, partly what is going on in the experience that Leo is describing. Again, I am inclined to believe his description, but happy to dismiss his naïve interpretation.
At 23:15 Leo describes how from his 5-MeO-DMT point of view he realized what “consciousness truly is”. And that is an “infinitely interconnected self-communicating field”. In normal everyday states of consciousness the different parts of your experience are “connected” but not “communicating.” But on 5-MeO, “as you become more conscious, what happens is that every point in space inter-connects with itself and starts to communicate with itself. This is a really profound, shocking, mystical experience. And it keeps getting cranked up more and more and more. You can call it omniscience, or telepathy. And it’s like the universal communication system gets turned on for the first time. Right now your conscious field is not in infinite communication with itself. It’s fragmented and divided. Such that you think I’m over here, you are over there, my computer is over here, your computer is over there…”. He explains that if we were to realize we are all one, we would then instantly be able to communicate between each other.
Here again we get extremely different interpretations of the phenomena Leo describes depending on whether you believe in direct or indirect realism about perception. As Leo implicitly assumes direct realism about perception, he interprets this effect as literally switching on an “universal communication system” between every points in reality, whereas the indirect realist interpretation would be that you have somehow interlocked the pieces of your conscious experience in such a way that they now act as an interconnected whole. This is something that indeed has been reported before, and at QRI we call this effect “networkintegration“. A simple way of encapsulating this phenomenon would be by saying that the cross-frequency coupling of your nervous system is massively increased so that there is seamless information and energy transfer between vibrations at different scales (to a much lesser extent MDMA also does this, but 5-MeO-DMT is the most powerful “integration aid” we know of). This sounds crazy but it really isn’t. After all, your nervous system is a network of oscillators. It stands to reason that you can change how they interact with one another by fine-tuning their connections and get as a result decoupling of vibrations (e.g. SSRIs), or coupling only between vibrations of a specific frequency (e.g. stimulants and depressants), or more coupling in general (e.g. psychedelics). In particular, 5-MeO-DMT does seem to cause a massively effective kind of fractal coupling, where every vibration can get in tune with every other vibration. And recall, since a lot of our inner world simulation is about representing “external reality”, this effect can give rise to the feeling that you can now instantly communicate with other parts of reality as a whole. This, from my point of view, is merely misinterpreting the experience by imagining that you have direct access to your surroundings.
At 34:52 Leo explains that you just need 5-MeO-DMT to experience these awakenings. And yet, he also claims that everything in reality is imaginary. It is all something that you, as God, are imagining because “you need a story to deny that you are infinite consciousness.” Even though the neurotransmitters are imaginary, you still need to modify them in order to have this experience: “I’m talking about superhuman levels of consciousness. These are not levels of consciousness that you can access sober. You need to literally upgrade the neurotransmitters in your imaginary brain. And yes, your brain is still imaginary, and those neurotransmitters are imaginary. But you still need to upgrade them nevertheless in order to access some of the things I say.”
Needless to say, it’s bizarre that you would need imaginary neurotransmitter-mimicking molecules in your brain in order to realize that all of reality is your own imagination. When you dream, do you need to find a specific drug inside your dream in order to wake up from the dream? Perhaps this view can indeed be steel-manned, but the odds seem stacked against it.
At 38:30 he starts talking about his pornography collection. He assembles nude images of women, not only to relieve horniness, but also as a kind of pursuit of aesthetics. Pictures of nude super-models are some of the most beautiful things a (straight) man can see. He brings this up in order to talk about how he then at some point started exploring watching these pictures on 5-MeO-DMT. Recollecting this brings him to tears because of how beautiful the experiences were. He states “you’ve never really seen porn until you’ve seen it on 5-MeO-DMT.” He claims that he started to feel that this way he really felt that it is you (God) that is beautiful, which is manifested through those pictures.
A robust finding in the psychology of sexual attraction is that symmetry in faces is correlated with attractiveness. Indeed, more regular faces tend to be perceived as more beautiful. Amazingly, you can play with this effect by decorating someone’s face with face-paint. The more symmetrical the pattern, the more beautiful the face looks (and vice-versa). Arguably, the effect Leo is describing where people who are already beautiful become unbelievably pretty on 5-MeO-DMT involves embedding high-dimensional symmetries into the way you render them in your world-simulation. A lesser, and perhaps more reliable, version of this effect happens when you look at people on MDMA. They look way more attractive than what they look like sober.
Leo then brings up (~41:30) that he started to take 5-MeO-DMT on warm baths as well, which he reassures us is not as dangerous as it sounds (not enough water to drown if he experiences a whiteout). [It’s important to mention that people have died by taking ketamine on bath tubs; although a different drug, it is arguably still extremely dangerous to take 5-MeO-DMT alone on a bathtub; don’t do it]. He then has an incredible awakening surrendering to God consciousness in the bathtub, on 5-MeO-DMT, jerking off to beautiful women in the screen of his laptop. He gets a profound insight into the very “nature of desire”. He explains that it is very difficult to recognize the true nature of desire while on a normal level of consciousness because our desires are biased and fragmented. When “your consciousness becomes infinite” those biases dissolve, and you experience desire in its pure form. Which according to his direct experience turned out to be “desire for God, desire for myself”. And this is because you are, deep down “infinite love”. When you desire a husband, or sex, or whatever, you are really desiring God in disguise. But the problem is that since your path to God is constrained by the form you desire, your connection to God is not stable. But once you have this experience of complete understanding of what desire is, you finally get your desire fully quenched by experiencing God’s love.
This is a very deep point. It is related to what I’ve sometimes called the “most important philosophical question“, which is: is valence a spiritual phenomenon or spirituality a valence phenomenon? In other words, do we find experiences of God blissful because they have harmony and symmetry, or perhaps is it the other way around, where even the most trivial of pleasures, like drinking a good smoothy, feels good because it temporarily “gets you closer to God”? I lean towards the former, and that in fact mystical experiences are so beautiful because they are indeed extremely harmonious and resonant states of consciousness, and not because they take you closer to God. But I know very smart people who can’t decide between these views. For example, my friend Stuart Garvagh writes:
What if the two options are indistinguishable? Suppose valence is a measure of the harmony/symmetry of the object of consciousness, and the experience of “Oneness” or Cosmic Consciousness is equivalent to having the object of consciousness be all of creation (God‘s object), a highly symmetrical, full-spectrum object (full of bliss, light, love, beingness, all-knowledge, empty of discernible content or information). All objects of consciousness are distortions (or refractions, or something) of this one object. Happiness is equivalent to reducing or “polishing-out” these distortions. Thus, what appears to be just the fact of certain states being more pleasant than others is equivalent to certain states being closer to God‘s creation as a whole. Obviously this is all pure speculation and just a story to illustrate a point, but I could see it being very tough to tease apart the truth-value of 1 and 2. Note: I’m fairly agnostic myself, but lean towards 2 (bliss is the perfume of “God realizing God” or the subject of experience knowing Itself). I would very much love to have this question answered convincingly!
At 50:00 Leo says that “everything I’ve described so far is really a prelude to the real heart of awakening, which is the discovery of love. […] I had already awakened to love a number of times, but this was deeper. By the two week mark the love really started to crack open. Infinite self-love. You are drowning on this love.” He goes on to describe how at this point he was developing a form of telepathy that allowed him to communicate with God directly (which is, of course, a way of talking to himself as he is God already). It’s just a helpful way to further develop. And what God was showing him was how to receive self-love. It was so much at first he couldn’t handle it. And so he went through a self-purification process.
An interesting lens with which to interpret this experience of purification is that of neural annealing. Each 5-MeO-DMT experience would be making Leo’s nervous system resonate in ways in new ways, slowly writing over previous patterns and entraining the characteristic high-symmetry patterns of the state. Over time, the nervous system adjusts its weights in order to be able to handle that resonance without getting its patterns over-written. In other words, Leo has been transforming his nervous system into a kind of high-valence machine, which is of course very beneficial for intrinsic feelings of wellbeing (though perhaps detrimental to one’s epistemology).
55:00: He points out that unlike addictive drugs, he actually had to push himself very hard to continue to take 5-MeO-DMT everyday for 30 days. He stopped wanting to do it. The ego didn’t want it. And yes, it was pleasurable once he surrendered on every session, but it was difficult, heavy spiritual work. He says that he could only really do this because of years of practice with and without psychedelics, intense meditation, and a lot of personal development. And because of this, he explains his 5-MeO experiences felt like “years of spiritual work condensed into a single hour.” He then says that God will never judge you, and will help you to accept whatever terrible things you’ve done. And many of his subsequent trips were centered around self-acceptance.
Following the path of progressive neural annealing, going deeper and deeper into a state of self-acceptance can be understood as a deeper harmonization of your nervous system with itself.
At 1:01:20, Leo claims to have figured out what the purpose of reality truly is: “Reality is a contest for who can love who more. That’s really what life is about when you are fully conscious. […] Consciousness is a race for who can love who more. […] An intelligent fully conscious consciousness would only be interested in love. It wouldn’t be interested in anything else. Because everything else is inferior. […] Everything else is just utter silliness!”
I tend to agree with this, though perhaps not in an agentive way. As David Pearce says: “the pleasure-pain axis discloses the universe’s intrinsic value function.” So when you’ve annealed extremely harmonious patterns and do not get distracted by negative emotion, naturally, all there is left to do is maximize love. Unless we mess up, this is the only good final destiny for the cosmos (albeit perhaps it might take the form of a Hedonium shockwave, which at least in our current human form, sound utterly unappealing to most people).
1:06:10 “[God’s love] sparks you to also want to love it back. You see, it turns into a reciprocal reaction, where it is like two mirrors that are mirroring light between each other like a laser beam that is bouncing between two mirrors. And it’s bouncing back and forth and back and forth. And as it bounces back and forth it becomes more and more concentrated. And it strengthens. And it becomes more coherent. And so that’s what started happening. At first it started out as just a little game. Like ‘I love you, I love you, I love you’. A little game. It sounds like it’s almost like childish. And it sort of was. But then it morphed from being this childish thing, into being this serious existential business. This turned into the work. This was the true awakening. Is that with the two mirrors, you know, first it took a little while to get the two mirrors aligned. Because you know if the two mirrors are not perfectly aligned, the laser beam will kind of bounce back and forth in different directions. It’s not going to really concentrate. So that was happening at first. […] The love started bouncing back and forth between us, and getting stronger and stronger. […] Each time it bounces back to me it transforms me. It opens me up deeper. And as it opens me up deeper it reveals blockages and obstacles to my capacity to love.”
Now this is a fascinating account. And while Leo interprets it in a completely mystical way, the description also fits very well an annealing process where the nervous system gets more and more fine-tuned in order to be able to contain high levels of coherent energy via symmetry. Again, this would be extremely high-valence as a consequence of the Symmetry Theory of Valence. Notice that we’ve talked about this phenomenon of “infinite mirrors” on psychedelics since 2016 (see: Algorithmic Reduction of Psychedelic States).
At ~1:09:30 he starts discussing that at this point he was confronted by God about whether he was willing to love the holocaust, and rape, and murder, and bullies, and people of all sorts, even devil worshipers.
Two important points here. First, it is a bit ambiguous whether Leo here is using the word “love” in the sense of “enjoyment” or in the sense of “loving-kindness and compassion”. The former would be disturbing while the latter would be admirable. I suppose he was talking about the latter, in which case “loving rape” would refer to “being able to accept and forgive those who rape” which indeed sounds very Godly. This radical move is explored in metta (loving-kindness) meditation and it seems healthy on the whole. And second: Why? Why go through the trouble of embracing all the evil and repulsive aspects of ourselves? One interpretation here, coming back to the analysis based on neural annealing, is that any little kink or imperfection caused by negative emotion in our nervous system will create slight symmetry breaking effects on the resonance of the entire system as whole. So after you’ve “polished and aligned the mirrors for long enough” the tiny imperfections become the next natural blockage to overcome in order to maximize the preservation of coherent energy via symmetry.
~1:12:00 Leo explains that the hardest thing to love is your own self-hatred. In the bouncing off of the love between you and God, with each bounce, you find that the parts you hate about yourself reflect an imperfect love. But God loves all of you including your self-hatred. So he pings you about that. And once you can accept it, that’s what truly changes you. “Because when you feel that love, and you feel how accepting it is, and how forgiving it is of all of your evil and of all of your sins… that’s the thing that kills you, that transforms you. That’s what breaks your heart, wide open. That’s what gets you to surrender. That’s what humbles you. That’s what heals you.” Leo then explains that he discovered what “healing is”. And it is “truth and love”. That in order to heal anyone, you need to love them and accept them. Not via sappy postcards and white lies but by truth. He also states that all physical, mental, and spiritual ailments have, at their root, lack of love.
If love is one of the cleanest expressions of high-valence symmetry and resonance, we can certainly expect that inundating a nervous system with it will smooth and clean its blockages, i.e. the sources of neural dissonance. Hence the incredible power of MDMA on healing nervous systems in the short-term. Indeed, positive emotion is itself healing and enhances neural coherence. But where I think this view is incomplete is in diagnosing the terrible suffering that goes on in the world in terms of a lack of love. For instance, are cluster headaches really just the result of lack of self-love? In here must bring back the background assumption of physicalism and make a firm statement that if we fall into illusion about the nature of reality we risk not saving people (and sentient beings more generally) who are really in the depth of Hell. Just loving them without taking the causally-relevant physical action to prevent their suffering is, in my opinion, not true love. Hence the importance of maintaining a high level of epistemic rigor: for the sake of others. (See: Hell Must Be Destroyed).
