The Best Ergonomic Mouse for 2021- Reviews and Buyer’s Guide

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Updated April 28th, 2021

computer mouse

The Different Types of Ergonomic Mouse

  1. Ergonomic “Horizontal” Mouse:

  2. Ergonomic “Vertical” Mouse:
    twisting of the wrist
    has been linked

  3. Trackball Mouse:

  4. Pen Mouse: Not to be confused with a stylus, a pen mouse

  5. Joystick Mouse:
    3M Optical Mouse.

The Best Ergonomic Mouse for 2021

Mouse Buttons Connection Verdict Details

R-Go Tools Break
5 Wired and Wireless Versions Best Overall Ergonomic Mouse for 2021 Check Price

Logitech MX Master 3
7 Bluetooth, Unify Receiver Top Productivity Ergonomic Mouse Check Price

J-Tech Digital V628 Vertical Mouse
4 Wired and Wireless Versions Best Overall Vertical Ergonomic Mouse Check Price

Anker Wireless Mouse
5 2.4 GHz Wireless Best Ergonomic Mouse for Laptops Check Price

Evoluent Vertical Mouse
6 Wired Best Mouse for Carpal Tunnel and Tendinitis Check Price

Mojo Silent Mouse
6 Bluetooth Best Ergonomic Bluetooth Mouse Check Price

JellyComb Mouse
6 2.4 GHz Wireless Best Ergonomic Mouse for Small Hands Check Price

Zelotes Mouse
11 Wired Best Ergonomic Gaming Mouse Check Price

Kensington Orbit
2 Wired Best Trackball Mouse Check Price

1. R-Go Tools Break– Best Overall Ergonomic Mouse for 2021

comfort and fit.

larger variant

as well for people with larger hands.



2. Logitech MX Master 3– Top Productivity Ergonomic Mouse

MX Master 2s version

that make it even more comfortable to use.



  • Some Mac users complain of Bluetooth connection issues
  • Strictly for right handed users

3. J-Tech Digital V628 Ergonomic Mouse– Best Overall Vertical Ergonomic Mouse

J-Tech vertical mouse

as the hands down

best ergonomic vertical mouse

Anker 2.4g Vertical Mouse

J-Tech Digital V628 Scroll Mouse Ergonomic Vertical Mouse Review

J-Tech Mouse


  • Very responsive Customer Support


  • Some users report quality issues upon arrival

4. Anker 2.4g Mouse– Best Ergonomic Mouse for Laptops

J-Tech Digital V628

which comes in 4 times as much.


  • Compact and slim for laptops or travel
  • Physical DPI switching buttons
  • Budget friendly, at less than $20


  • Mouse surface a little slippery for me

5. Evoluent Vertical Mouse Regular Size– Best Mouse for Carpal Tunnel and Tendinitis

Evoluent is the

original creator of the vertical mouse

in a completely, natural, untwisted position

physical therapists

at the health clinic in UC Berkeley.

best vertical mice for wrist pain

out there.



  • Expensive relative to other mouse
  • Long adjustment period for many people

6. MOJO Silent Vertical Mouse– Best Ergonomic Bluetooth Mouse

will NOT work

In terms of function and finish, the

Mojo vertical mouse



7. Jelly Comb Wireless Vertical– Best Ergonomic Mouse for Small Hands


Another noteworthy feature of the

Jelly Comb vertical mouse

the Jelly Comb is your best bet


  • Lifetime replacement gaurantee


  • Single AA battery required not included.

8. ZLOTES Vertical Gaming Mouse– Best Ergonomic Gaming Mouse

Zelotes C18 Gaming Mouse

gaming mouse


  • Rare vertical design in a gaming mouse
  • 5 adjustable DPI settings, up to 10000 DPI
  • Physical DPI switch
  • 11 programmable buttons, including useful rocker
  • Mood setting LED lighting


  • Only wired version available
  • Software download required to modify buttons

9. Kensington Orbit– Best Trackball Mouse


large scroll ring

Logitech Trackman

, with the Orbit instead for 2021.

Trackball vs Regular Mouse

for more information.



  • Comfortable rubber padded wrist pad


  • Not as precise as a regular mouse
  • Wired connection creates some clutter.


Is an Ergonomic Mouse Necessary?

Picking the Best Ergonomic Mouse for YOU

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