1:22:30 Leo explains that in this “love contest” with God of bouncing off love through parallel mirrors the love became so deep that for the first time in his life he felt the need to apologize: “I’m sorry for not loving more.” He goes into a sermon about how we are petty, and selfish, etc. and how God loves us anyway. “Real love means: I really love you as you are. And I don’t need anything from you. And especially all those things that you think I want you to change about you, I don’t need you to change. I can accept them all exactly as they are. Because that’s love. And when you realize THAT, that’s what transforms you. It is not that God says that he loves you. He is demonstrating it. It’s the demonstration that transforms you.” Leo expresses that he was then for the first time in his life able to say “thank you” sincerely. Specifically, “thank you for your love”: “This is the point at which you’ve really been touched by God’s love. And at this point you realize that that’s it, that’s the point, that’s the lesson in life. That’s my only job. It’s to love.” And finally, that for the first time in his life he was able to say “I love you” and truly mean it. “And you fall in love with God… but it doesn’t end there.”
An interesting interpretation of the felt-sense of “truly meaning” words like “I’m sorry”, “thank you”, and “I love you” is that at this point Leo has really deeply annealed his nervous system into a vessel for coherent energy. In other words, at this point he is saying and meaning those words through the whole of his nervous system, rather than them coming from a fragmented region of a complex set of competing internal family systems in a scattered way. Which is, of course, the way it usually goes.
1:35:30 Leo explains that at this point he started going into the stage of being able to radiate love. That he was unable to radiate love before. “I love that you are not capable of love. I love that. And when that hits you, that’s what fills you with enough love to overcome your resistance to love that next level thing that you couldn’t love.” Then at ~ 1:38:00 it gets really serious. Leo explains that so far he was just loving and accepting past events and people. But he was then asked by God whether he would be willing to live through the worst things that have happened and will happen. To incarnate and be tortured, among many other horrible things. And that’s what true love really means. “When you see a murder on the TV, you have to realize that God lived through that. And the only reason he lived through that is because it loved it.”
I do not understand this. Here is where the distinction between the two kinds of senses of the word “love” become very important. I worry that Leo has annealed to the version of love with the meaning of “enjoyment” rather than “loving-kindness and compassion”. Because a loving God would be happy to take the place of someone who went through Hell. But would a loving God send himself to Hell if nobody had to in the first place? That would just create suffering out of nothing. So I am confused about why Leo would believe this to be the case. It’s quite possible that there are many maxima of symmetry in the nervous system you can achieve with 5-MeO-DMT, and some of them are loving in the sense of compassionate and others are crazy and would be willing to create suffering out of nothing from a misguided understanding of what love is supposed to be. Again, handle Plutonium with caution.
1:43:00 Leo started wondering “what is reality then?” And the answer was: “It’s infinite consciousness. Infinite formless consciousness. So what happens was that my mind in my visual field as I was in that bathtub. My mind and my visual field focused in on empty space, and I sort of zoomed into that empty space and realized that that empty space is just love”. He then describes a process where his consciousness became more and more concentrated and absorbed into space, each dot of consciousness branching out into more and more dots of consciousness, turning into the brightest possible white light. But when he inquired into what was that white light he kept seeing that there was no end to it, and rather, that each point was always connected to more points. Inquiring further, he would get the response that at the core, reality is pure love. That it wouldn’t be and couldn’t be any other way.
The description sounds remarkably close to the formless jhanas such as “boundless space” and “boundless consciousness”. The description itself is extremely reminiscent of an annealing process, reaching a highly energized state of consciousness nearly devoid of information content and nearly perfectly symmetrical. The fact that at this incredibly annealed level he felt so much love supports the Symmetry Theory of Valence.
147:28 – And after Leo realizes that “Of course it is love!” he says that’s when the fear comes: “Because then what you realize is that this is the end. This is the end of your life. You are dead. If you go any further you are dead. Everything will disappear. Your family, your friends, you parents, all of it is completely imaginary. And if you stop imagining it right now, it will all end. If you go any further into this Singularity, you will become pure, formless, infinite, love for ever, loving itself forever. And the entire universe will be destroyed as if it never existed. Complete nothingness. Complete everythingness. You will merge into everyone.”
This sounds like the transition between the 6th and 7th Jhana, i.e. between “boundless consciousness” and “nothingness”. Again, this would be the result of further loss of information via an annealing process, refining the symmetry up to that of a “point”. Interestingly, Mike Johnson in Principia Quallia points out that as symmetry approaches an asymptote of perfection you do get a higher quality of valence but at the cost of reduced consciousness. This might explain why you go from “the brightest possible love” to a feeling of nothingness at this critical transition.
1:48:25: “…You will merge into everyone. Your mother, your father, your children, your spouse, Hitler, terrorists, 9/11, Donald Trump, rape, murder, torture, everything will become pure infinite love, merging completely into itself, there will be no distinction between absolutely anything, and that will be the end. And you will realize what reality is. Infinite consciousness. Love. God. And you will realize that everything in your life from your birth to this point has just been some imaginary story. A dream that was design to lead you to pure absolute infinite love. And you will rest in that love forever. Forever falling in love with yourself. Forever making love to yourself. Forever in infinite union. With every possible object that could ever exist. Pure absolute, omnipotent, omniscient, perfect, intelligent, consciousness. Everything that could ever possibly be, is you. And THAT is awakening. When you are this awake, you are dead. And you have no desire for life. There is no physical existence. There is no universe. Nothing remains. Your parents, and your spouse, and your children, they don’t stay back and keep living their lives, enjoying their life without you while your body drops dead. No, no, no, no, no. This is much more serious than that. If you do this. If you become infinite love, you will take everybody with you. There will not be anybody left. You will destroy the entire universe. Every single sentient being will become you. They will have no existence whatsoever. Zero. They will die with you. They will all awaken with you. It’s infinite awakening. It’s completely absolute. There will not be anything left. You will take the entire universe with you. Into pure oneness. THAT’S awakening.”
This is not the first time I hear about this kind of experience. It certainly sounds extraordinarily scary. Though perhaps a negative utilitarian would find it to be the ultimate relief and the best of all possible imaginable outcomes. With the human survival instinct, and quite possibly a body fully aroused with the incredible power of 5-MeO-DMT, this is bound to be one of the most terrifying feelings possible. It’s quite likely that it may be one element of what makes “bad 5-MeO-DMT experiences” so terrifying. But here we must recall that the map is not the territory. And while an annealing process might slowly write over every single facet of one’s model of reality and in turn making them part of a super-cluster of high-dimensional resonance that reflects itself seemingly infinitely, doing this does not entail that you are in fact about to destroy the universe. Though, admittedly, it will surely feel that way. Additionally, I would gather that were it possible to actually end the universe this way, somebody, somewhere, in some reality or another, would have already done so. Remember that if God could be killed, it’d be dead already.
1:52:01: “And I didn’t go there! As you can tell, since I’m still sitting here. I’m not there. I was too afraid to go there. And God was fine with it. It didn’t push me. But that’s not the end of the story! It’s still just the beginning.” He then goes on to explain that a part of him wanted to do it and another part of him didn’t want to. He says it got really loopy and weird; this really shook him. That God was beckoning him to go and be one forever, but he was still ambivalent and needed some time to think about it. He knew it would make no difference, but he still decided to ‘make preparations’ and tell his family and friends that he loves them before moving forward with a final decision to annihilate the universe. By the time he had done that… he had stopped taking 5-MeO-DMT: “The experiences had gotten so profound and so deep… this was roughly the 25th or 27th day of this whole 30 day process. I swore off 5-MeO-DMT and said ‘Ok I’m not doing any more of this shit. It’s enough’”. He explains that by this time the drug was making him feel infinite consciousness when waking up (from sleep) the next day. He felt the Singularity was sucking him into it. It felt both terrifying and irresistible. Every time he would go to sleep it would suck him in really strongly, and he kept resisting it. He would wake up sweaty and in a panic. He was tripping deeper in his sleep than in the bathtub. He couldn’t sleep without this happening, and it kept happening for about 5 days. “I just want to get back to normal. This is getting freaky now.”
I’ve heard this from more than a couple people. That is, that when one does 5-MeO-DMT enough times, and especially within a short enough period of time, the “realizations” start to also happen during sleep in an involuntarily way. One can interpret this as the annealing process of 5-MeO-DMT now latching on to sleep (itself a natural annealing process meant to lessen the technical debt of the nervous system). Even just a couple strong trips can really change what sleep feels like for many days. I can’t imagine just how intense it must have been for Leo after 25 days straight of using this drug.
2:01:40 – Leo explains that when he was dozing off with a blanket on his living room (terrified of sleeping on his bed due to the effect just described) he experienced a “yet deeper awakening” which involved realizing that all of his previous awakenings were just like points and that the new one was like a line connecting many points. “Everything I’ve said up to this point were just a single dimension of awakening. And then what I broke through to is a second dimension. A second dimension of awakening opened up. This second dimension is completely unimaginable, completely indescribable, cannot be talked about, cannot be thought about. And yet it’s there. In it, are things that are completely outside of the physical universe that you cannot conceive or imagine.” He goes on to explain that there are then also a third, fourth, fifth, etc. dimensions. And that he believes there is an infinite number of them. He barely even began to explore the second dimension of awakening, but he realized that it goes forever. It kept happening, he had intense emotional distress and mood swings. But gradually after five more days it subsided, and he started to be able to sleep more normally. “And I’ve been working to make sense of all of this for the last couple of weeks. So that’s what happened.”
Alright, this is out of my depth and I do not have an interpretation of what this “second dimension of awakening” is about. If anyone has any clue, please leave a comment or shoot me an email. I’m as as confused as Leo is about this.
~2:05:00 – Leo confesses he does not know what would happen if he went through with joining the Singularity and mentions that it sounds a bit like Mahasamādhi. He simply has not answers at this point, but he asserts that the experience has made him question the extent of the enlightenment of other teachers. It also has made him more loving. But still, he feels frustration: “I don’t know what to do from here.”
Postscript: In the last 10 minutes of the video Leo shares a heart warming message about how reality is, deep down, truly, “just love” and that him saying this may be a seed that will blossom into you finding this out for yourself at some point in the future. He ends by cautioning his audience to not believe as a matter of fact that this is the path for everyone. He suggests that others should just use his examples from his own journey as examples rather than an absolute guide or how-to for enlightenment. He asks his audience to make sure to question the depth of their own awakening – to not believe that they have reached the ultimate level. He admits he has no idea whether there is an ultimate level or not, and that he still has some healing to do on himself. He remains dissatisfied with his understanding of reality.
Thank you for reading!
Imagine that you were tasked with creating a molecule to represent the spirit of California. I think that I would just glue together two MDMA molecules and call it a day.
It turns out Californidine is indeed a real molecule, named after the California Poppy. I am still wrapping my head around the fact that Californidine can be described as two MDMA molecules sharing the nitrogen atom and with the end of the carbon chain of each MDMA molecule bonded at the 2-position of the benzene ring of the other one (minus a hydrogen atom). Interestingly, this compound has no psychedelic or empathogenic action. At best, it can be described as a very mild and unreliable relaxing agent of “herbal strength” akin to the active ingredients of chamomile, valerian, or ashwagandha. So, joining two powerful heart-openers gives rise to a mild sleep-inducer? Perhaps this is a metaphor for something.
But that’s not what I want to talk to you about today. While gluing together psychoactive molecules may not have a (cartoonishly) desirable additive effect, doing so does express the spirit of what I want to propose today. And that is the impulse to use a creative and fun approach to drug design, letting your imagination run wild to avoid prematurely discarding one’s crazy ideas.
Notable Leads for Great Drug Combos
Over the last 10 years I’ve read many (many!) trip reports and have talked to hundreds of experienced psychonauts (see also: r/replications). It is largely thanks to a subset of these psychonauts, which for lack of a better term could be described as the subset of rational psychonauts, that I’ve been able to assemble empirically testable models for psychedelic phenomenology (some examples: Algorithmic Reduction of Psychedelic States, Hyperbolic Geometry of DMT Experiences, Quantifying Bliss, How to Secretly Communicate with People on LSD, etc.). Although my focus has largely been on the effects of individual drugs, I’ve become very cognizant of the fact that drug combinations can produce effects not accessible with individual substances. In other words, when it comes to mixing psychoactive substances, the sum is more often than not different from the sum of its parts. Some of these effects seem extremely significant both from a scientific and a philosophical point of view.
But first, an important disclaimer: mixing drugs is dangerous and you should never do it unless you really know what you are doing. The pile of celebrity deaths caused by multiple drug intoxication is only scratching the surface. Indeed, there are many combinations of drugs that are deadly even when the individual drugs taken on their own are relatively safe. For example, while 5-MeO-DMT is relatively safe when vaporized (save for egregiously negligent uses of the drug and the occasional drowning in one’s own vomit), taking 5-MeO-DMT orally in combination with an MAOI leads to extremely toxic reactions, such as severe hypertensive symptoms, overheating, and serotonin syndrome. Don’t do it. As a very rough guide for how mixtures of psychoactives behave, study the chart below.
Welcome to the practice of combining drugs. You may die. (source)
That said, just as drug combinations have a dangerous side, they also likely harbor hidden gems that are very safe, enjoyable, and mind-expanding in ways inaccessible via single drugs. As a general overview, some examples of the possible benefits of drug combinations include: (1) Enhanced euphoria, e.g. see speedball which is massively euphoric but also very dangerous, (2) reduced psychological discomfort (e.g. anxiolytics with psychedelics), (3) uniquely interesting effects, e.g. LSD + MDMA (see below), and (4) reduced physical side-effects and medical risks, e.g. calcium blockers to reduce MDMA neurotoxicity, 5HT2B antagonists to reduce cardiotoxicity of psychedelics, etc. as we’ll discuss. In addition, it is worth mentioning that from a therapeutic point of view, we also have the “more dakka effect“, where some conditions only respond to combining enough drugs (e.g. oncology). It’s possible chronic pain or severe depression may legitimately require multiple drugs to be adequately dealt with. Now let us examine in more detail some particularly interesting categories of drug combinations:
Psychedelics + Anxiolytics: According to many reports, phenibut in small doses seems to significantly reduce the anxiety that comes up on psychedelics. I am ambivalent about sharing this information given the fact that phenibut can become a huge problem for some people, but I think that on the whole it is wise for people to know that an over-the-counter “nootropic” can actually help avoid fear, discomfort, and panic attacks during a psychedelic experience.
Cannabis + Psychedelics: I generally find two kinds of psychedelic drug users. Those who cannot think of having a psychedelic trip without at some point smoking a joint, vaping, or eating a cannabis edible. And then those who would never dare to combine the two because they once had a terrifying experience with the combo. Interestingly, some of the people I’ve met over the years who seem to be able to easily handle massive doses of psychedelics (e.g. 500 micrograms of acid) respond terribly to weed, and especially badly if they are already tripping. Cannabis both modifies and potentiates psychedelic states of mind. It has a tendency to make the experience more conceptual rather than sensory or mystical. The combination also greatly increases the probability of getting stuck in time loops.
Empathogens + Psychedelics: One of the best descriptions of MDMA + LSD (also called candy-flipping) that I’ve found comes from Steven Lehar (emphasis added):
Under LSD and ecstasy I could see the flickering blur of visual generation most clearly. And I saw peculiar ornamental artifacts on all perceived objects, like a Fourier representation with the higher harmonics chopped off. LSD by itself creates sharply detailed ornamental artifacts, like a transparent overlay of an ornamental lattice or filigree pattern superimposed on the visual scene, especially in darkness. Ecstasy smooths out those sharp edges and blurs them into a creamy smooth rolling experience. I would sometimes feel some part of my world suddenly bulging out to greater magnification, like a fish-eye lens distortion appearing randomly in space, stretching everything in that portion of space like a reflection in a funhouse mirror.
Not everyone responds well to this combination, and given the nature of these substances, it seems likely that the dosages and the relative timing have a large influence on how the experience develops. I’ve heard three relatively “established” ways in which people use this combination. First, you have the school that says that you should take the MDMA at or slightly after the peak of the effects of LSD, that is 4-4:30h after taking it. The reasoning here is that you don’t want to be caught coming down from the MDMA while still having a long time to go on LSD since the acid could enhance the feelings of the comedown. The delayed gratification also pays-off by giving you several hours to face the problems you want to solve unaided and see how far you can get before the mood boost of MDMA gives you the determination to be contented with it.
The second school of thought about candy-flipping says that the biggest factor in how psychedelic experiences turn out is how they start. So what you want to do is take the MDMA 1 to 1:30 hours before the acid. This way, you only embark upon the inner journey when you are already in a really, really good chill state of mind. Some people report that the acid picks up the empathogenic quality of the state, amplifies it, and carries it on for much longer than if you had only taken MDMA alone.
There are many proponents and detractors to both of these schools. What I’ve seen more or less everyone agree on is to avoid taking substantial doses of LSD and MDMA (e.g. 200micrograms LSD + 120mg MDMA) at the same time. Apparently this is simply just too overwhelming and synergistic to be enjoyable, often causing a lot of nausea and palpitations.
The third school, however, is to take only a small dose of both at the same time. Say, 35micrograms LSD and 35mg MDMA. This apparently is an extremely positive combination. The experience is not mild due to the synergy, and it seems to provide an open, creative, level-headed mindset for many hours without much of a comedown or hangover. As with everything here, your mileage may vary.
Psychedelics + Dissociatives: Psychedelics and dissociatives have profound non-linear mixing effects. According to multiple sources, the right combination of LSD, Ketamine, and THC can give rise to a “free-wheeling hallucination“. This is a state of consciousness in which you gain a great degree of conscious control over the contents of the hallucinated world, so that you can project your will by saying “let there be a chair in front of me” and you will see it manifest in exquisite detail. You can rotate, translate, invert, fibrate, and project the chair in any way you want, as if you were now able to use your brain as a very general game engine of consciousness. That said, even when this doesn’t happen, the combination of psychedelics and dissociatives is ridiculously synergistic. People report getting stuck in extremely energetic time-loops akin to those caused by psychedelics and cannabis, but more powerful (cf. trip report of DMT + nitrous oxide). Steven Lehar calls the effect where the presence of a psychedelic changes the quality of a dissociative as “dissociative coloring”. I’ve been amazed at the fact that there is no mistaking when someone has previously experienced LSD and nitrous together. You don’t get reactions like “it didn’t do much for me”. This combo usually has a special place in the memory of a person who has experienced it. Eyes brighten, curiosity sparks. I’ve been asked on multiple occasions “what do you think is going on with the strange synergy between LSD and nitrous?” Now, 5-MeO-DMT and DMT are very different, and the LSD + nitrous state seems to have some resemblance with the 5-MeO-DMT state. They share that strange feeling of becoming a kind of saturated resonance box. The feeling is one of becoming a vessel full of coordinated and coherent vibrations that unearth and dissolve internal boundaries and blockages. The process inherently blocks your ability to conceptualize in a dualistic way. The cognitive content of the state is better captured by a huge blinking sign that reads “THIS, THIS, THIS” on repeat rather than the more usual “that thing over there connected to this over here, modulated by what happens there” kind of cognitive state we are more familiar with. DMT on its own is very different than this, in that the mental formations and patterns of binding that emerge are extremely specific, detailed, and irreducibly complex. Not so on the upper ranges of the dissociative and psychedelic cocktail, where the resonance is profound and the asymmetries needed to store complex information are constantly smoothed out by the ongoing full-body bath of reverb. (cf. Neural Annealing).
Dissociatives + Empathogens: According to several trip reports and credible personal communications, taking ketamine while on MDMA can bring back “the magic” that one only ever experienced with MDMA the first few times using it. Also MDMA and nitrous have profound research-worthy synergy.
Potentiation: Shulgin reported that substances that don’t feel psychedelically active on their own may nonetheless potentiate the effects of other psychedelics. For instance:
(with 160 mg of MDPR followed at 2h by 100μg LSD) This proved to be almost too intoxicating, and a problem arose that had to have a solution. The entire research group was here, and all were following this same regimen. Two hours into the second half of the experiment a telephone call came that reminded me of a promise I had made to perform in a social afternoon with the viola in a string quartet. Why did I answer the phone? My entire experience was, over the course of about 20 minutes, pushed down to a fragile threshold, and I drove about 10 minutes to attend a swank afternoon event and played an early Beethoven and a middle Mozart with an untouched glass of expensive Merlot in front of me. I could always blame the booze. I declined the magnificent food spread, split, and returned to my own party. Safely home, and given 20 more minutes, I was back into a rolling +++ and I now know that the mind has a remarkable ability to control the particular place the psyche is in.
More common than the above, ayahuasca is intrinsically a drug combo primarily of the potentiation kind. As mentioned before, cannabis not only alters but also potentiates the effects of psychedelics. It is worth mentioning there is a community of people who believe that noopept (a cholinergic nootropic, see below) can potentiate MDMA. While there is some evidence that MDMA is itself mildly cholinergic– and thus provides a sense of mental clarity in addition to the loved-up feeling- too much cholinergic action tends to make people feel rigid, robotic, and hyper-cerebral. I am therefore personally skeptical of the benefits of combining something like noopept with MDMA, as the potentiation of some of its qualities may come at the cost of reduced emotional sensitivity. Why trade a feeling of renewed innocence and receptivity with calculating prowess? I doubt this is the best use of a roll.
Anti-tolerance Drugs: This is a category of combinations with tremendous potential to relieve suffering, to the extent that I think of it as a humanitarian tragedy that there are no concerted research efforts currently in this direction. Sufferers of chronic pain and treatment-resistance depression could make use of drugs that help them keep the tolerance to the drugs they depend upon for having a livable life under control. I know this has a lot of the ring of turtles all the way down (“when are you going to get the anti-tolerance drugs for anti-tolerance drugs? And then the anti-tolerance for anti-tolerance for…”) but I am sincere when I say that looking here may pay off in spades. Already we see ibogaine doing other-worldly magnificent things to cure addiction and reverse tolerance. Who knows what a large targeted research program with this focus may discover. Some examples of anti-tolerance drugs include proglumide, ibogaine, and black seed oil for opioids, and flumazenil for benzodiazepines.
Prevent Physical Side Effects: Epidemiological data suggests that chronic or heavy use of 5HT2B agonists may lead to heart valve disease (cf. Fen-Phen), which does not bode well for the long-term (as opposed to acute) safety of many psychedelic compounds. Now, neuroscientist Thomas Ray believes that 5HT2B may be necessary for some of the characteristic psychedelic action of entheogens, so blocking it altogether may come at the cost of eliminating the reason why the drug is interesting. That said, we do know that 5-MeO-DMT is profoundly psychedelic and yet has negligible 5HT2B activity. It would be very useful to know what happens when one combines psychedelics with heavy 5HT2B affinity, like 2C-B and DOB, with 5HT2B antagonists (usually prescription medicines). Would blocking 5HT2B agonism avoid cardiotoxicity? And what would the drug feel like then? Another interesting lead is the affinity of compounds like 2C-E and 2C-T-2 to the 5HT3 receptor, which is predominantly in the gut and modulates feelings like nausea. Additionally, since 5HT3 antagonists are antiemetic it really stands to reason that taking one before e.g. tripping on shrooms may give you a much less, ahem, visceral experience. Finally, I would like to explore the implications of the fact that of all of the compounds in Ray’s study the only one with significant affinity for calcium channels is MDMA. Would this be related to its neurotoxicity? And would taking a calcium channel blocker prevent it? It might still be wise regardless simply as a way to lessen the cardiac load of the compound.
Nootropic Stacks (cf. the Qualia Pill): Many people who explore nootropics make “stacks”. That is, rather than taking only piracetam, they might take a combination of piracetam, aniracetam, pramiracetam, coluracetam, and l-tyrosine. I suspect that this is popular because most nootropics are pretty mild and often hard to notice, and people want to be able to feel the effects. I generally do not think this is sensible, though, as we don’t understand these substances well enough. More so, branded “nootropic stacks” can have upwards of 30 different psychoactive substances crammed together in half a dozen pills you are supposed to take daily. While I do think there are likely gems to be found in the vast combinatorial space of cognition-boosting chemicals, I simply do not see any way in which the current major brands of nootropic stacks could have done the type of research needed to find them. I therefore do not personally recommend you go out and try such combos, at least not until we know a lot more about how to do combinations properly. If you want to try nootropic stacks, I’d recommend you start with small doses of two or three well-researched nootropics at most and do your own research thoroughly before settling on a particular combination.
Psychedelics and Psychedelics: A classic psychedelic combo that I’ve heard a lot about is LSD + DMT. The state that emerges from this combination is apparently unique, though if you take enough DMT the LSD fades into the background. Apparently psychedelics tend to have a characteristic spectral effect on your brain’s harmonics (see: Connectome-Specific Harmonic Waves on LSD), which manifests in the form of experiencing “vibes of different frequencies” specific to the drug you are taking. The case of LSD and DMT is very interesting, since their characteristic frequencies are sufficiently far apart (to put a number on it, LSD may be in the vicinity of 18Hz while DMT may be close to 30Hz) that they can be separated easily. You thus get a spectral effect of two peaks interfering with one another, oftentimes creating a powerful 3D grid of Moiré patterns, like a super-charged version of the “regular” DMT Chrysanthemum. As a method for spectral analysis, studying the beat patterns of psychedelic drug combos could go a long way in formulating a systematic characterization of their phenomenology. Speculatively, this may even allow us to come up with specific psychedelic drug cocktails that produce maximally consonant harmonious effects.
A final thought to add to this section concerns the fact that people respond differently to drugs. One can reason that if drug A affects 20% of people in a different way while drug B affects 10% of people in a different way, that A + B would lead to 4 different kinds of responses. More so, the more drugs you pile on top of each other, the more specific and individualized the response would be. I think that this is likely true in the general case, but I would argue that it is not universally true. A useful analogy here is with the way people respond to the scent of different molecules: you may lack the gene that encodes the receptor for a particular molecule, but perfumes usually have 30 or more scent-contributing molecules, so the experience of a perfume may be more similar between people than their experience of individual molecules. At the extreme, we have the phenomenon of “white noise scent” where once you mix 40+ molecules in equal (intensity-adjusted) proportions that span scent-space, it all starts smelling the same. The notion of “scent entropy” can be imported to drugs as well: I would expect a kind of inverted U-curve for “how idiosyncratic” the responses to drug combinations are as a function of the total entropy of the combo.
Drug Cocktails From First Principles
The way we aim to understand psychoactive substances at the Qualia Research Institute is in terms of the way they modify the neuroacoustic profile of the brain. And while this is what I see as the most promising approach moving forward, I believe that there is nonetheless a lot of low-hanging fruit at the receptor level of analysis.
The first time I’d thought of trying to emulate the effects of a drug using a cocktail of other drugs came up years ago when I found out that MDMA is likely neurotoxic. At the time I thought perhaps it was just a matter of getting the right dopaminergic, serotonergic, and oxytocinergic activity going for you to replicate the MDMA high. It’s a good thought, and some people have taken it to heart, such as the creators of “Poly”, an MDMA-like cocktail (cf. Kisspeptine). But as we’ll see, MDMA is more complex than that, and we may need to consider far more variables to make a “credible MDMA substitute”.
Looking beyond drug combos of only two or three drugs, and with a nod to concepts from the field of high-entropy alloys (HEAs), we could start thinking about the secret gems to be found in the vast combinatorial space of “high-entropy drug combos”. But what kind of principles could we use to safely combine 5+ drugs? The full story will probably be much, much more complicated than the following approach, but it is still nonetheless worth exploring as a first pass. Namely, to break down each drug in terms of their receptor affinity profile and then use those affinities additively to create arbitrary “synthetic” receptor affinity profiles. There are many reasons why this might not work: receptor affinity may not work linearly or have a clear rule-based behavior. For instance, it is still unclear if a single drug that has affinity for key serotonin receptors (say 5HT2A, 5HT2B, and 5HT7) in addition to working as an NMDR antagonist would produce the same feeling of “synergistic action” as there is between psychedelics and dissociatives. More so, there could be additional intra-cellular signaling specific to each molecule, so that two molecules that work as agonists with the exact same 5HT2B affinity may have different downstream effects inside the neuron, and then those intracellular effects might have phenomenological properties of their own. But leaving all of those caveats and unknowns aside for a moment, what would it look like to create drug cocktails with this method?
After giving it some thought I realized that the problem can be reduced to a non-negative least squares (NNLS) optimization (non-negative because, as they say: “you can always take more drugs, but you cannot take less drugs”). It turns out there are already open source implementations of algorithms that solve this optimization problem (for both R and Python)*. So I downloaded the data from the famous Thomas Ray study of psychedelic receptor affinity and played with the data and the non-negative least squares method in a Jupyter notebook for a bit. The first thing I tried was to create a compound like 2C-B but better. Under dubious- but not entirely random- assumptions, I set the desired receptor affinity to be that of 2C-B but with the following modifications: to have the 5HT2B affinity be as low as possible in order to minimize cardiotoxicity concerns, and borrow from MDMA’s unique profile the hypothesis that the Imidazoline receptor is related to heart-opening effects. Additionally, I modified the receptor profile so that the drug would give you more focus than 2C-B by having a higher affinity for the dopamine receptors. To top it off, I racked up the desired receptor affinity for 5HT7, as it has been implicated in providing the more utterly mind-blowing power of psychedelics. I entered these modifications into the NNLS optimizer and the output I got was**:
0.48*2C-B + 0.337*5-MeO-DMT + 0.116*MDMA + 0.043*cis-2a + 0.016*6-F-DMT + 0.005*Mescaline
I see, so since 2C-B is still the backbone of the desired affinity pattern, it appears in high proportion in the mixture as a kind of “base” on top of which the modifications are made. It makes sense that 5-MeO-DMT would come next as it is pretty selective for 5HT7 (remember, the most literally mind-blowing chemical), and MDMA would follow due to the desire for Imidazoline affinity. That by the way, is also probably partly why the formula contains a pinch of Mescaline, to round up that Imidazoline for good measure. I then decided to relax the 5HT7 requirement and instead increase the 5HT6 and 5HT5A, and got the following formula:
0.038*Lisuride + 0.273*2C-B + 0.056*DMT +0.079*Mescaline + 0.15*MDMA + 0.377*RR-2b + 0.018*Ibogaine
And this now looks pretty different. After playing like this for a while, it occurred to me to use this technique to basically try to reconstruct a drug using a non-negative linear combination of the remaining drugs available. Imagine for example that you are stuck in quarantine at your house and you don’t have any 2C-B to kill time (I know! Very relatable isn’t it?), but you do somehow happen to have an assortment of hundreds of other unscheduled random research chemicals. Could you combine them in such a way that you approximate the effects of 2C-B? Well, let’s see.
Here are the “drug reconstructions” the method derives (again, please, don’t try this at home):
I am pleasantly surprised to see the formulas actually do seem pretty intuitive to me. Take for example the DIPT reconstruction. The top two ingredients are 5-MeO-DIPT and DPT, which are the two closest structural analogues of DIPT in the dataset. Or take the one for DOB: this is the amphetamine version of 2C-B, so it makes sense that both an amphetamine psychedelic (Aleph-2) and 2C-B would make up the top two ingredients. Or consider 5-MeO-DMT, with its most prominent ingredient being 5-MeO-TMT, which is one carbon atom away in terms of structure. Or see how Mescaline’s heart-opening effects are well represented by its reconstruction with MDMA and MDA, while TMA contributes the receptor affinity characteristic of the trimethoxy class of functional groups, along with another Mescaline-like phenethylamine, 4C-T-2. Alas, here is where an imperfect understanding of drug interactions could come and bite us in the ass: if 4C-T-2 is anything like 2C-T-2, it might have some MAOI action, which could be potentially very dangerous to combine with compounds like MDMA. Needless to say, before you go out and try these crazy drug cocktails, we first need a thorough understanding of each drug well beyond just its affinity to “only” 30 or so receptors.
Now, not every reconstruction makes sense to me, and really only a few substances have what I would call a descent mean squared error. See the receptor affinity tables below for examples of both successful and unsuccessful reconstructions (only non-zero entries shown):
DOB and 2C-T-2 have some of the lowest errors in the sample, meaning that their reconstructions are pretty good, while Ibogaine and MDMA have two of the worst error rates, and their reconstructions are still obviously pretty far from the goal. Naturally, if we were ever to test this method in the lab (with e.g. a drug discrimination paradigm) we would probably start with the most accurate reconstructions first. For instance, train rats to distinguish between 2C-B and DOB, and see if administering the (2C-B-containing) “DOB reconstruction” makes the rats think they got DOB rather than 2C-B.
Master Druggist (Synapse? Dendrite?)
I would like to conclude this essay with an interesting speculation: what if we developed drug combos like we develop perfumes? It is my appreciation that it takes a very high level of intelligence, domain expertise, and psychological robustness to be able to contribute usefully to the field of psychonautics. Sasha Shulgin spent over 30 years taking hundreds of completely new drugs, and I would very much trust his judgement about what makes a great psychedelic drug combo than I would trust a random BlueLight or Erowid user. (As an aside: Shulgin was extremely cautious in his approach, but he certainly wasn’t doing some of the low-hanging fruit on safety, such as wearing a heart monitor or measuring his blood pressure when taking a new drug, for starters. Future systematic psychonautic work should also record as much biometric data as is feasible). You wouldn’t put on a perfume made by someone who has only ever worn Axe, would you? Training a “Nose” takes up to 7 years, and it involves becoming deeply familiar with the scent of a long list of molecules, accords, and perfumes. Likewise, I’d expect that in order to be qualified to find extremely good drug combinations, one would first need to become familiar with the effect of many different individual drugs, “natural drug accords” (e.g. peyote), and designed drug cocktails. Only once you have an intuitive sense of how e.g. the sigma receptor interacts with the 5HT1A receptor would I trust your judgement about adding a pinch of agmatine to your already convoluted mixture of 20 psychoactive substances. A Super-Shulgin Academy could train people to be professional drug cocktail makers (if perfumers are called “Noses” would we call Super-Shulgin certified cocktail makers “Dendrites”?). As discussed above, this assumes that we can do this safely, which I suspect will be possible once we map out the space of dangerous combinations and receptors we shouldn’t mess with to avoid side effects like cardiotoxicity (e.g. 5HT2B, 5HT3A, calcium channels, etc.).
You come to the master cocktail designer with a general concept for a new recreational drug, and they would come up with activity profiles that best evoke those feelings. The Dendrite would select from hundreds or thousands*** of pure chemicals and accords to create your unique cocktail. As is the case with Noses in the perfume industry, a Dendrite would tend to have a set of about one to two hundred “frequently used” compounds, and a dozen or so “signature” ones they’re deeply familiar with and that usually reveal who the Druggist is, if found in large proportions in the end product. Of course there would be “house favorites” (e.g. the classic “ambroxan bomb” of Dior fragrances for men) and chemical fads (e.g. the wide adoption of Iso E Super in 90s perfumes). Every year would come with a new season of amazing, safe, and uniquely interesting recreational drug cocktails.
In perfumery you find both natural and synthetic “accords”: “Violet reconstructions” attempt to emulate the smell of violet but in a much more long-lasting, storable, and versatile way. Good Dendrites would not only use “natural accords” such as “peyote” or “marijuana plant” but would also make their own, aided with computer models and datasets of trip reports along with their own first person experiences. In both perfumery and professional drug cocktail making we would study accords packed with combos of qualia-triggering chemicals, and a Dendrite could be known not only for making good final products, but for making excellent accords with predictable and desirable effects.
To finalize the analogy (and this article) we could also discuss the way in which perfumes feel “broad spectrum” thanks to being constructed by combining “top, heart, and base notes”. Roughly speaking, top notes tend to “feel higher frequency” (such as citric scents) while base notes tend to “feel low frequency” (such as woody scents), not unlike how a symphony will tend to combine sounds across the spectrum. The most interesting, voluptuous, and commercially viable combos would also probably have a broad spectrum of activity. They would be anxiolytic, exciting, relaxing, trippy, and empathogenic to various degrees all at once. They would combine fast, slow, and spiritual euphoria in a single power punch of qualia cornucopia. As such, each drug cocktail made this way would entail an entire worldview – a whole realm currently hidden in the vast state-space of consciousness.
* For an intuition: recall from linear algebra that a basis of n linearly independent vectors span an n-dimensional vector space. When the vector that you are trying to reconstruct is not in the span of your basis, the best you can do is to project your vector to the nearest hyperplane of the spanning space. Adding the constraint that you can only make non-negative linear combinations with your basis vectors, you find that the span will look like an ‘inverted pyramid’, and the least-squares solution will be the point of that inverted pyramid that is closest to your desired vector. This is why most of the reconstructions only use a subset of the available drugs in the dataset. In most cases, the desired vector (i.e. affinity profile in this case) will be outside of the inverted pyramid of the non-negative span, and the closest hyperplane will be a linear combination of only a subset of the building blocks- those which span that particular hyperplane. I.e. the solution is the projection to the nearest hyperplane segment covering the non-negative span. This is what the NNLS method is doing under the hood.
** Note: It’s important to point out that these are not dosages. The coefficients provided by the non-negative least squares method apply to the normalized affinity “npKi“, which is the receptor affinity normalized by the highest affinity among the receptors. The coefficients will be correlated with “proportion of a standard active dose” but there will be an error caused by the pretty tricky confounder that molecules vary in their “breadth of affinity”. Additionally: the psychoactivity of each receptor is not the same, we are not considering saturation effects, the difference between partial and full agonists is not taken into account, downstream effects are ignored, etc. etc. Needless to say, there is still quite some work to be done to transform these coefficients into meaningful dosages.
*** List of Psychoactive Drugs a professional Dendrite would be expected to be familiar with:
L-Tyrosine, L-DOPA, Apomorphine, Flumazenil, CPZ, BPAP, PPAP, Cabergoline, DAR-0100, Lisuride, Pergolide, Pramipexole, Rotigotine, Biopterin, PLP, Aminepetine, PCP, Marijuana, Dextromethorphan, Isoflavones, Citicoline, Metadoxine, Arecoline, Niacinamide, Paraxanthine, a-GPC, Acetylcarnitine, AR-R17779, GTS-21, Ispronidine, PHA-543,613, SSR-180,711, WAY-317,538, Hopantenic Acid, IDRA-21, Propentofylline, PRL-8-53, Trytophan, Picamilon, Betahistine, A-349,821, Cipoxifan, Creatine, Mildronate, Pregnenolone, Nisoxetine, Orexin, CP-39,332, Esreboxetine, Daledalin, AM-1248, Phenoxybenzamine, Symbescaline, Phentolamine, Isomescaline, Tolazoline, a-Methylfentanyl, Ketamine, Dichlorpane, 3-meo-pcp, Hex-en, Paraflourofentanyl, 3-Methylfentanyl, Metofoline, Buscaline, O-DT, Nortilidine, Thiobuscaline, Dizocilpine, Rolicyclidine, Phenescaline, Tenocyclidine, Methoxyketamine, pFPP, 5-me-MDA, 4-MAR, 1,4-Butanediol, 2-Methyl-2-Butynol, GHV, GVL, Mebroqualone, Benzylbutylbarbituates, Phenmetrazine, 3-Fluorophenmetrazine, Crack, Cocaine, Coca, Kava, Phenylacetylindoles, Benzoylindoles, Napthoylindoles, Adamantoyindoles, Pineapple Sage, Kokum, Brahmi, Artic Weed, Skullcap, Salvia Splendens, Coriander, Rhodiola Rosea, Velvet Bean, Bitter Orange, St. John’s Worth, Grape Seed Extract, Tulsi, Blessed Thistle, 3-Desoxy-MDA, Skatole, Isoindole, Indole, Benztropine, Diphenhydramine, Niaprazin, Doxylamine, Alaproclate, Zopiclone, Ifoxetine, Methylmethaqualone, Panuramine, Meta-Tyramine, Para-Tyramine, 2M2B, Pirandamine, SB-649,915, Epinephrine, Mepyramine, Octopamin, Delucemine, Oxidopamine, β-Methylphenethylamine, Mesembrine, Psuedoephedrine, Etolorex, Cathine, Cathinone, Ethcathinone, Norfenfluramine, Fenfluramine, Phentermine, Metaescaline, n-Ethylbuphedrone, Naphyrone, Pyrovalerone, Isopropylamphertamine, Clobenzorex, Pholedrine, Chlorphentermine, Xylopropamine, DON, DOPR, TMA, Methyl-BOB, Tetramethoxyamphetamine, 4-MTA, Bromatane, Hydroxyzine, BNC-210, CL-218,872, L-838,417, SL-651,498, S32212, 6-CAT, TAP, ETAI, IMP, Lorxaserin, Cisapride, Tegaserod, AS-19, E-55888, LP-12, LP-44, LP-211, Etoperidone, Lorpiprazole, Lubazodone, Mepiperazole, 5-TASB, TB, 3-TE, 4-TE, 2-TIM, 3-TIM, 4-TIM, 3-TM, 4-TM, TMA, TMA-2, TMA-3, TMA-4, TMA-5, TMA-6, 3-TME, 4-TME, 5-TME, 2T-MMDA-3a, 4T-MMDA-2, TMPEA, 2-TOET, 5-TOET, 2-TOM, 5-TOM, TOMSO, TP, TRIS, 3-TSB, 4-TSB, 3-T-TRIS, 4-T-TRIS, 44-BMAR, 3-MOMC, Prolintane, SDB-001, AB-FUBINACA, Dichloromethylphenidate, AB-PINACA, MN-24, 5F-MN25, A-836,339, ADBICA, 5F-NNEI, RCS-4, RCS-8, MPHP, 6-APDB, 4-HMP, EDMA, a-PBP, Methylhexamine, a-PPP, 4-FMD, EIDA, Phenylphrine, UWA-101, MPBP, RH-34, F-2, F-22, MR-2096, Adrenochrome, AET, Carbogen, DOB, DOM, Desmorphine, Ethylcathinone, Ehylene, GHV, Hypocretin, mCPP, MDPR, Methaqualone, TFMPP, CPP, MeoPP, A2, Salvinorin A, Scoplamine, TMA-2, BDO, 2c-B-FLY, 4-Flouromethcathinone, 4-HO-MPT, U4EA, 4-MTA, Phenylpiracetam, Aniracetam, Coluracetam, Pramiracetam, Melatonin, NRG-3, Theobromine, A834-735, Oxytocin, NZT-48, Heroine, 3-HO-PCP, MAOIs, 4-MeO-PCP, 3c-P, 5-IAI, Atropine, 5-IT, Bufotenin, 5-MAPB, 4-Aco-MiPT, 6-MAPB, ALD-52, AMMI, MET, D2PM, DET, CBD, CBN, LY-2183240, SF-SDB-005, AM-404, EG-018, DXM, FDU-PB22, AL-LAD, 3-MeOMC, 2-MeO-Diphenidine, 4-MPD, bk-MDMA, 4-MeO-a-PVP, GHB, 4-MeO-PBP, MBDB, 4-MeO-PV9, Fentanyl, 4F-PV8, a-PBT, BDB, a-PVT, 2-FMA, Dibutylone, 5-Meo-DiPT, Diclofensine, Methcathinone, DL-4662, MDEA, MDPPP, Methylone, Butylone, NEB, Phenibut, PV-8, GABA, 25B-NBF, Etaqualone, 5-API, Ethylone, Pentadrone, 4F-PVP, 25C-NBF, BZ-6378, C30-NBOMe, RH-34, MDAT, MDMA, MDMAI, Dimethocaine, Synthacaine, 3β-FBT, 5-MeO-BFE, 3,4-DMMC, AM-1248, MTTA, AM-2233, URB-597, AM-694, AM-087, BAY-38-7271, AB-005, A-796260, URB-754, 2-DPMP, a-PVP, 25N-NBOMe, 5-MeO-NiPT, Dexmethylphenidate, Buphedrone, RTI-111, Pentylone, 25I-NBF, Flourotropacocaine, Flourococaine, Cocaethylene, 25D-NBOMe, 25E-NBOMe, DMT, 5-Meo-DMT, 2C-I, 2C-E, 25I-NBOMe, 25I-NBOH, 25C-NBOMe, MXE, MDA, MDE, Mescaline, Ibogaine, Bromo-DragonFLY, Salvinorum, RU-28306, 2NE1, Psilocybin, HOT-7, JWH-018, JWH-250, 5-Meo-EiPT, AM-2201, 5-APDI, BZP, BZ, 4-MEC, MDPV, Bakers Ammonia, THC, THCv, Chloral, Chlorabutynol, MT-45, 5-Methyl-Ethylone, Methylphenidate, Ethylphenidate, 6-APB, 5-APB, Muscimol, 5-MeO-MALT, AKB48, 3,4-CTMP, PB-22, Diphenidine, UR-144, Flubromazepam, HU-210, MPA, XLR-11, MN-18, Naltrexone, STS-135, Gabapentin, 5-MAPB, Nitrous, Etizolam, Mephedrone, Pyrazolam, Methedrone, AH-7921, Phenazepam, AMT, OxyNEO, DPT, 5-MeO-AET, 4-Aco-DMT, EAM-2201, 5-MeO-DALT, 5-MeO-AMT, Acefentanyl, Ehylphenidate, 4-HO-MiPT, THJ-2201, 5-APDB, 5-EAPB, 4-HO-DPT, DOC, bk-2c-B, Escaline, THJ-018, 4-HO-MET, 2-AI, 2-MeO-Ketamine, Methoxphenidine, Ketamine, 2c-EF, Methamphetamine, Dextroamphetamine, Nitracaine, DALT, IAP, 4-fa, 2-Me-DMT, 4-fcocaine, Isopropyl Nitrate, 5-MeO-TMT, Piracetam, Amatadine, Choline, Memantine, 5-HTP, Camfetamine, Methallyescaline, LSZ, LSA, NBOMe-Mescaline, Loperamide, LSB, 25P-NBOMe, 25G-NBOMe, 3-MeO-PCE, MAM-2201, PCP, MPTP, MDAI, DOI, BB-22, EA-3167, BDF, L-Theanine, Dimethylone, Hydrocodone, Codeine, Morphine, Dilaudid, Oxycontin, Alpralozam, Diazepam, Fentanyl, Soma, Suboxone, Marinol, Seroquell, Trazodone, Lithium Bicarbonate, Abilify, Methadone, Amitriptyline, Strattera, Chloral Hydrate, Bromazepam, Buperonorphrine, Bupropion, Chlordiazepoxide, Clonidine,Clonazepam, Cyclobenzaprine, Dramamine, Benadryl, Ethchlorvynol, Fluoxetine, Tianeptine, Amineptine, Flurazepam, Metaxalone, Mirtazapine, Nalaxone, Nimetazepam, Oxymorphone, Paroxetine, Zopidone, Pregabalin, Promethazine, Risperadone, Selegiline, Sertraline, Sumatripan, Tiagabine, Propofol, Propanolol, Tiletamine, Zolpidem, Lotus, Aloe, Datura, Calendula, Chacruna, Galangal, Chaliponga, Chamomile, Damiana, Fever Few, Nightshade, Ginseng, Foxglove, Lavender, Henbane, Mugwort, Hemlock, Monkshood, Dream Herb, Capsaicin, Amanita, Hawaiian Baby Woodrose, Ergot, Hops, Imphepho, Indian Warrior, Kanna, Dagga, Kratom, Mandrake, Valerian, Nicotiana Tobacum, Nicotiana Rustica, Mimosa Hostilis, Morning Glory, Nutmeg, Opium Lettuce, Poppy, Sinicuichi, Syrian Rue, Tree Tobacco, Wormwood, Yohimbe, Yopo, Khat, Peyote, Cannabis, Catnip, Phalaris, San Pedro, Soma (ancient), Chacruna, Acacia, Ephedra, Mulungu, Mullet Fish, Siganus Spinus, Fugu, Sting-ray Venom, Bufo Alvarius, Epipedobates Tricolor, Waxy Monkey Frog, Salamandra Salamandra, Cobra & Scorpion Venom, Reindeer Urine, Glomeris Marginata, Sergeant Major, Grouper, Bluefish, Brass Beam, Flathead Mullet, Golden Goatfish, Rabbit Fish, Goat Fish, Adrafinil, DHEA, Dilantin, DMAE, Fipexide, Gerovital, Ginko, Black seed oil, HGH, Hydeigine, Meclofenoxate, Modafinil, Oxiracetam, Phenyton, Vasopressin, Vinopocetine, Bee Venom, Monkey Frog, UCM-707, AM-1172, VDM-11, VDM-13, OMDM1, OMDM2, LY-2318912, O-2093, OL-135, URB-597, URB-532, AEM, AL, ALEPH, ALEPH-2, ALEPH-4, ALEPH-6, ALEPH-7, ARIANDE, ASB, B, BEATRICE, BIS-TOM, BOB, BOH, BOHD, BOM, 4-Br-3,5-DMA, 3-Br-4,5-MDA, 2C-B, 3C-BZ, 2C-C, 2C-D, 3C-E, 2C-F, 2C-G, 2C-G-3, 2C-G-4, 2C-G-5, 2C-G-N, 2C-H, 2C-N, 2C-O-4, 2C-P, CPM, 2C-SE, 2C-T, 2C-T-4, 2C-T-2, 2C-T-7, Ψ-2C-T-4, 2C-T-8, 2C-T-9, 2C-T-13, 2C-T-15, 2C-T-17, 2C-T-21, 4-D, β-D, DESOXY, 2,4-DMA, 2,5-DMA, 3,4-DMA, DMCPA, DMMDA, DMMDA-2, DMPEA, DOAM, DOBU, DOEF, DOET, Ψ-DOM, DON, DOPR, E, EEE, EEM, EME, EMM, ETHYL-J, ETHYL-K, FLEA, G-3, G-4, G-5, GANESHA, G-N, HOT-2, HOT-17, IDNNA, IM, IP, IRIS, J, LOPHOPHINE, M, 4-MA, MADAM-6, MAL, MDAL, MDBU, MDBZ, MDCPM, MDDM, MDHOET, MDIP, MDMC, MDMEO, MDMEOET, MDMP, MDOH, MDPEA, MDPH, MDPL, MDPR, ME, MEDA, MEE, MEM, MEPEA, META-DOB, META-DOT, METHYL-DMA, METHYL-DOB, METHYL-J, METHYL-K, METHYL-MA, METHYL-MMDA-2, MMDA, MMDA-2, MMDA-3a, MMDA-3b, MP, MME, MPM, ORTHO-DOT, P, PE, PEA, PROPYNYL, SB, TA, 3-TASB, 4-TASB, Tropane, Vomeronasal Organ, Tropine, Hyosyamin, Dihydrokavain, Hyoscine, Myrcene, Ecgonine, 7-OH-DPAT, Benzoylecgonine, Sunifiram, Hydroxytropacocaine, Estrogen, Methylegonine Cinnamate, Estradiol, Catuabines, Estratetraenol, Phenyltropane, Androstenone, Civetone, Adrostenol, 5F-PB-22, Androstadienone, CBG, THCa, CBC, CBDa, Anandamide, 2-AG, CBL, CBDv, CBCv, CBGv, CBGm, Ibogaine, Noribogaine, Tabernanthine, Coronaridine, Ibogamine, Vaocangine, 18-MC, 5-MeO-Alkyltryptamine, β-Carboline, Tryptoline, Pinoline, Harmane, Harmaline, Harmine, Harmalol, Harmalan, Harmanamide, Acetylnorhormine, Bufotenin Oxide, DMT-N-Oxide, 5-MeO-Tryptamine, 5-OH-DMT, 5-MeO-DMT-Oxide, 3,4-Dimethoxyphenylamine, 6-MeO-Harman, Anethole, Safrole, Estragole, Monolignol, Pukateine, Glaucine, THP, Nantenine, Thujone, Lagochilin, Nicotine, Carbachol, Methacholine, ME-18-MC, 18-MAC, Tryptamine, β-Methyl-Phenethylamine, NMT, Voacanga Africana, Vachellia Farnesiana, Duboisia Hopwood, Acacia Victoriae, Anadenanthera Penegrina, Phalaris Aquatica, Echinopsis Lageniformus, Cylindropuntia Echinocarpa, Leptactina Densiflora, Fennel, Justica Pectoralis, Lactucarium, Glacium Flavum, Zornia Latifolia, Argemone Mexicana, Silene Undulata, Catharanthus Roseus, Desfontainia, Heimia Salicifolia, Lophophora, Sea Urchin Eggs, Bethanechol, Muscarine, Pilocarpine, Oxotremorine, Aporphine, Leonurine, Bungacotoxin, Tetrodotoxin, Taurine, Opiod Peptide, Streamlined Spinefoot, Blue-Spotted Spinefoot, Dusky Spinefoot, Marbled Spinefoot, Little Spinefoot, Salema, Phyllomedusa, Blue Sea Chub, Brow Chub, Conuict Surgeonfish, Yellowstipe Goatfish, Finstripe Goatfish, Acute Jawed Mullet, Coral Grouper, Platypus Venom, Slow Ioris Venom, Pygmy Slow Ioris Venom, Giant Leaf Frog, Gluten Exorphin, Soymorphin-5, Dermophin, 7-PET, Dimethyliambutene, Proopiomelanocortin, β-Endorphine, Dynorphin, Adrenorphin, Salvinorin B Methoxymethyl ether, Amindophin, Enkephalins, Salvinorin B ethoxymethyl ether, Opiorphin, Herkinorin, RB-101, DPI-221, Spinorphin, Kelatorphan, Delta-Pheylalanine, Thiorphan, Tynorphin, Hemorphon-4, Valorphin, Casomorphin, Gliadorphin, Rubiscolin, Deltorphin, MG6, MT-45, Myrophine, Acetorphine, Acetylmorphone, Actiq, Benzethidine, BU-48, BRL-52537, Pethidine, Naloxol, Betacetylmethadol, Methorphan, Bezitramide, RAM-378, Bromadol, Eriadoline, BW373U86, Thebaine, C-8813, Menthol, 8-CAC, Capperidine, Matrine, Chloromorphide, a-Chlorocodide, HZ-2, Codeinone, LPK-26, Codoxime, AD-1211, Conorfone, DADLE, Butorphanol, DAMGO, Semorphone, Dextromoramide, Sutentanil, Diampromide, Zenazocine, Difenoxin, Thebacon, Dihydroetorphine, Tilidene, Dimenoxadol, Xorphanol, Dipipanone, Dipropanoylmorphine, Doxpicomine, DPI-3290, Drotebanol, Endomorphin, Eseroline, Ethoheptacine, 14-Ethoxymetopon, Ethylmorphine, Etorphine, Etoxerdine, Furethidine, Heterocodeine, RAM-320, IBNtxA, IC-26, 1-Iodomorphine, Isomethadone, Ketobemidone, Ketorfanol, Lefetamine, Levorphanol, Loperamide, Meprodine, Metofoline, Metopon, Morpheridine, Morphine-N-Oxide, Morphinone, MR-2096, Nicocodeine, Nicomorphine, Normethadone, Ocefentanyl, Ohmefentanyl, Oxpheneridine, Oxymorphazone, Oxymorphol, Oxymorphone, Pentamorphone, PEPAP, Pericine, Phenadoxone, Phenempromide, Phenazocine, Pheneridrine, Phenomorphan, Picenadol, Piminodine, Piritramide, Proclilidine, Prodine, Proheptazine, Properidine, Prosidol, R-30490, R-4066, Ro4-1539, RWJ-394674, Sameridine, SC-17599, Methyldesorphine, Hydroxypethidine, 4-Fluouropethidine, Cannabis Indica, Cannabis Sativa, Cubensis, Hash, BHO, Delta-9-THC, 25TFM-NBOMe, 2C-B-BZP, 2CBFLY-NBOMe, 2CD-5Et0, 5-I-R91150, A-372,159, 2-Bromo-LSD, a-5IA, PWZ-029, L-655,708, TB-21007, 5-Ethoxy-DMT, 5-Ethyl-DMT, 7,N,N-TMT, VER-3323, YM-348, Alnespirone, 8-OH-DPAT, Aminorex, Batoprazine, 5-BT, BIMU-8, BMY-14802, BRL-54443, BW-723C86, 5-CT, CGS-12066A, Cinitapride, CJ-033,466, CP-135,807, CP-809,101, CP-93,129, CP-94,253, N,a,-DEPEA, Dimemebfe, RA-7, E-6801, E-6837, Eltoprazine, Methylsulfonylmethane, EMD-386,088, EMDT, ST-1936, Fluprazine, Indorenate, Jimscaline, L-694,247, Lasmiditan, APD-356, MMDPEA, LY-293,284, LY-310,762, LSD-pip, LPD-824, LSM-775, 5-MT, MBZP, Methyl-MMDA-2, a-MS, MK-212, Mosapride, Org 12,962, Org 37,684, Quipazine, 6-Nitroquipazine, NBUMP, 1-NP, 5-(Nonyloxy)Tryptamine, PHA-57378, PNU-181731, PNU-22394, Propylhexedrine, Prucalopride, PRX-03140, Psilocin, RDS-127, RH-34, Ro60-0175, Ro60-0213, RS-56812, RS-67,333, RU-24,969, RU-28306, SKF-97,541, SR-57227, Tandospirone, Tegaserod, TFMFly, pTMFPP, U-92,016A, SCA-136, TD-5108, Vortionetine, WAY-161503, WAY-208,466, WAY-629, Xaliproden, YM-31636, Zacopride, A-423,579, A-84,543, Abercarnil, 5-Br-DMT, Sugar, Acetildenafil AMMI 4C-D, AS-8112, Astemizole, Asymbescaline, Azapride, BAY-38-7271, BAY-59-3074, BAY-60-6583, Benproperine, Benzylmorphine, Berberine, 2-Pyrrolidone, JBIR-03(1), 1′-O-Acetylpaxilline, Penijanthine A, Emindole DA (1), Petromindole, Emindole SA (2), JWH-133, Napthylmethylindoles, Napthyolpyrroles, Napthylideneindenes, Cyclohexylphenols, Indole-2-Carboxamides, C3 Amino-Indoles, Cymserine, Hodgkinsine, Physostigmine, Psychotridine, Psychotria Colrata, Yuremamine, Gevotroline, Latrepirdine, BMY-7,378, Boldine, BP-897, Brexpiprazole, 4-Bromo-3,5-Dimethoxyamphetamine, Bromopride, Caroverine, CGS-20625, Cinchocaine, DAA-1097, DAA-1106, DOTFM, DMPEA, DMCM, Dyclonine, Ethylvanilin, Evoxine, Furoquinoline Alkaloids, Gabazine, GBLD-345, Rapacuronium, Mivacurium Chloride, Cisatracurium Besilate, DTC, Cloroqualone, Diproqualone, Mecloqualone, Methylmethaqualone, Eszopiclone, TP-003, TP-13, TPA-023, Y-23684, Pagoclone, Pazinaclone, Suproclone, Suriclone, Zapiclone, CGS-9896, NS-2664, NS-2710, Pipequaline, RWJ-51204, SB-205,384, ELB-139, Acamprosate, GABOB, N4-Chloroacetylcytosine Arabinoside, (+)-CAMP, CACA, AZD-3355, 1,4-Butanediol, XP19986, Rosarin, Rosavarin, Atagabalin, Gabapentin Enacarbit, Hopantenic Acid, Imagabalin, 4-Methylpregabalin, PD-217,014, Afloqualone, Rocuronium Bromide, Vecuronium Bromide, Pipecuronium Bromide, Pancuronium Bromide, Amyl Nitrate, Atracurium Besilate, BWA444, Benzylisoqualone, Papaverine, Protopine, HS-342, HS-347, HS-310, Emylcamate, Eperisone, Febarbamate, Flavoxate, Inaperisone, Acamprosate, Progabide, Tiagabine, Lanperisone, Mephenesin, HS-692, HS-693, HS-704, HS-705, HS-626, Chlorzoxazone, Cisatracurium Besilate, Curare, Cyclobenzapine, Dantrolene, Decamethonium, Difebarbamate, Dihydrochanclonium, Doxacurium Chloride, Gallamine Triethiodide, Gantacurium Chloride, Hexafluronium Bromide, Meprobamate, Metaxalone, Methocarbamol, Norgesic, Orphenadrine, Pancuronium Bromide, Phenprobamate, Pipecuronium Bromide, Premazepam, Promoxolane, Quazepam, Rocuronium Bromide, Silperisone, Sulazepam, Suxamethonium Chloride, Suxethonium Chloride, Tetrabamate, Tizanidine, Tolperisone, Gigantine, BAY-73-6691, Indiplon, Nitrosoprodenafill, Zaleplon, Udenafil, Sulfoaildenafill, Sildenafil, Ocinaplon, Alpidem, Bamaluzole, DS-1, Fadrozole, Fazadinium Bromide, Imidazopyridine, Minodronic Acid, Bisphosphonate, Miroprofen, Necopidem, AL-LAD, DBT, a.O-DMS, 2,a-DMT, a,N-DMT, ETH-LAD, a-ET, 4-HO-DBT, 4-HO-pyr-T, MBT, 4,5-MDO-DIPT, 5,6-MDO-DIPT, 4,5-MDO-DMT, 5,6-MDO-DMT, 5,6-MDO-MIPT, 5,6-MeO-MIPT, 5-MeO-pyr-T, 5-MeO-NMT, 6-MeO-THH, 5-MeS-DMT, PRO-LAD, pyr-T, a,N,O-TMS, Olprinone, Telcagepant, Febrifugine, Halofuginone, MK-0249, LY-156,735, Ramelteon, Tasimelteon, SL-164, Quinazoline, Albaconazole, Altaserin, ATC-0175, Canertinib, Cediranib, Doxazosin, Fluproquazone, Gefitinib, Katanserin, Lapatinib, Agmatine, Amantadine, AP-7, AP5, Aptiganel, CGP-37849, 7-CTKA, DCKA, DXO, MK-801, SL-82.0715, Esketamine, Ethanol, NEFA, Besonprodil, Gacyclidine, Gavestinel, Huperzine A, Ifenprodil, Indantadol, Metaphit, Memantine, LY-235,959, Lubeluzole, Levomethadone, Kynuretic Acid, Midafotel, Neramexane, Nitromemantine, PEAQX, Perzinfotel, 8A-PHDQ, Remacemide, Rhynchophylline, Sabeluzole, Tiletamine, Tramadol, Xenon, Hydroxchloroquine, Antrafenine, Bedaquiline, GSK-299423, JTC-801, JTE-907, LGD-2226, PBT-2, PF-2545920, SB-215,505, SB-277,011-A, SB-742,457, BHF-177, BHFF, BSPP, Cartazolate, CGP-7930, Clomethiazole, Etazolate, Etomidate, Felbamate, Fospropofol, Gaboxadol, Glutethimide, GS-39783, Ibotenic Acid, ICI-190,622, Isoguracine, Isonipecotic Acid, Loreclezole, Methyprylone, Allopregnanolone, 5a-Dihydroprogesterone, Progesterone, THDOC, Alfadolone, Alfaxalone, Ganaxolone, Hydroxydione, Minaxolone, Org-20599, Pregnane, Piperadone, Propanidid, Propofol, Pyrithyldione, ROD-188, Stiripentol, Thiomuscimol, Thymol, Tybamate, QNB (BZ), Scopolamine, Midazolam, Sodium Pentathol, Amobarbital, Blue 88, Adinazolam, Alphenal, Bentazepam, Bromisoval, Camazepam, Carbromal, Centalun, Chloralodol, Chronobiotic, Cinolazepam, Clorazepate, Cloxazolam, Cyclopyrrolones, Delorazepam, Dichloralphenazone, DPH, Doxefazepam, Doxylamine, Embutramide, Eplivaserin, Ethinamate, Ethyl Ioflazepate, Fludiazipam, Heptabarb, Oleamide, Org 21465, Org 25435, Paraldehyde, Phenobarbital, Propiomazine, Promethazine, Propylbarbital, QH-II-66, Glycine, Quetiapine, SH-053-R-CH3-2’F, Sulfonmethane, Tetrabarbital, Tetronal, Trional, Trytophol, Acaprazine, Acebrochal, Acetylglycinamide Chloral, Almorexant, Detomidine, Bromouriede, Benzoctamine, Barakol, Bekhterev’s Mixture, Fasiplon, Fenadiazole, Fluperlapine, JM-1232, Inebriating Mint, Ro41-3696, Methapyrilene, Minitran, Nisobamate, Oxanamide, Oxomemazine, Panadiplon, Pazinaclone, Pentabamate, Petrichloral, Potassium Bromide, Procymate, Saripidem, Vinybital, Vinbarbital, Valofane, Validolum, Valeric Acid, Unisom, U-90042, U-89843A, Triclofos, 2,2,2-Trichloroethanol, TCS-OX2-29, SX-3228, Suvorexant, Sigmodal, SB-649,868, 6-APA, 77-LH-28-1, Adimolol, Alfentanil, Amedanil, Amedalin, BMS-564,929, Binospirone, Carburazepam, Clazolam, Clobazam, Clobenzepam, Clotiazepam, Thienodiazepine, Brotizolam, CP-14145, Cyclazodone, CSP-2503, Cycloserine, Cytisine, Demoxepam, Chlordizepoxide, Dibenzepin, Dihydroergocorine, Dihydroergocristine, DHEC, Dihydroergotamine, 17-DMAG, Dimiracetam, Doliracetam, Droperidol, Dihydrotestosterone, Dutasteride, Edaravone, EGIS-12,233, Elfazepam, Elzasonan, Enilospirone, Ergoloid, Ergotamine, Ergocrytine, Ergocristine, Ergovaline, Etazepine, Evodiamine, Fenmetramide, Fenozolone, Flunitrazepam, Flutazolam, Flutemazepam, Flutoprazepam, Fosazepam, GW-803,430, Halazepam, Haloxazolam, Herbimycin, Horsfiline, HT-0712, Icilin, Clazepam, Indoprofen, Ipsapirone, Isatin, Ketazolam, KF-26777, Lofendazepam, Lopirazepam, Loprazolam, Lorazepam, Lormetazepam, Menitrazepam, Meclonazepam, Menitrazepam, NMSP, Mexazolam, THCI, THCII, THCIII, THCIV, THCV, Mosapramine, Motrazepam, NBQX, Nevirapine, Nimetazepam, Nitrazepam, Nitrazepate, Nitroxazepine, Nordazepam, Nortetrazepam, Oxazepam, Oxatomide, Paliperidone, Prazepam, Pivoxazepam, Pirquinozol, Pirenzepine, Pinazepam, Pemoline, Paraxazone, Palonosterone, Proflazepam, Propizepine, Razobazam, Revospirone, Ripazepam, Ro15-4513, Ro48-6791, Ro48-8684, Ro5-2904, Ro5-4864, Ro64-6198, Ropinirole, RPL-554, RS-102,221, SL65.0155, Spiroxatrine, Temazepam, Tetrazepam, Thozalinone, Tolufazepam, Triflubazam, Vardenafil, Ziprasidone, Zolazepam, Zomebazam, Zometapine, Pyrazolodiazipines, Triazolodiazipines, Estazolam, Flubromazolam, Triazolam, Nitrobenzodiazepines, Pentazocine, 8-HO-PBZI, A-366,833, ABT-202, Sympathomimethies, ABT-239, ABT-418, Almotriptan, BD-1008, LR-132, BD-1031, Singma Agonists, BD-1018, 4-PPBP, Alazocine, BD-1052, Butinoline, Clemizole, CPHPC, Desoxy-D2PM, Citalopram, Ditolyguanidine, Escitalopram, Fluoxetine, Fluvoxamine, Tgmesine, L-697,384, PRE-084, S33005, SA-4503. Siramesine, Venlafaxine, Clonidine, VUT-8430, UR-AK49, Moroxydine, Altinicline, Anabasine, 3-Bromocytine, Bradanicline, Cotinine, Desformylflustrabromine, Dianicline, DMPP, Epibatidine, Epiboxidine, Lobeline, Myosmine, PNU-120,596, PNU-282,987, ABT-089,Rivanicline, RJR-2429, Phantasmidine, Sazetidine A, SIB-1553A, TC-1698, TC-1827, TC-2216, Tebanicline, 2,3,4,5-Tetrahydro-1,5-Methano-1H-3-Benzazepine, UB-165, Varenicline, FE-β-CPPIT, FB-β-CPPIT, RTI-336, NVP-AUY922, Pleconaril, RTI-177, RTI-371, Calea Ternifolia, African Dream Herb, Ambutonium Bromide, Hyoscamine, Ilex Guayusa, Abediterol, Aclidinium Bromide, Benzilycholine Mustard, Bevonium, Bornaprine, Cyanodothiepin, Darifenacin, Dexetimide, Dicycloverine, Etybenzatropine, Fenpiverinium, Fesoterodine, Homatropine, Hydroxyzine, Imidafenacin, Ipratropium Bromide, Methylatropine, Methylhomatropine, Octatropine Methylbromide, PD-0298029, PD-102,807, Pipenzolate, Piperidolate, Tiotropium Bromide, Anisodine, Benacytazine, Butylscopolamine, CAR-226,086, CAR-301,060, CAR-301,196, Caramiphen, Clidinium Bromide, Ditran, EA-3167, EA-3443, EA-3580, EA-3834, JB-318, JB-336, Methylscoplamin Bromide, Oxapium Iodide, Oxitropium Bromide, Polyfothine, Propiverine, Pyrrobutamine, Timepidium Bromide, Tridihexethyl, Tropatepine, WIN-2299, Amrutanjan, Abstral, Acetylmethadol, Acetyldihydrocodeine, Alletorphine, Anilopam, Axomadol, BC Powder, Befiradol, Benorilate, Betamethadol, Bicifadine, Butinazocine, Carbazocine, Celadrin, Chlorodyne, Cinchophen, Co-dydramol, Co-codamal, Cogazocine, Conolidine, Deltorphin I, Dezocine, Dimepheptanol, Dipyrocetyl, TRPV1 Receptor, Capsazepine, Dosulepin, Electroanalgesia, Epideral Steroid Injection, Eptazocine, Equianalgesic, Efazocine, Fedotozine, Filenadol, Fioricet, Fiorinal, Frakefamide, Hemprenorphine, 3-HM, Ibazocine, Levallorphan, Levomepromazine, Lufuradom, Magnesium Salicylate, Blue Prickly Poppy, Menabitan, A-40174, Dimethylhepylpyran, Metamizole, Metkefamide, Moramide, Morphiceptin, Moxazocine, Nafoxadol, Malmexone, Naproxen, Nefopam, Nimesulide, Naracymethadol, Norlevorphanol, Norpipanone, NS-11394, Panadol, Penthox Inhaler, Phenacetin, Phenazone, Phenazopyridine, Propyphenazone, Proxorphan, Resiniferatoxin, Rimazolium, Romifidine, RUB-A535, Salecylamide, Salonpas, Tectin, Tolfenamic Acid, Tenazocine, Ufenamate, Volazocine, Xylazine, Yangonin, Zinda Tilismath, Ziconotide, Anazocine, Bremazocine, Cyclazocine, EKC, Fluorophen, Gemazocine, Ketazocine, Metazocine, Quadazocine, Azocine, Benzazocine, 0-2545, DOU-216,303, Phenylethylpyrrolidine, GR-89696, HA-966, ICI-199,441, ICI-204,448, NNN, Nornicotine, Clemastine, PF-03654746, RTI-229, SB-269,970, U-50488, U-69,593, Bombesin, Bivaracetam, Cebaracetam, DEABL, Cromakalim, Doxapram, Dupracetam, Etiracetam, Fasoracetam, Imuracetam, Levetiracetam, Lidanserin, Nebracetam, Nefiracetam, Nicoracetam, Oxiracetam, Piperacetam, Seletracetam, MOPPP, MPBP, MPHP, MDPDP, MDPPP, Pyrovalone, a-PBP, a-PPP, Neuropeptides, Galanin, Neuropeptide Y, Enkephalin, Somatoslatin, CCK, Substance P, Neurotensin, TRH, Acepramazine, Aceprometazine, Acetanisol, Acetohexamide, Acetophenazine, Acetophenone, Acetosyringoine, 2-Acetylpyridine, Adrenalone, Anthrone, Apocynin, Avobenzone, Benzbromarone, Benziodarone, Benzoin, Butaperazine, CB-13, AM-6545, AZ-11713908, WIN-54,461, JWH-200, WIN-56,098,S-796,260, AM-1220, AM-1221, AM-1241, AM-2233, AM-630, AAI’s, CPE, GW-405,833, JWH-193, JWH-198, JWH-007, 3-Acetyl-6-Methoxybenzaldehyde, Aflobazole, AR-A000002, Azasestron, Bazinaprine, 3-Benzhydrylmorpholine, BML-190, Cobicistat, CYT387, Desmethylmoramide, Dioxaphetyl Butyrate, Edivoxetine, Epelsiban, Demoxytocin, Carbetocine, WAY-267,464, Atosiban, Eprobemide, L-371,257, L-368,899, Quinagolide, Terbutaline, 2CB-ind, 5-APDI, APICA, Donepezil, ICI-118,551, Indatraline, Indinavir, Ladostigil, Mutisianthol, PNU-99,194, S-15535, TAI, Zicronapine, Aleglitazar, Thromboxame Receptor Agonist, Verruculogen, Brevianamide, 2,5-DKP, Fellutanine, Phenylahistine, Plinabulin, Rugulosuvine, Fedrilate, Fenbutrazate, L-733,060, G-130, HC3, Indeloxazine, Levomoramide, Metostilenol, Molindone, Molracetam, Nimorazole, O-1057, O-1812, AM-2232, O-774, AM-2389, HHC, HU-243, Canbisol, Nabilone, 11-OH-THC, 2-AGE, Paxahexyl, THC-C4, AMG-36, AMG-41, AM-1235, AM-906, AM-365, O-2694, O-2372, O-2113, O-2050, VCHSR, TM-38837, PiplSB, PF-514273, MK-9470, LY-320,135, O-2545, PD-128,907, PF-219,061, ABT-670, ABT-742, UK-414,495, OSU-6162, Melanotan II, Oxaflozane, PF-592,379, 2-Phenyl-3,6-Dimethylmorpholine, Pramocaine, SCH-50911, 4-HTMPIPO, A-41988, AB-001, AB-005, ADBICA, AM-087, AM-411, KM-233, AM-679, AM-694, AM-855, AM-905, AM-919, AM-4030, AM-938, AM-251, AMG-1, AR-231,453, PSN-375,963, PSN-632,408, (C6)-CP-47,497, CCH, O-1871, CP-55,940, CP-47,497, CP-50,556’1, CP-55,244, Otenabant, (C9)-CP-47,497, CBS-0550, AVE-1625, GW-842,166x, HU-308, HU-336, HU-331, HU-320, Ajulemic Acid, JTE-7-31, A-834,735, MDA-19, S-444,823, JTE-907, JWH-015, JWH-019, JWH-030, JWH-047, JWH-048, JWH-051, JWH-057, JWH-081, SLV319, 2-Isopropyl-5-Methyl-1-(2,6-dihydroxy-4-nonphenyl)cyclohex-1-ene, HU-345, JWH-098, JWH-116, JWH-120, JWH-122, JWH-147, JWH-148, JWH-149, JWH-161, JWH-164, JWH-167, JWH-175, JWH-176, JWH-184, JWH-185, JWH-196, JWH-203, JWH-249, JWH-302, JWH-307, JWH-359, JWH-398, JWH-424, L-759,633, L-759,656, GW-405,833, Leelamine, NESS-0327, NESS-040C5, NMP-7, Nonabine, O-1125, O-1238, O-1269, O-806, O0823, Org-27569, Org-28312, LBP-1, Org-28611, Otenabant, Perrottetinene, PF-03550096, RCS-4, RCS-8, Rosonbrant, SDB-001, SDB-006, SER-601, Serinolamide A, THC-O-Phosphate, Tinabinol, VDM-11, Virohamine, A77636, Adafenoxate, Adapromine, Adatanserin, Bolmantalate, Bromantane, SR-142,948, 25B-NBOMe, 25I-NBMB, 25TFM-NBOMe, 5-MeO-NBpBiT, 2CBCB-NBOMe, 25CN-NBOH, Juncosamine, TCB-2, 6-Br-APB, Agelferin, Cridazepam, Meta-DOB, NGD-4715, Nicergoline, P7C3, SB-357,134, Sclerotia Truffle, 5-Flouro-aMT, 6-Flouro-aMT, Telepathine, AMDA, Amperozide, Cinaserin, Deramciclane, Fenanserin, Flibanserin, Glemanserin, Iferanserin, KML-010, LY-367,265, Pruvanserin, Rauwolscine, Setoperone, Spiperone, Volinanserin, Xlamidine, Altropane, ATI-2042, PIA, RTI-121, RTI-353, Tramethinib, SB-258,585, Lu-AE58054, MS-245, Ro04-6790, SB-271,046, SB-399,885, RTI-55, AC-262,356, 2′-Acetoxycocaine, Bemestron, Benzoylthiomethylecogine, Brasofesine, 2-CMT, Clobenztropine, Cocaethylene, Deptropine, Dichloropane, Diflouropine, Granisetron, 3-(p-Flourobenzoyloxy)tropane, p-ISOCOC, Methylvanillylecogonine, Norcocaine, NS-2359, RTI-126, WF-23, WF-33, WF-31, WF-11, BRL-46470, RTI-112, RTI-113, RTI-120, RTI-150, RTI-171, RTI-274, RTI-31, RTI-32, RTI-51, RTI-83, Thiophenyltropanes, MAT Inhibitor, Salicylmethylecgonine, Tesofesine, Troparil, WIN-35428, Amfonelic Acid, Oxolinc Acid, Tropisetron, Zatosetron, Dichloropane, RTI-336, RTI-126, Tropoxane, Poyo (Palm Wine), Tropicamide, Caffetin, Formic acid, Monocled Cobra, Sisa, Tramadol, Dazopride, Dolasetron, Amylocaine, Articaine, Bupivacaine, Butacaine, Chloroprocaine, Cyclomethycaine, Etidocaine, Hexylcaine, Levobupivacaine, Mepivacaine, Meprylcaine, Prilocaine, Proxymetacaine, Risocaine, Ropivacaine, Tetracaine, Trimecaine, Piperocaine, Metabutoxycaine, Adipiplon, Almitrine, ARRY-520, AZD5423, Cisapride, CP-226,269, CRL-40,941, DBL-583, Dexamethasone, DFMD, Methyldopa, Carbidopa, d-DOPA, L-DOPS, Octaflourocyclobutane, DFB, Didesmethylcitalopram, Elopiprazole, Phenylpiprazine, F-15,599, FGIN-127, Fletazepam, Flucindole, GR-159,897, LY-503,430, MPPF, PEPA, RS-127,445, S-23, SHA-68, SNAP-7941, SNAP-94847, TP-003, TPA-023, UH-301, Calycosin, Flavinoids, Psi-Tectorigenin, Blochanin A, Formononetin, Glyciten, Irigenin, Methoxyisoflavone, 5-O-Methylgenistein, 7-O-Methylluteone, Ononin, Pratensein, Prunetin, Retusin, Tectoridin, Tectorigenin, Barbigerone, Daidzein, Derrubone, Genistein, Ipriflavone, Irilone, Luteone, Orobol, Psuedobaotigenin, Wighteone, AMG-3, Nabazenil, Naboctate, a-Napthoflavone, 11-Nor-9-Carboxy-THC, Pirnabine, Apiol, Dillapiol, 1,3-Benzodioxole, Piperonal, beta-Asarone, Eleicin, Homovanyllyl Alcohol, Myristicin, 2-Bromo-4,5-Methylenedioxyamphetamine, Californidine, Chavicine, Cinoxacin, Dibutylone, Fenoverine, Befuraline, MDIP, MDMAI, MDPR, MDAL, ORTHO-MDA, MDP1P, MDP2P, Omiloxetine, Osemozotan, Piclozotan, Robalzotan, Ebalzotan, Sarlzotan, Piperine, Protokylol, Isoprenaline, Rhoeadine, MDMPEA, MMDPEA, MMDMPEA, MDIP, MDHOET, MDPL, GYKI-52895, Ungiminorine, NADA, Methylene blue, ECG, EGCG, EGC, Levonantradol, Cone Snail Venom, A-836,339, Abacavir, CYP-LAD, 2-Bromo-LSD, BU-LAD, DAM-57, DAL, Epicriptine, Ergometrine, Ergometrinine, Ergostine, ETH-LAD, LEA-32, Methylergometrine, MLD-41, LSP, LSH, MIPLA, PARGY-LAD, PRO-LAD, DCG-IV, DOV-102,677, MDCPM, MNTX, Amfonelic acid, J-113,397, SB-612,111, VUF-6002, DBM, Piberatine, Ilercimide, Dithranol, Divaplon, Ebastine, Flopropione, Iloperidone, Ketorolac, Melperone, NNC-38-1044, Tetralone, Cuscohydrine, Hygrine, 4-NEMD, Aceburic Acid, Amfecloral, Aprobarbital, Arfendazam, Benzobarbital, Benzylbutylbarbituate, Brallobarbital, Brophebarbital, Buthalitol, Carbubarb, Climazolam, Cyclobarbital, Cyclopentobarbital, and Acid (i.e. regular LSD).
[March 12 2020 update: Both TSC and IPS are being postponed due to the coronavirus situation. At the moment we don’t know if the other two events will go ahead. I’ll update this entry when there is a confirmation either way. May 6 2020 update: unSCruz was canceled this year as well. More so, as an organization, QRI has chosen not to attend Ephemerisle this year, whether or not it ends up being canceled. Dear readers: I’m sure we’ll have future opportunities to meet in person].
These are the 2020 events lined up for me at the moment (though more are likely to pop up):
I am booking some time in advance to meet with Qualia Computing readers, people interested in the works of the Qualia Research Institute, and potential interns and visiting scholars. Please message me if you are attending any of these events and would like to meet up.
Title – Topological Segmentation: How Dynamic Stability Can Solve the Combination Problem for Panpsychism
Abstract – The combination problem complicates panpsychist solutions to the hard problem of consciousness (Chalmers 2013). A satisfactory solution would (1) avoid strong emergence, (2) sidestep the hard problem of consciousness, (3) prevent the complications of epiphenomenalism, and (4) be compatible with the modern scientific world picture. We posit that topological approaches to the combination problem of consciousness could achieve this. We start by assuming a version of panpsychism in which quantum fields are fields of qualia, as is implied by the intrinsic nature argument for panpsychism (Strawson 2008) in conjunction with wavefunction realism (Ney 2013). We take inspiration from quantum chemistry, where the observed dynamic stability of the orbitals of complex molecules requires taking the entire system into account at once. The scientific history of models for chemical bonds starts with simple building blocks (e.g. Lewis structures), and each step involves updating the model to account for holistic behavior (e.g. resonance, molecular orbital theory, and the Hartree-Fock method). Thus the causal properties of a molecule are identified with the fixed points of dynamic stability for the entire atomic system. The formalization of chemical holism physically explains why molecular shapes that create novel orbital structures have weak downward causation effect on the world without needing to invoke strong emergence. For molecules to be “natural units” rather than just conventional units, we can introduce the idea that topological segmentation of the wavefunction is responsible for the creation of new beings. In other words, if dynamical stability entails the topological segmentation of the wavefunction, we get a story where physically-driven behavioral holism is accompanied with the ontological creation of new beings. Applying this insight to solve the combination problem for panpsychism, each moment of experience might be identified with a topologically distinct segment of the universal wavefunction. This topological approach makes phenomenal binding weakly causally emergent along with entailing the generation of new beings. The account satisfies the set of desiderata we started with: (1) no strong emergence is required because behavioral holism is implied by dynamic stability (itself only weakly emergent on the laws of physics), (2) we sidestep the hard problem via panpsychism, (3) phenomenal binding is not epiphenomenal because the topological segments have holistic causal effects (such that evolution would have a reason to select for them), and (4) we build on top of the laws of physics rather than introduce new clauses to account for what happens in the nervous system. This approach to the binding problem does not itself identify the properties responsible for the topological segmentation of the universal wavefunction that creates distinct moments of experience. But it does tell us where to look. In particular, we posit that both quantum coherence and entanglement networks may have the precise desirable properties of dynamical stability accompanied with topological segmentation. Hence experimental paradigms such as probing the CNS at femtosecond timescales to find a structural match between quantum coherence and local binding (Pearce 2014) could empirically validate our solution to the combination problem for panpsychism.
Letter I: Introduction
We are Maggie & Anders. A mostly harmless Swedish old-timer couple only now beginning to discover the advanced incompetence that is the proto-science — or “alchemy” — of consciousness research. A few centuries ago a philosopher of chemistry could have claimed with a straight face to be quite certain that a substance with negative mass had to be invoked to explain the phenomenon of combustion. Another could have been equally convinced that the chemistry of life involves a special force of nature absent from all non-living matter. A physicist of today may recognize that the study of consciousness has even less experimental foundation than alchemy did, yet be confident that at least it cannot feel like somethingto be a black hole. Since, obviously, black holes are simple objects and consciousness is a phenomenon which only emerges from “complexity” as high as that of a human brain.
Is there some ultimate substrate, basic to reality and which has properties intrinsic to itself? If so, is elementary sentience one of those properties? Or is it “turtles all the way down” in a long regress where all of reality can be modeled as patterns within patterns within patterns ending in Turing-style “bits”? Or parsimoniously never ending?
Will it turn out to be patterns all the way down, or sentience all the way up? Should people who believe themselves to perhaps be in an ancestor simulation take for granted that consciousness exists for biologically-based people in base-level reality? David Chalmers does. So at least that must be one assumption it is safe to make, isn’t it? And the one about no sentience existing in a black hole. And the one about phlogiston. And the four chemical elements.
This really is good material for silly comedy or artistic satire. To view a modest attempt by us in that direction, please feel encouraged to enjoy this youtube video we made with QRI in mind:
When ignorance is near complete, it is vital to think outside the proverbial box if progress is to be made. However, spontaneous creative speculation is more context-constrained than it feels like, and it rarely correlates all that beautifully with anything useful. Any science has to work via the baby steps of testable predictions. The integrated information theory (IIT) does just that, and has produced encouraging early results. IIT could turn out to be a good starting point for eventually mapping and modeling all of experiential phenomenology. For a perspective, IIT 3.0 may be comparable to how Einstein’s modeling of the photoelectric effect stands in relation to a full-blown theory of quantum gravity. There is a fair bit of ground to cover. We have not been able to find any group more likely than the QRI to speed up the process whereby humanity eventually manages to cover that ground. That is, if they get a whole lot of help in the form of outreach, fundraising and technological development. Early pioneers have big hurdles to overcome, but the difference they can make for the future is enormous.
For those who feel inspired, a nice start is to go through all that is on or linked via the QRI website. Indulge in Principia Qualia. If that leaves you confused on a higher level, you are in good company. With us. We are halfway senile and are not information theorists, neuroscientists or physicists. All we have is a nerdy sense of humor and work experience in areas like marketing and planetary geochemistry. One thing we think we can do is help bridge the gap between “experts” and “lay people”. Instead of “explain it like I am five”, we offer the even greater challenge of explaining it like we are Maggie & Anders. Manage that, and you will definitely be wiser afterwards!
Letter II: State-Space of Matter and State-Space of Consciousness
A core aspect of science is the mapping out of distributions, spectra, and state-spaces of the building blocks of reality. Naturally occurring states of things can be spontaneously discovered. To gain more information about them, one can experimentally alter such states to produce novel ones, and then analyze them in a systematic way.
The full state-space of matter is multidimensional and vast. Zoom in anywhere in it and there will be a number of characteristic physics phenomena appearing there. Within a model of the state-space you can follow independent directions as you move towards regions and points. As an example, you can hold steady at one particular simple chemical configuration. Diamond, say. The stable region of diamond and its emergent properties like high hardness extends certain distances in other parameter directions such as temperature and pressure. The diamond region has neighboring regions with differently structured carbon, such as graphite. Diamond and graphite make for an interesting case since the property of hardness emerges very differently in the two regions. (In the pure carbon state-space the dimensions denoting amounts of all other elements can be said to be there but set to zero). Material properties like hardness can be modeled as static phenomena. According to IIT however, consciousness cannot. It’s still an emergent property of matter though, so just stay in the matter state-space and add a time dimension to it. Then open chains and closed loops of causation emerge as a sort of fundamental level of what matter “does”. Each elementary step of causation may be regarded to produce or intrinsically be some iota of proto-experience. In feedback loops this self-amplifies into states of feeling like something. Many or perhaps most forms of matter can “do” these basic things at various regions of various combinations of parameter settings. Closed causal loops require more delicate fine-tuning in parameter space, so the state-space of nonconscious causation structure is larger than that of conscious structure. The famous “hard problem” has to do with the fact that both an experientially very weak and a very strong state can emerge from the same matter (shown to be the case so far only within brains). A bit like the huge difference in mechanical hardness of diamond and graphite both emerging from the same pure carbon substrate (a word play on “hard” to make it sticky).
By the logic of IIT it should be possible to model (in arbitrarily coarse or fine detail) the state-space of all conscious experience whose substrate is all possible physical states of pure carbon. Or at room temperature in any material. And so on. If future advanced versions of IIT turn out to be a success then we may guess there’ll be a significant overlap to allow for a certain “substrate invariance” for hardware that can support intelligence with human-recognizable consciousness. Outside of that there will be a gargantuan additional novel space to explore. It ought to contain maxima of (intrinsic) attractiveness, none of which need to reside within what a biological nervous system can host. Biological evolution has only been able to search through certain parts of the state-space of matter. One thing it has not worked with on Earth is pure carbon. Diamond tooth enamel or carbon nanotube tendons would be useful but no animal has them. What about conscious states? Has biology come close to hit upon any of the optima in those? If all of human sentience is like planet Earth, and all of Terrestrial biologically-based sentience is like the whole Solar System, that leaves an entire extrasolar galaxy out there to explore. (Boarding call: Space X Flight 42 bound for Nanedi Settlement, Mars. Sentinauts please go to the Neuralink check-in terminal).
Of course we don’t currently know how IIT is going to stand up, but thankfully it does make testable predictions. There is, therefore, a beginning of something to be hoped for with it. In a hopeful scenario IIT turns out to be like special relativity, and what QRI is reaching for is like quantum gravity. It will be a process of taking baby steps, for sure. But each step is likely to bring benefits in many ways.